Gogusev J, Duchambon P, Zhang P, Dousseau M, Giovannini M,
Sarfati E, Drueke TB
Expression of Bcl-2 oncoprotein in parathyroid tissue of
patients with primary and secondary hyperparathyroidism
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:961 1995
The protein encoded by the bcl-2 oncogene may block apoptosis. This protein
was strongly expressed (as measured by staining) in chief cells of normal
parathyroid cells. Moderate to modest staining was seen
in 6/11 secondary and 2/8 primary hyperparathyroid tissues. Nodular areas
were mostly bcl-2
negative. The authors conclude that reduced expression of the bcl-2
oncoprotein in
parathyroid tissue from patients with primary or secondary
hyperparathyroidism could indicate a
high degree of apoptosis in parathyroid hyperplasia.
Comment: These are surprising results the significance of which is
unclear.
(Delmez)
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Am Soc Nephrol
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