Heering P, Morgera S, Heering P, Schmitz FJ, Heintzen M,
Willers R, Grabensee B
Cytokine removal and cardiovascular hemodynamics in
patiens with ARF and treatment with CVVH Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:601 1995
This is a prospective study of cytokine removal by CRRT. CVVH
was used in 33 patients (18 with septis and 15 with primarily cardiovascular
problems) with
ARF. Multiple cytokines, including TNFà, IL-6 and IL-1 and their
receptors were measured in the blood and ultrafiltrate at different
time points after initiation. No significant changes in blood
levels of cytokines were seen, although TNFà was detected in UF.
Hemodynamic improvement was seen in 24 hours, but could not be
ascribed to cytokine removal. This study is similar to the ASN95 abstract by
Manns et al. which also found hemodynamic improvement in sepsis with
CRRT, but the data presented here do not
demonstrate that this improvement is associated with cytokine removal.
(Mehta)
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