Hommel E, Jensen B, Parving H-H
Long-term effect of captopril on kidney function in
normotensive insulin-dependent diabetic patients with diabetic
nephropathy Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:450 1995
32 normotensive patients with IDDM and nephropathy were randomized to Rx with
captopril (12.5-125 mg/d) or to a control group and followed for 8 years. BP
was constant in the treated group (128/78 - 129/77 mm Hg) but increased in
controls (127/79 - 137/84). Fractional albumin clearance was unchanged in
the captopril group but increased in controls. The GFR decline was similar
in the two
groups. Captopril has a long-lasting beneficial effect on BP and
proteinuria; however loss of GFR is minimal providing normotension is
sustained.
(Leehey)
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