Honkanen E, Toppo A-M, Tornroth T, Gronhagen-Riska C
Urinary transforming growth factor beta-1 and
progression of glomerular diseases
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:922 1995
TGF-beta regulates rate of accumulation of extracellular matrix and
development of glomerular sclerosis. Urinary TGF-b1 was measured using
double antibody EIA in patients with membranous nephropathy, diabetic
nephropathy, and controls. Values were strikingly higher in diabetic
nephropathy (422 pg/mg creat) and membranous nephropathy (158) than in
controls (10). Excretion rate was higher in patients with sclerotic
glomerular lesions and with declining GFR.
(Leehey)
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Am Soc Nephrol
CRF by problem area :
Progression