Humes HD, Cieslinski DA, Funke AJ
Cell therapy for erythropoeitin-deficient anemias
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:535 1995
This novel study looked at the use of cell therapy - a hepatoma cell line
was
found to produce EPO as oxygen tension was decreased. A delivery device was
then developed, a hollow fiber bioreactor onto which the hepatoma cells
would
be seeded. The device could then be injected intravascularly to provide a
mechanism for chronic, ?regulated EPO delivery.
Comment: Fascinating, but there are a number of obvious obstacles to
overcome, such as is there a risk to having hepatoma cells present in a
major
blood vessel.
(Fishbane)
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Am Soc Nephrol
CRF by problem area :
Anemia/Erythropoietin/Iron