Kimmel PL, Mishkin G, Umana W
Captopril increases renal survival in patients with HIV
nephropathy
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:423 1995
This paper has now been published in August 1996 AJKD 28:202.
Renal survival was measured from time of biopsy in cases of HIV associated
nephropathy (HIVAN) and compared in 9 patients taking captopril and 9 not
taking captopril. This was not a randomized trial, but was sort of
prospective. The captopril treated patients had a longer (83 days vs. 30
days) renal survival (defined as time to dialysis). Creatinines at baseline
were similar, although proteinuria was less initially in the captopril group
(5 g/day) vs controls (10 g/day). It was not clear if this was due to
captopril tx at time of initial assessment or to a selection bias.
(Daugirdas)
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Am Soc Nephrol
Proteinuria/Hematuria :
HIV-associated nephropathy