Kloppenburg WD, Wolthers BG, Tepper T, Stegeman CA, de Jong
PE, Huisman RM
Fluctuations of urea generation rate following protein
intake in hemodialysis patients measured using [13-C]-urea
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:581 1995
In urea kinetic modeling equations, it is assumed that the rate
of urea generation is constant over time. The temporal relation
between protein ingestion and urea generation has not been well
studied. In 4 fasting HD patients, urea generation was estimated
from the disappearance curve of the stable 13-C-urea isotope
after IV injection. Patients consumed 44 g of protein as a meal
4 hours after isotope injection. A marked dilution of the
labelled urea could be seen, beginning within 10 minutes of
protein ingestion. The high protein meal resulted in a 1.5-3.7
fold transient increase in the rate of urea generation.
Comment: Ingestion of a high protein meal during
or after dialysis may have important effects on urea modeling
calculations.
(Daugirdas)
To go back use the BACK button on your browser.
Otherwise click on the desired link to this article below:
Am Soc Nephrol
Basic hemodialysis :
Physiology