Langenfeld MRW, Rupprecht G, Schobel HP, Schmieder RE
Endogenous erythropoietin correlates with arterial blood
pressure in essential hypertension
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:644 1995
In an interesting descriptive study these authors examined echo
based cardiac output, renal PAH and inulin clearance, and 24
hour ambulatory blood pressure and their association with
endogenous EPO in 42 people with essential hypertension. A
statistically positive correlation was detected between EPO
levels and mean systolic (r=0.50) and diastolic blood pressure
(r=0.50), peripheral vascular resistance by echo (r=0.4), a
reduction in renal plasma flow (r=-0.32), and a rise in renal
vascular resistance (r=0.41). No correlation was noted with Hct
concentration. While the strength of the associations in this
study are rather low and no cause-effect relationship between
EPO and the development of essential hypertension has been
established, these data do raise another possible predictive
tool for screening.
(Narsipur)
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Am Soc Nephrol
H: Pathophysiology :
Hormonal aberrations
CRF by problem area :
Anemia/Erythropoietin/Iron