Lockwood CM, Stewart S, Thiru S, Isaacs JD, Hale G, Elliott
J, Waldmann H
Humanized monoclonal antibody therapy for Wegener's
granulomatosis
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:925 1995
13 patients with WG (ANCA + multisystem disease) who could not tolerate or
did not respond to conventional immunosuppresive therapy were treated with
humanised monoclonal antibodies. Treatment-free remission was obtained in
12
patients. Renal function improved in 5 patients studied; no benefit was
noted
in 3 patients already dialysis-dependent. Pulmonary lesions resolved in 4/4
patients. Although a small series, these data suggest a promising new
approach for the treatment of WG.
(Leehey)
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Am Soc Nephrol
Proteinuria/Hematuria :
Vasculitis (Wegener's PAN, etc.)