Mitsuhashi T, Li Y-M, Fishbane S, Vlassara H
Depletion of advanced glycated end-products (AGEs) in uremic
serum and dialysis fluid by an AGE-binding lysozyme-matrix
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:498 1995
Serum from diabetic patients with ESRD contains high levels of AGE which
could
contribute to vascular disease. An AGE-binding column was constructed with
lysozyme-linked Sepharose beads. This matrix could capture in vivo formed
crosslinking, AGE-containing species in diabetic sera. This may provide a
novel approach for removing these substances from diabetic patients with
ESRD.
(Leehey)
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Am Soc Nephrol
CRF by problem area :
CRF and diabetes
Other extracorporeal therapies :
Plasmapheresis