Morishita T, Saitoh Y, Tsukamoto Y, Tominaga Y
Marked expression of c-fos/jun proteins in hyperplastic
parathyroid glands
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:967 1995
The involvement of the oncoproteins c-jun and c-fos was studied in 20
parathyroid glands with
nodular hyperplasia removed from 5 HD patients undergoing PTX for severe
hyperparathyroidism. Thirteen glands showed a strong positive staining for
both oncogenes. The
author conclude that the induction of the oncogenes must play a role in the
parathyroid cells found in
severe secondary hyperparathyroidism.
Comment: This is an important issue, but the data would be
strengthened by inclusion of normal parathyroid glands for comparison,
and perhaps data on glands from patients with primary hyperparathyroidism.
(Delmez)
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Am Soc Nephrol
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