Nielsen FS, Ali S, Rossing P, Bang LE, Svendsen TL, Gall M-A,
Smidt UM, Kastrup J, Parving H-H
Left ventricular hypertrophy and systolic dysfunction in non
-insulin dependent diabetic patients with and without diabetic
nephropathy
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:449 1995
51 NIDDM with nephropathy and 53 NIDDM with normoalbuminuria and 22
non-diabetic control subjects were studied with echo for left ventricular
mass
index and shortening fraction. Their 24-hour blood pressure and plasma
volume
were measured. Compared to controls, left ventricular mass index was
significantly increased in both NIDDM patient groups. Shortening fraction
was impaired in a third of both NIDDM patient groups compared to
the control group. Multiple regression analysis indicated that the strongest
predictors of left ventricular mass index were impaired-nocturnal decline in
blood pressure and expanded plasma volume. The study concluded that
normotensive and hypertensive NIDDM patients with and without diabetic
nephropathy suffer from left ventricular hypertrophy and dysfunction -
independent risk factors for cardiac events.
(Khanna)
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Am Soc Nephrol
H: Exam and lab tests :
Tests for LVH
H: Special problems :
Obesity, Insulin Resistance