Parving H-H, Tarnow L, Nielsen FS, Rossing P, Mandrup-Poulsen
T, Nerup J
Cyclosporine nephrotoxicity in insulin-dependent diabetic
patients: an eight year follow up
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:454 1995
Cyclosporine has been used to treat patients with early insulin
dependent diabetes mellitus in an attempt to abort the disease.
In this randomized study, 21 patients received cyclosporine for
12 months and 19 patients received placebo. Over an 8-year
follow-up 4/18 cyclosporine-treated patients developed
persistently elevated urinary albumin excretion, whereas UAE
remained normal in the placebo-treated patients, with the
exception of 1 patient with biopsy-proven IgA nephropathy. A
kidney biopsy in 5 of the cyclosporine-treated patients was
consistent with cyclosporine-induced nephropathy. Furthermore,
the GFR declined in the cyclosporine-treated group, whereas it
rose in the placebo-treated group. The results suggest that
cyclosporine treatment of young diabetic patients may not be
benign and may accelerate the progression of renal disease.
(Daugirdas)
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Am Soc Nephrol
Proteinuria/Hematuria :
Diabetes
ARF etiology :
Cyclosporine, ARF in transplant patients