Pedrini MT, Lau J, Levey AS, Chalmers TC, Wang PH
Effect of dietary protein restriction on the progression of
non-diabetic renal disease: meta-analysis
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:399 1995
The question of whether
protein restricted diets slow the progression of renal disease in humans
remains controversial.
A meta-analysis of 6 trials with a total of 890 patients published in 1992
(Brit Med J 1992; 304:
216) showed a significant reduction in renal failure or death in patients on
protein restricted
diets. This new meta-analysis by Pedrini et al. includes the
MDRD results. Five trials with a total of 1419 patients used a randomized
control design, had mean
follow up longer than one year, and reported the number of patients who
developed renal failure
or died. The overall relative risk for the development of renal failure or
death in patients on
protein restricted diets in these five trials was 0.67 (P=.007). The range
of protein intake in
subjects on protein restriction in these five trials was 0.4-0.8 g/kg/day
compared to 0.8-1.3
g/kg/day in controls.
Comment: This meta-analysis indicates that dietary protein
restriction reduces the risk
of ESRD and death in patients with established renal disease by about 30%.
(Vardaman M. Buckalew)
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Am Soc Nephrol
CRF by problem area :
Progression