Pontremoli R, Bezante GP, Sofia A, Tirotta A, Ravera M, Nicolella C, Viazzi F, Bobola N, et al.
Deletion polymorphism of the ACE gene is a risk factor for target organ damage in essential hypertension
Am Soc Nephrol
J Am Soc Nephrol (abstract) (Nov) 6:647 1995

This study examined the links between ACE genotype, microalbuminuria, retinopathy, and LVH in 108 patients with essential hypertension. The distribution of the DD, ID, and II genotypes was 31, 49, and 20% respectively. The DD and ID genotypes were associated with microalbuminuria and retinopathy, as well as with LVH, with odds ratios in the range of 5-8. Patients with the D allele also had larger hearts compared with II patients. These differences were found despite similar distributions of age, known duration of disease, body mass index and blood pressure, and other common risk factors. (Daugirdas)

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Am Soc Nephrol
H: Pathophysiology : Genetics


The genetics aspects in hypertension is becomes interesting. I am starting a trial between Venezuelan hypertensive Blacks and no blacks. I will search their ACE genotypes, blood pressure response to quinapril and Know if our blacks patients are the same that African American in US.
Danilo Perez-Monagas (dperezmo@sa.onmes.net)
Barquisimeto, Lara Venezuela-Tuesday, July 23, 1996 at 23:36:25 (CDT)

The genetis aspect of the hypertension is quite interesting.I wrote a protocol to do it in Farriar, Yaracuy State of Venezuela.In this small rural town we find black people like USA. This black people have african ancestor. I infer that the gene are the same that the african americans, but the enviroment is different. We search their ACE genotype and we want to see the BP response to treatment with quinapril (Accupril) based in their genetic. We will compare with hypertensive patient not black.
Danilo Perez-Monagas,MD (dperezmo@sa.omnes.net)
Barquisimeto, Lara Venezuela-Wednesday, July 31, 1996 at 23:15:54 (CDT)