Rahman M, Austen A, Brown R, Phinney M, Carey J, Kalayjian R,
Weigel K, Smith MC
Prednisone ameliorates the progression on HIV-associated
nephropathy
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:430 1995
This is a follow-up to a previous recently published report by
this group in JASN in 1994 suggesting that prednisone may be of
benefit to patients with HIV-associated nephropathy. 19 patients
with clinical or biopsy-proven HIV-associated nephropathy were
treated with prednisone at a dose of 60 mg per day for 2-6 weeks
and followed for a median of 56 weeks. 17 patients responded
with a fall in serum creatinine from an average of 8 mg/dL to 3
mg/dL, and a fall in urinary protein excretion from 9 to 3 g/24
hours. Four patients were able to discontinue dialysis. Five
patients relapsed when prednisone was discontinued but improved
with a second course of steroid treatment. The authors conclude
that prednisone therapy delays or prevents the development of
ESRD in HIV nephropathy, although 40% ultimately progressed to
end stage renal failure.
(Daugirdas)
To go back use the BACK button on your browser.
Otherwise click on the desired link to this article below:
Am Soc Nephrol
Proteinuria/Hematuria :
HIV-associated nephropathy