Rampino T, Libetta C, Dal Canton A, DeSimone W, Memoli B
In vivo effect of intravenous 1,25-dihydroxyvitamin D3 on
interleukin-2 production in hemodialysis patients
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:969 1995
The investigators studied the in vivo and in vitro effects of calcitriol on
the lymphocytic
production of IL-2 and IL-2 receptors in patients on hemodialysis.
Incubating lymphocytes with
calcitriol decreased the production of both. Three months of Rx with IV 1 ug
after each dialysis
calcitriol also decreased the production of both. The in vivo experiments
are contrary to that
previously described in patients receiving oral calcitriol. The authors
ascribe the difference to
the higher levels of calcitriol achieved with the intravenous route.
(Delmez)
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Am Soc Nephrol
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