Rossing P, Tarnow L, Nielsen FS, Hansen BV, Brenner BM,
Parving H-H
Low birth weight a risk factor for development of diabetic
nephropathy?
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:454 1995
In a case-control study, the study investigated 184 IDDM patients with
diabetic
nephropathy (mean duration of diabetes 27 years) and 182 normoalbuminuric
IDDM patients (mean duration of diabetes 26 years) including their birth
weight from
midwives' original registrations. In women below the 10th percentile birth
weight,
75% had nephropathy compared to 35% in women above the 90th percentile. The
prevalences of nephropathy in men in both groups were similar at about 50 %.
Adult height significantly correlated with birth weight. Men with diabetic
nephropathy were significantly shorter than men with normoalbuminuria. The
study supports the hypothesis that genetic predisposition or factors
operating in utero or early childhood or both, contribute to the development
of diabetic nephropathy.
(Khanna)
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Am Soc Nephrol
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