Sansonno D, Gesualdo L, Manno C, Schena FP, Dammacco F
Localization of HCV in renal tissue of HCV-infected patients
with cryoglobulinemic mesangiocapillary glomerulonephritis: an
immuno-histochemical study
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:431 1995
In this study, the authors observed positive immuno-histochemical
staining with murine monoclonal antibodies against c22-3 and c100-3 proteins
of HCV along the glomerular capillary walls, peri-tubular small renal vessels
and within the intra-tubular eosinophilic material in renal tissue specimens
of patients with HCV associated cryoglobulinemic MCGN. No such staining was
observed in patients with MCGN without anti-HCV or HCV RNA. This study
demonstrates immuno-morphological evidence of HCV related antigens within
the kidney of patients affected with cryoglobulinemic MCGN.
(Bhamidipati/Pereira)
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Am Soc Nephrol
Proteinuria/Hematuria :
Hepatitis-associated nephropathy