Sharmir E, Peng S, Fouque D, Kopple JD
Effect of insulin-like growth factor 1 on nitrogen
balance in malnourished CAPD patients
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:587 1995
This abstract describes continuing work from Kopple et al on the
use of recombinant IGF-1 in malnourished CAPD patients. It describes 6
patients who spent 35 days in a CRC. This comprised 15 days for
baseline observations and 20 days of rhIGF-1 therapy at 50 or 100 #g/kg
twice daily. The authors find dramatic drops in BUN and dialysate N
losses, with a markedly positive N balance on rhIGF treatment. Serum
albumin and anthropometric indices did not change. The authors
conclude that the anabolic effect is significant and mainly involves
somatic protein.
While these observations are interesting, there is clearly a need
to prove the viability and safety of this therapy over longer periods of
time in dialysis patients.
(Blake)
To go back use the BACK button on your browser.
Otherwise click on the desired link to this article below:
Am Soc Nephrol
CRF by organ system :
Nutrition