Sharma K, McGowen T, Ziyadeh FN, Kurnik B, Kurnik P, Weisberg
L
Renal production of TGF-beta is increased in diabetic
patients
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:455 1995
Increased renal production of TGF-b has been demonstrated in diabetic
animals
and in cultured renal cells incubated in high glucose media. Renal vein and
aortic plasma samples were obtained from diabetic and non-diabetic patients
with
normal renal function without microalbuminuria undergoing cardiac cath.
Total TGF-b1 was measured using sandwich ELISA. Diabetic patients had net
renal
production of TGF-b in contrast to nondiabetics who had net consumption.
(Leehey)
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Am Soc Nephrol
Proteinuria/Hematuria :
Diabetes