Slatopolsky E, Finch J, Denda M, Ritter C, Zhong M, Dusso A,
MacDonald P, Brown A
Phosphate restriction prevents parathyroid cell growth in
uremic rats and high phosphate directly stimulated PTH
secretion in tissue culture
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:971 1995
The role of hyperphosphatemia in increasing PTH secretion is
becoming established. In this study cells cultured from normal
rat parathyroid glands showed a marked increase in PTH secretion
when the glands were exposed to a high phosphorus concentration.
This was a post-transcriptional effect as there was no alteration
in PTH mRNA. When normal and uremic rats were fed low and high
phosphorus diets, the parathyroid glands increased markedly in
weight in the uremic rats fed the high phosphorus diet. Also,
the high phosphorus diet caused a marked increase in serum PTH
levels.
Comment: These data are in agreement with
previous work done in dogs by this same group and show that high
phosphorus has a direct stimulatory effect on PTH secretion, the
mechanism of which remains undefined, but which, from this study,
appears to be post-transcriptional in nature.
(Daugirdas)
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Am Soc Nephrol
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