Svarstad E, Gerdts E, Omvik P, Iversen BM, Ofstad J
Captopril and doxasozin induce similar change in
renal hemodynamics in hypertensive patients with diabetes
mellitus
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:650 1995
The role of alpha blockers on renal functions in IDDM is unknown. The
effects of captopril (100 mg/d) and doxazosin (6.1 mg/d) on GFR and renal
hemodynamics were compared in hypertensive patients with IDDM. Filtration
fraction and renal vascular resistance were decreased by both drugs; GFR
(iothalamate-I125) and ERPF (hippuran-I131) were not affected by either
drug.
The similar changes in renal hemodynamics suggests that these drugs may have
similar renoprotective effects.
(Leehey)
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Am Soc Nephrol
H: Drug therapy :
Alpha and alpha/beta blockers
H: Drug therapy :
ACE inhibitors