Tsukamoto Y, Kobayashi N, Nomura Y, Heisi M
Vitamin D receptor gene polymorphism and severity of
secondary hyperparathyroidism
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:972 1995
The influence of VDR receptor polymorphism (bb,Bb,BB) on serum PTH levels was
examined.
354 HD patients treated with CaCO3 and calcitriol if PTH greater than 3x the
upper limits of normal were
studied. The occurrence of allelic variation was equal between 105 healthy
subjects and the study
population. There was no association between allelic type and PTH>10 ng/ml
or <10 ng/ml
although there was a borderline association with Bb and PTH greater than 10
ng/ml in those on
dialysis less than 5 years (P=0.054). It was concluded that non-genetic
factors are more important than VDR
receptor subtype in the genesis of hyperparathyroidism.
Comment: A linear regression analysis encompassing Ca, P etc. would
add to the abstract.
(Delmez)
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Am Soc Nephrol
CRF by problem area :
Bone disease/aluminum