Vats A, Basgen J, Steffes M, Mauer M
Glomerular number in focal segmental glomerulosclerosis
and minimal change nephrotic syndrome
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:930 1995
This study examined the hypothesis that progression of minimal
change nephropathy (MCN) to focal glomerulosclerosis (FSGS), or
that the partition between these two pathologic findings may be
related to the number of glomeruli. Kidney biopsies from 32
patients were analyzed. 10 had MCN for more than 15 years with
no progression. 11 had steroid-resistant FSGS. The remainder
were age-matched biopsies from renal donors. The glomerular
volume was estimated from the kidney volume as determined by IVP
or renal ultrasound. The results showed that the estimated
number of glomeruli was similar in patients with MCN and
controls, but was substantially reduced in patients who had FSGS.
The result lead to a hypothesis that patients with a low number
of glomeruli may be more susceptible to develop FSGS.
(Daugirdas)
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Am Soc Nephrol
Proteinuria/Hematuria :
Focal, collapsing, fibrillary GN
Proteinuria/Hematuria :
Minimal change disease