Benkataseshan VS, Aron N, D'Agati VD
Renal lesions in drug induced lupus syndromes
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:931 1995
Renal involvement in drug-induced lupus (DIL) is rare. 18 patients treated
with hydralazine,
procainamide, phenytoin, propylthiouracil, or other drugs were studied. Of
16 biopsies, 5
showed proliferative GN (2/5 anti-DNA +), 6 showed necrotizing GN (4/6 ANCA
+); other lesions were mesangial GN, membranous GN, minimal change, and
renal
vasculitis. In conclusion, both immune complex and pauci-immune GN can
occur
in DIL. Therapy includes drug discontinuation plus immunosuppressives.
(Leehey)
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Am Soc Nephrol
Proteinuria/Hematuria :
Lupus nephritis
Proteinuria/Hematuria :
NSAIDs and other drug-induced