Wang EJ, Shultz PJ, Tolins JP
Cyclosporine A-induced salt sensitive hypertension: role of
nitric oxide
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:673 1995
Cyclosporine causes a sodium-sensitive hypertension in the majority of
patients
given the drug. Rats with impaired nitric oxide synthesis also develop
sodium-sensitivity of blood pressure. These investigators sought to determine
whether there was a link between these phenomena. Rats were given
cyclosporine
for two weeks which did not affect blood pressure. During a third week of
cyclosporine administration rats also fed a high salt diet became
hypertensive,
associated with a decrease in serum and urine nitric oxide metabolites. They
conclude that cyclosporine impairs nitric oxide synthesis, thus causing
sodium-dependent hypertension.
(Paller)
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Am Soc Nephrol
H: Special problems :
Renal transplant patients