Worrall J, MacDougall IC, Raine AEG, Dawnay A
Effect of acutely raising the serum albumin on peritoneal
transport and ultrafiltration in CAPD patients
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:568 1995
To determine the effect of serum albumin on peritoneal clearances and
ultrafiltration, standard 4h
PETs were performed in 5 hypoalbuminemic
patients (mean serum albumin 15 g/L by RIA) and then repeated the next day
after an IV infusion of
albumin sufficient to raise serum albumin to 24 g/L.
The day after albumin infusion, overall creatinine clearance was increased by
about 15%. This was
due both to an increase in the 4h D/P creatinine, as well as to an increase
in net ultrafiltration.
The increase in clearance might have been due to rapid volume expansion
resulting in an increase in
the effective peritoneal surface area.
On the other hand, it is known that patients with high peritoneal transport
efficiency tend to have
low serum albumin levels, suggesting that high transport leads to low serum
albumin levels, and not
the reverse.
(Verger)
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Am Soc Nephrol
Basic peritoneal dialysis :
Physiology