Yoh K, Kobayashi M, Yamaguchi N, Hirayama K, Ishizu T, et al.
Superantigen-related glomerulonephritis and vasculitis due to
MRSA infection
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:436 1995
Patients with MRSA may develop glomerulonephritis possibly due to
enterotoxins (SEs). SEs stimulate resting T cells to proliferate causing
cytokine release. 26 patients with RPGN and nephrotic syndrome following
MRSA infection were studied. High levels of circulating immune complexes
and
cytokines (IL-1,2 and 6 and TNF) were noted. Renal biopsy revealed
proliferative GN with crescents with Ig and C3 deposition. All patients
were
treated with antibiotics (usually vancomycin); 15 recovered, 8 died, and 3
required maintenance dialysis. SEs may cause glomerulonephritis/vasculitis
in MRSA-infected patients.
(Leehey)
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Am Soc Nephrol
ARF etiology :
Acute glomerulonephritis/RPGN
Proteinuria/Hematuria :
Other systemic infections