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HDCN News Archive -- Clinical Pharmacology
Jul02	Fresenius opens specialty pharmacy for renal patients in Nashville.
Jul02	NEJM: Phospholipase A2 receptor is a target antigen in 70% of patients with idiopathic membranous nephropathy.
Jul02	Rebound hyperacidity, reflux symptoms in normals after stopping proton pump inhibitors
Jul02	Enalapril or losartan markedly slow progression of eye damage in type 1 diabetics.
Jul01	FDA advisory panel recommends banning Vicodin and Percocet and limiting maximum acetaminophen doses
Jun30	Common gene polymorphism affecting calcium excretion (claudin 14) linked to both kidney stones and osteoporosis.
Jun26	Mechanism of BPA (bisphenol A) related infertility defined in mice.
Jun20	New prostate cancer drug ipilimumab shows dramatic results in 2 patients.
Jun13	FDA issues alert on increased death risk in liver transplant patients taking Rapamune.
Jun13	Sevelamer carbonate (Renvela) approved for sale in the European Union
Jun10	Ferric citrate found to bind phosphate in phase II study with no marked adverse effects.
Jun05	Aldosterone levels found to be increased in chubby teenage boys.
Jun05	Telaprevir substantially increases hepatitis C cure rates (NEJM)
Jun04	Halofuginone, Th17 cells, and autoimmunity.
Jun03	FDA reports on serious liver failure risk in patients taking propylthiouracil.
May29	FDA: Serious fungal infections associated with TNF-alpha blockers.
May29	Risks of aspirin outweight benefits for primary prevention of stroke, MI in those with normal kidney function.
May26	FDA approves Samsca (tolvaptan) to treat hyponatremia.
May25	Search all abstracts from the World Congress of Nephrology 2009
May22	New anti-inflammatory drug candidate works by releasing hydrogen sulfide gas.
May22	Drinking from polycarbonate bottles for a week increases urinary bisphenol levels.
May19	NF-kappaB inhibitor might be ideal drug to combat osteoporosis and periodontitis.
May18	Edible vaccine against p24 protein of HIV elicits an antibody response in mice.
May15	Interventional study in mice links cytomegalovirus infection to high blood pressure.
May15	Metformin shown to act directly via CBP glucose-regulating protein in the liver.
May14	Monotherapy with DARA, an endothelin and angiotensin I receptor antagonist, lowers BP a lot.
May11	UMOD gene, associated with Tamm-Horsfall protein production, linked to kidney disease.
May11	Cyclophilin may play a key role in arterial damage associated with atherosclerosis.
May08	FDA approves generic version of mycophenolate mofetil
May07	Calcimimetics inhibits late-stage cyst growth in an animal model of ADPKD.
May05	Fresenius launches national retail pharmacy for dialysis patients.
May01	Survey company releases report on usage trends for vitamin D, phosphate binders, and calcimimetics.
Apr30	Januvia (sitagliptin) pancreatitis risk suggests potential drug class effect on the pancreas for GLP-1 enhancers.
Apr27	Potential importance of vitamin D receptor, commensal bacteria, and olmesartan in autoimmune disease.
Apr27	Biotech companies, including Baxter, scramble to respond to flu epidemic with vaccines.
Apr26	Prostaglandin 2-alpha may be new target for control of blood pressure and atherosclerosis.
Apr23	Bacteriophage used to successfully treat chronic Pseudomas ear infection
Apr22	Alzheimer beta-amyloid can be degraded, and some drugs can increase breakdown rate 7-fold.
Apr18	Ultrashort-acting prednisolone derivatives (antedrugs) stop inflammation and then are metabolized to avoid side effects.
Apr17	New discoveries on how collagen activates platelets may lead to new treatments to prevent clotting.
Apr16	Endothelin A receptor antagonist darusentan shows promising results in resistant hypertension.
Apr16	Provenge prostate cancer vaccine significantly prolongs survival.
Apr12	CXCL5, secreted by white adipose tissue, may be the link between obesity and inflammation and insulin resistance.
Apr11	One thousand 2007-2009 audiofiles and slide/audio talks added to HDCN's 20 topic-related channels.
A06	Impax, a generic drug manufacturer, challenged by Genzyme with Renvela patent.
M30	Variants of nisin, an FDA-approved antibiotic used in food preservation, show effectiveness against MRSA.
M30	FDA approves mTOR inhibitor everolimus for treatment of advanced kidney cancer.
M29	Link to slide/audio and audio symposia on HDCN
M25	Thymoquinone protects pancreatic beta cells from oxidative effects of protease inhibitors; a renoprotective role as well, maybe?
M22	Protein in yellow peas lowers BP by 20% in animal model of PKD.
M20	FDA panel gives nod to alternative to warfarin
M18	Another statin (Crestor, rosuvastatin) fails to show a benefit (rumor has it) in dialysis patients.
M17	Endothelial lipase linked to levels of good cholesterol
M10	Bacteriophage-derived enzyme Cpl-1 better than amoxicillin in treating pneumococcal pneumonia.
M09	Cranberry juice proanthocyanidins, and not low pH, impair E. Coli attachment to urinary bladder endothelium
M04	FDA December, 2008 drug labeling changes (including Sensipar, CellCept, Actos)
M04	Pharma consultancy of medical school faculty members in the news.
M03	AMAG hopeful that the FDA will approve its injectable iron supplement.
F27	FDA warns of tardive dyskinesia risk with Reglan (metoclopramide)
F26	Clavulanate plus meropenem found to be surprisingy effective in vitro against multidrug-resistant TB
F18	NEJM: Genetic testing helps predict warfarin dose.
F18	Study suggests that warfarin dose needs to be lower in patients with CKD.
F16	FDA approves Uloric (febuxostat) for treatment of gout.
F12	FDA and consortium release first data on genetic associations with serious drug adverse events.
F06	FDA approves antithrombin derived from the milk of genetically-modified goats.
F05	Sensory nerves in fat cells help regulate lipolysis, according to animal study.
F02	Leprosy drug clofazimine holds promise as an immunomodulatory agent.
J31	FDA advisory panel recommends that Darvon (propoxyphene) be pulled from the marked due to suicide risk, low efficacy.
J30	Epoxide hydrolase inhibitor reduces heart failure in animal model
J28	Genzyme shares climb after Amgen abandons development of phosphate drug.
J17	Kidney injury biomarker panel now commercially available for animal testing of new drugs
J16	Mutations in gene regulating melatonin-mediated insulin secretion increases type 2 diabetes risk
J15	New family of antibiotics isolated from hydras and leeches.
J15	HipA, a protein kinase, involved in bacterial dormancy, allowing survival during antibiotic therapy.
J10	FDA expert panel recommends approval of drug (antithrombin alfa) extracted from the milk of genetically-engineered goats.
J09	New anti-anginal drug acts by working on sodium channels.
J09	Human insulin produced by genetically modified safflower plants ready for testing.
J08	Quest Diagnostics acknowledges errors (mostly overestimation) in vitamin D tests.
D18	FDA raises the bar for new diabetes drugs
N19	Did you know that your prescribing history is for sale? Fed appeals court supports NH law banning the practice.
N19	FDA advisory panel greenlights anti-MRSA antibiotic telavancin, but not approved by the FDA yet.
N18	New microRNA compound protects mice against heart failure.
N18	Five days of cipro cause pervasive and persistent changes in gut microflora abundance.
N14	Renal Week: Relative vitamin K2 deficiency linked to vascular calcification in ESRD
N09	Rosuvastatin given to patients with normal cholesterol levels but high CRPs markedly lowers CV risk.
N06	Ghrelin-like drug increases muscle mass by 20% in the elderly.
N04	Strange, complex pharmacokinetics of methotrexate in RBCs have implications for clinical treatment.
O29	Animal studies suggest potential benefits of drug holiday for patients taking sulfonylureas.
O28	Topical treament for HSV cold sores achieves same results as oral systemic therapy.
O28	Plavix (clopidogrel) may be inactivated by some calcium channel blockers.
O27	Risks of irregular heartbeat and atrial fibrillation increased with fosamax and other bisphosphonates.
O27	Pentoxifylline lowers proteinuria alone or in addition to an ACE inhibitor.
O23	Hydrogen sulfide may be a key regulator of blood pressure.
O23	European watchdog agency suggests not using diet drug rimonabant due to depression side effects.
O17	FDA creates drug safety information webpages for patients and health professionals.
O14	Resveratrol found in dark chocolate and cocoa.
O14	Alpha-1-antitrypsin therapy expands beta-cell populations in the pancreas of mice with a model of type 1 diabetes.
O13	A series of abstracts presented at CRF meeting suggesting that triple anti-platelet therapy (adding cilostatzol) improved outcomes.
O07	Study illustrates importance of inflammatory macrophages in obesity; insulin resistance reversed by killing these cells.
O07	One mechanism whereby ingestion of fatty foods (but not carbs or protein) can suppress hunger identified : OEA.
O06	One-dollar-a-month polypill containing ASA, thiazide, ACEI, and statin to undergo clinical testing.
O03	On Nov 3, U.S. Supreme Court to hear key product liability court regarding use of FDA-recommended drug labels.
S26	Aptly named horny goat weed found to be a source of specific phosphodiesterase inhibitors.
S25	Diabetic gastroparesis in mice reversed by restoring defective hemo oxygenase production.
S22	Darapladib slows atherosclerosis in a pig model.
S18	Are statins ineffective for protection against cardiovascular risks in women?
S16	How should one properly dispose of unused drugs? No one seems to know.
S16	Chamomile tea cuts diabetes complications (in rats)
S16	Conbining thiazides with potassium-sparing diuretics markedly lowers cardiovascular mortality.
S15	Carvedilol and alprenolol, but not other beta-blockers, stimulate cellular protective pathway in the heart.
S14	Hospitals and nursing homes contribute to water contamination with pharmaceuticals through their disposal methods.
S11	Rituximab prescribing info revised to reflect risk of progressive multifocal leukoencephalopathy.
S10	Molecular mechanism of steroid-induced fatty liver determined.
S10	Pentazocine shows encouraging results in a mouse model of diabetic retinopathy.
S09	Serotonin transport receptor levels in the brain change with the seasons; may reflect seasonal affective disorder.
S08	Once-a-week sustained release exenatide lowers HbA1c better than twice daily shots.
S08	Genetic variants associated with markedly different vitamin B12 handling.
S05	Bisphenol (present in polycarbonate plastics) linked to metabolic syndrome.
S02	In vitro studies suggest role for antihistamine clemizole in treating hepatitis C
S02	AJKD: Temporary iron depletion and relative thrombocytosis may underline increased mortality with high doses of EPO.
A29	Singh and Furberg editorialize against use of thiazolidinediones due to CV risk and lack of CV benefit.
A26	Allopurinol lowers blood pressure in hypertensive adolescents
A26	Leptin injections keep rats with type 1 diabetes alive without insulin.
A26	Twenty percent of Ayurvedic medicines found to be contaminated with lead, arsenic, or mercury.
A22	Some evidence that Vytorin is, or maybe is not, associated with an increased cancer risk; FDA gets involved.
A22	New antimicrobial approach tames, rather than kills, pathogenic bacteria, lowering risk of emerging resistant strains.
A21	AMAG receives fast track designation from FDA for ferumoxytol as an MRI contrast agent.
A20	Individual genome analysis shows that drug sensitivity may be poorly predicted by skin color (presumed race)
A19	Effect of grapefruit juice on drug absorption and metabolism: new complexities
A18	Researchers create milligram quantities of completely synthetic heparin
A14	SpyCEP identified as key element to infectivity of group A strep associated with necrotizing fasciitis.
A07	Bile acids play a role in glucose metabolism and insulin signaling.
A01	FDA forces new labeling changes for ESAs under new law.
J31	Two new drugs have profound effects on exercise conditioning in mice.
J23	NEJM: Genetic mutation associated with most patients who develop myopathy on high-dose statins.
J22	House Appropriations Subcommittee increases proposed FDA budget by more than 20% to over 2 billion dollars per year.
J21	Anti-bacterial actions of cranberry juice explained by its action on fimbriae.
J16	Doctors hopeful that improved blood thinners are on the horizon: Three new candidates.
J13	Histone deacetylase (HDAC) inhibitor SAHA found to have anti-immune effects in graft vs. host disease.
J11	FDA lists May 2008 labeling changes: Aranesp (tumor progression) and CellCept (lymphoma and PML risk)
J10	Aspirin may benefit patients with osteoporosis: a possible mechanism identified.
J10	Histone deactylase (HDAC) inhibitors protect ischemic tissue from injury.
J09	Fresenius signs sublicensing agreement with Luitpold to use Venofer in United States patients.
J08	Stanford researchers find molecule that kills kidney cancer cells, STF-62247.
J08	FDA adds boxed warning on risk of tendon rupture associated with fluoroquinolone antibiotics.
J07	Fresenius Medical buys heparin-maker APP pharmaceuticals.
J03	Statins spur glial progenitor cells to develop into oligodendrocytes.
J03	Pfizer will no longer work directly with for-profit CME companies.
J03	FDA panel recommends that all new diabetes drugs be screened for cardiovascular risk.
J02	New orally active, broad-spectrum angiogenesis inhibitor may be useful against many cancers.
J28	Bill to approve pathway for FDA approvals of biosimilars advocated as saving billions of dollars.
J26	Two siRNA in the Phase I/II pipeline for kidney disease, one for delayed graft function, the other for AKI
J24	Take your meds and have a chance at winning the lottery.
J23	Rapamycin may impact retardation in tuberous sclerosis and might be useful in treating autism.
J19	FDA cautions about increased mortality in elderly patients with dementia who had been treated with antipsychotic drugs
J18	Computer generated warfarin dosing as effective as dosing by expert prescribers.
J13	FDA and EMEA to consider biomarkers of renal injury in animal studies evaluating renal safety of new drugs.
J12	XBP1, stimulated by a high-carb diet, may be a new target for treatment of dyslipidemias.
J12	FDA approves generic form of ramipril made by Lupin pharmaceuticals.
J11	CMS gives researchers access to parts of the Medicare prescription drug benefit database.
J05	FDA: More on the ongoing review of TNF-blockers and cancer risk.
J05	Study in mice suggests resveratrol has marked cardioprotective effects.
M23	FDA to use Medicare claims data to monitor drug side effects once drugs have been marketed.
M19	Protein the mimics phagocyte defensins effective against resistant bacteria on in vitro testing.
M18	New superdrug may be useful against MRSA superbugs.
M17	FDA convenes to examine impact of direct-to-consumer pharmaceutical, and now, medical device, advertising.
M13	Texting kids to take their medicine may increase compliance.
M09	Darapladib lowers the activity of inflammatory enzyme associated with vascular plaque.
M05	ASN Renal Week abstract archives 2003-2006 now available on-line in .pdf format.
M02	New ACE 2 activator compounds lower blood pressure in rats and also reduce cardiac and renal fibrosis.
A28	FDA approves Relistor (methylnaltrexone) for opioid-induced constipation.
A25	First ever activator of ENAC sodium channel developed.
A24	GAO says that FDA lacks resources to inspect non-US drug suppliers; only 8% are being inspected now.
A23	Genzyme to build new research and development center in Beijing.
A23	Some compounds in Chinese bitter melon identified with activity against diabetes.
A22	CMS releases standards for e-prescribing of drugs.
A21	Massachusetts Senate unanimously passes a law banning all pharma gifts to doctors.
A19	Democrats propose labeling requirements for food and drugs which would list country of origin.
A10	FDA notice regarding investigation of mycophenolate mofetil regarding progressive multifocal leukoencephalopathy.
A07	New antimicrobial proteins identified in alligator blood
A04	AMAG Pharma presents data on new iron supplement at NKF Spring Clinical Meeting.
A03	New Merck heart failure drug rolofylline gives encouraging results in Phase III trial.
M27	Keryx ends development of sulodexide after negative trial results.
M19	Roche agrees to pay Amgen 22.5 percent royaty on Mircera sales in the U.S.
M13	FDA Oncologic Drug Advisory Panel recommends continued indication of ESAs for cancer patients excluding breast and head and neck.
M12	Keryx diabetes drug sulodexide fails to achieve primary endpoint in phase III clinical trial.
M11	Eli Lilly follows Pfizer and NovoNordisk in discontinuing inhalable insulin.
M10	FDA plans to ease restrictions on dissemination of reprints by pharma involving off-label usage of drugs.
M07	Bill to encourage e-prescribing for Medicare-reimbursed encounters likely to pass this year.
M06	More on the heparin contaminant in Baxter's product line - still unidentified.
M05	Massachusetts may ban drug industry freebies for docs.
M05	Supreme court votes 4 vs. 4 regarding pharma immunity from product liability for FDA-approved prescription drugs.
M05	FDA finds possible contaminant in Baxter heparin.
M05	Sensor necklace and magnetic trace additive to pills might be used to track medication compliance in clinical trials.
F27	Supreme Court hears arguments as to whether pharma companies should be protected from torts when a drug has been approved by the FDA.
F26	FDA: Medication guide must be given to patients with each rosiglitazone (Avandia) prescription.
F20	AMAG submits NDA to FDA for ferumoxytol.
F16	FDA issues draft guidelines for comment to Pharma about distributing reprints describing off-label usage of drugs.
F16	Baxter heparin case calls attention to Chinese chemical companies supplying drug raw materials with minimal regulation.
F16	Promising early data from another prostate cancer vaccine trial.
F15	Some cholesterol synthesis inhibitors also block Staph. aureus pigment synthesis, rendering the germ less pathogenic.
F07	FDA warns on adverse effects due to intravenous colchicine.
F01	Anti-leishmaniasis drug miltefosine kills HIV-infected macrophages, eliminating one protected site of HIV persistence.
J28	Vytorin lowers cholesterol, but does not impact on endpoints; House asks FDA to reconsidering hard vs. soft endpoints in proving drug value.
J25	Cox-2 inhibitors can cause arrhythmias by affecting potassium channels in the heart.
J16	FDA warns of name confusion between two edetate compounds used for chelation.
J11	Gas6 protein may augment the action of erythropoietin
J09	Cannabinoid receptor blocking drug effective in causing weight loss.
J02	Labeling on adrenaline vials in terms of concentration are confusing, lead to errors.
J02	European study could find no link between non-phenacetin pain killers and ESRD
D27	FDA approves synthetic starch-based volume expander fluid.
D27	New orally active cyanide antidotes discovered.
D21	Animal study suggests that EPO may protect hearts against toxicity of anticancer drugs
D20	FDA issues draft guidelines to industry for reporting adverse events linked to OTC drugs and dietary supplements.
D19	Northwestern University gets 700 M royalties for diabetes pain drug patent.
D19	AMAG pharma submits new drug application to FDA for ferumoxytol.
D17	US House Rep Waxman leaks FDA planned guidance to OK drug company promotion of off-label uses of drugs.
D17	Drug that stimulates thyroid hormone beta receptors effective in lowering LDL cholesterol
D15	U.S. FDA considers allowing a new group of -behind the counter- drugs to be dispensed with pharmacist approval only.
D14	FDA warns of serious adverse reactions with iron chelator Exjade.
D08	FDA launches new drug safety newsletter. Here is the first issue (rituximab)
D05	Dennis Quaid sues Baxter over label similarities between low- and high-dose heparin vials.
D04	FDA approves study of iron-containing dialysate additive for hemodialysis patients.
D03	Pharma companies to develop IgA proteases as a potential treatment for IgA nephropathy.
D03	Topical cleaners containing benzethonium chloride bactericidal against MRSA.
N27	FDA: Use of mycophenolate mofetil during pregnancy associated with increased risk of pregnancy loss and congenital malformations.
N26	Nitrosyl cobamide shows promise as an NO-donor type of drug for hypertension or heart disease.
N25	Executives from Genzyme and Johnson and Johnson to sit on FDA foundation board.
N16	CMS pushing e-prescribing for Medicare beneficiaries.
N16	Pramlintide-leptin combination drug induces 13% weight loss in obese patients.
N15	FDA approves Roche ESA anemia drug Mircera
N14	Cattle vaccine shown to be effective in lowering rate of toxigenic E. Coli carriage.
N14	FDA adds black box warning of heart attacks for Avandia (rosiglitazone)
N09	Placenta cloaks its proteins with phosphocholine (as do parasitic worms) to evade immune detection.
N08	FDA modified boxed warnings, indications, for ESA drugs.
N08	Skeletal muscle damage due to statins may operate through atrogin-1 and thus may be preventable.
N06	Shire announces results of Fosrenol trial in stage 3-4 CKD patients.
N05	New vascular function of hemoglobin, as a promoter of nitric oxide synthesis, identified.
N01	Legislation introduced in the House to fight spread of drug-resistant bacteria.
O29	Bacterial use peptides to communicate with each other: extracellular death factor identified.
O25	Bayer issues additional guidance to physicians about Trasylol (aprotinin).
O25	Genzyme launches cholesterol-binding drug (Cholestagel) in Europe for patients with primary hypercholesterolemia.
O25	SQ109, promising anti-tuberculosis drug, given special status by European and U.S. regulators.
O25	Genzyme profits increase tenfold on sales of drugs to treat rare diseases.
O23	Acute pancreatitis associated with exenatide (Byetta) - FDA requires labeling change
O19	Sudden hearing loss associated with erectile dysfunction drugs.
O17	Vaprisol (conivaptan) study shows increase in serum sodium in euvolemic hyponatremia.
O17	FDA advisory committee votes in favor of phosphate binder use for stage 4 CKD.
O16	FDA approves Doribax(tm) - doripenem - for complicated urinary tract infections, including pyelonephritis
O16	Velcade (bortezomib) for multiple myeloma now approved for use in patients with impaired renal function.
O12	FDA advisory meeting next Tuesday to study use of phosphate binders in pre-ESRD - Genzyme, Shire, Fresenius will all be present.
O12	Statins help preserve lung function during aging.
O08	New antibiotic ceftobiprole very effective in curing diabetic foot infections.
O03	Rockwell begins dosing patients with iron (soluble ferric pyrophosphate) - containing dialysate.
S25	New, synthetic version of heparin is patented.
S25	FDA to screen all direct-to-consumer (DTC) television ads if pending law is passed.
S20	Rockwell begins enrollment into Phase IIIb trial of dialysate sodium ferric pyrophosphate for iron therapy.
S11	Nabi to sell its Biologics division, and plans to move its headquarters.
S06	FDA approves first generic versions of carvedilol (Coreg).
A30	New mechanism of action of thiazolidinediones discovered.
A21	Unlike grapefruit juice, pomegranate juice does not appear to affect cytochrome P450-3A activity
A19	Bacteriophage treatments coming back into favor to combat superbugs such as MRSA.
A17	Patients who develop kidney failure after use of phosphate-based laxatives initiate lawsuits.
A17	FDA warning letter issued emphasizing pharmacogenomic variability in warfarin metabolism among patients.
A08	Annals: New study questions the increased heart attack risk with Avandia; original NEJM meta-analysis claimed to have been flawed.
A07	Publix supermarkets to offer up to 14-days of free antibiotics.
J30	FDA Advisory Panel to explore safety and risks of Avandia.
J24	Ferumoxytol Phase III clinical trial results achieve desired endpoints.
J21	New Cochrane analysis focuses on increased side effects in patients taking rosiglitazone (Avandia)
J19	Weight loss pill rimonabant associated with increased suicide risk.
J16	Older, cheaper pills just fine to treat diabetes.
J16	Affymax announces phase 3 development program for Hematide.
J12	Hydroxychloroquine (Plaquenil) may be protective against developing type 2 diabetes.
J09	FDA warning: precipitation when infusing ceftriaxone with calcium-containing solutions.
J27	Amgen makes labeling changes for Sensipar - no longer labeled for use in pre-ESRD patients.
J22	FDA approves pregabalin (Lyrica) for treatment of fibromyalgia.
J22	FDA clears "computerized medication box" (EMMA) for U.S. market.
J19	Randomization complete for phase III trial of sulodexide for diabetic nephropathy.
M23	Diethylene glycol - contaminated toothpaste linked to source in China
M23	Iron-chelating agent defasirox (Exjade) associated with acute renal failure.
M03	NEJM: Drug risks and free speech - can Congress ban direct-to-consumer ads?
A30	Compound from bullfrogs has marked anti-MRSA activity.
A07	Arthritis patients with CVD who take ibuprofen plus aspirin may greatly increase their cardiac risk.
M26	Tolvatptan improves signs and symptoms in patients with CHF.
M26	Nesiritide safety trial shows neutral effect on mortality in CHF patients
M22	FDA moves to limit participation of MDs with ties to pharma companies on its advisory boards.
M12	Azole antifungal drugs found to be active against tuberculosis.
M08	Indian pharma firm Biocon unveils suite of immunosuppressive drugs aimed at the transplant market.
M06	FDA approves aliskiren for treatment of hypertension.
M05	Taking amphotericin B in oil by mouth may result in good efficacy, less renal toxicity.
M02	NEJM: Vancomycin-induced thrombocytopenia: the article link
F28	NEJM: Immune-mediated thrombocytopenia linked to vancomycin use.
F23	MMWR: Nephrogenic fibrosing dermopathy.
F05	FDA approves new dosing recommendations for Rapamune (sirolimus) in high immunologic risk transplant patients.
F01	Biotrends report of Dec 2006 survey on use of ESAs and phosphate binders.
J16	DNA test to be used to determine warfarin dose.
J15	House passes Medicare drug bill.
J09	Two Wisconsin companies get together to develop ingested products for hyperphosphatemia control.
J09	Potential bias in studies funded by the food industry or by pharma in the news.
J04	Genzyme files new drug application with the FDA for sevelamer carbonate.
J03	Renal Advantage completes acquisition of Renalab.
D31	Gene knockout technology creates healthy, prion-protein-free cows
D29	FDA evaluating safety of products from cloned animals; seeks outside comments.
D28	Advanced Magnetics stock surges on hopes for ferumoxytol.
D22	FDA announces that it is still evaluating a possible link between MRA with gadolinium and nephrogenic fibrosing dermopathy.
D22	Multidrug resistant E. coli linked to antibiotic use on farms in the U.K.
D21	Genzyme files for FDA approval of sevelamer carbonbate - Renvela.
D20	FDA to require labeling changes for acetaminophen and for NSAIDs to highlight potential risks.
D16	FDA updates labeling for Trasylol (aprotinin) regarding risk of renal dysfunction, anaphylaxis, and re-exposure.
D12	Phase 3 trial shows Avastin (bevacizumab) improves progression-free survival in renal cancer patients.
D12	FDA campaigns against use of quinine for conditions other than malaria; cautions against use of quinine for leg cramps.
D11	FDA proposes rules overhaul to expand access to experimental drugs.
N30	Dynavax stock rises on news of positive results for Hepatis B vaccine in difficult to immunize patients.
N28	Genzyme researchers show promising results with drug against polycystic kidney disease.
N26	HDCN: Search index updated for audiofiles, slide/audio talks, articles, and abstracts
N18	CMS plans to open up physician-prescribing drug database to researchers
N14	Nabi reaches deal with hedge fund on directors, chairman.
N10	FDA approves pramipexole (Mirapex) for treatment of restless legs syndrome in nonuremics
N10	FDA considers expanding patient access to experimental medications
O30	Pharma supported patient education sites under the microscope.
O26	Phase 3 trial design for belimumab to treat SLE approved by FDA
O23	FDA approves once-a-day Coreg (carvedilol) CR for 3 cardiovascular indications
O18	Cockcroft Gault equation (modified) better than MDRD for adjusting vancomycin dose in the elderly.
O18	Rockwell submits dose ranging study for dialysis solution iron supplement to FDA
O17	FDA approves new treatment for diabetets - Januvia (sitagliptin)
O10	Biodegradable gel stops bleeding promptly
S28	Amgen colon cancer drug gets FDA approval
S28	Meditor working on development of intradialytic hypotension drug.
S27	U.S. House and Senate pass bill allowing purchase of drugs from Canada
S27	La Jolla Pharm announces addition of new sites, reactivation of Riquent (abetimus) study to treat lupus.
S26	Generex develops metformin-containing chewing gum, oral insulin spray, as novel drug-release products.
S19	FDA approves posoconazole to treat Aspergillus and Candida fungal infections.
S18	Food and drugs pass through the stomach very quickly or quite slowly.
S13	More bad news in JAMA paper about CV and kidney risks of COX-2 inhibitors and NSAIDS
S12	New class of pain relievers may help, not hurt, the heart
S11	Advanced Magnetic (ferumoxytol) hires Brenner, Salem, in top positions
S11	Bacterial conversation stoppers may block formation of biofilm
S11	Chitosan (from crabs and shrimp) found to block formation of biofilm.
S11	Want to fight fat? Eat brown seaweed!
S06	Advanced Magnetics completes enrollment for phase 3 trial of ferumoxytol IV iron.
S06	Virtually untreatable type of tuberculosis being identified worldwide
A24	FDA proposes system to systematically register and uniquely identify all drugs sold in the U.S.
A19	Spray on bacteriophages approved to control Listeria on meat; toxigenic E. Coli next on the list.
J31	Survey of FDA scientists documents political interference in drug approval process
J24	Rockwell gearing up to study efficacy of dialysis solution-based iron therapy.
J21	Fresenius to debut calcium-acetate / magnesium-carbonate phosphorus binder in Germany.
J20	New antibiotic tygecycline available in the UK to treat MRSA.
J10	Some drug metabolism / detoxification has a pronounced circadian rhythm.
J02	Cytochroma acquires Proventiv Therapeutics to commercialize new Vitamin D products for CKD market
J28	How to restrict access to your medication prescribing data
J28	Did you know that drug companies have full access to your medication prescribing data?
J20	ISMP and FDA issue medical abbreviation blacklist - QOD, IU, ug, qHS, all likely to cause errors (pdf)
J07	Congenital malformations with first-trimester ACE-inhibitor therapy.
J05	Isis Pharma gets orphan drug status for familial hypercholesterolemia drug.
J02	Heart attack risk with COX-2 broadened to include most NSAIDs
M17	Superbug slain by soil antibiotic
M15	Aspirin may protect against gentamicin-induced hearing loss.
M09	Getting rid of the furanocoumarins in grapefruit juice abolishes the juice's effects on CYP3A drug metabolism
M01	Astellas acquires rights to two new orally-active prolyl hydroxylase inhibitor drugs to treat anemia.
A26	GI hormone oxyntomodulin lowers appetite, increases activity level
A26	FDA approves first generic pravastatin.
A25	University of Michigan to pay for preventive diabetes meds for its employees.
A21	Orally available iron chelating agent desafirox shows promising results.
A20	Roche files with FDA for approval of its anemia drug CERA (continuous erythropoetin receptor activator)
A19	FDA grants priority review to Neurochem for Fibrillex - AA amyloidosis drug.
A13	FDA announces public meeting focusing on regulation of nanotechnology
M21	Nabi to resume development of Staph. vaccine.
M17	New vitamin D anticancer effects may be separable from its bone effects.
M15	Six men in monoclonal antibody drug trial critically ill.
M12	Losartan metabolite activates PPAR-gamma
M09	Nabi's NicVax (smoking cessation vaccine) given fast-track status by US FDA.
M06	Annals: Dramatic recent rise in community-acquired MRSA infections.
M03	Serotonin may play a role in hardening of the arteries.
M02	Hyperglycemia and hypoglycemia associated with use of gatifloxacin.
F24	FDA approves new antifungal drug (Eraxis) effective against serious Candida infections.
F24	Tolvaptan receives FDA fast-track approval status to treat polycystic kidney disease.
F21	Is there a way to avoid the bladder toxicity of cyclophosphamide?
F21	Alginate-encapsulated pancreatic islet cell transplants for diabetes.
F13	Neurochem submits Fibrillex to the FDA for control of AA amyloidosis
F06	Synthetic heparin could replace animal-derived drug.
F01	Nabi announces fast tracking of hepatitis C immune globulin by the FDA to prevent HCV reinfection.
J28	Baxter mourns death of William Graham, pioneer and leader in healthcare.
J28	FDA approves first ever inhaled insulin for the treatment of diabetes.
J26	FDA approves Sutent - new angiostatin treatment for metastatic kidney or stomach cancer.
J26	Aprotinin (Trasylol) linked to increased risk of kidney failure, heart attack and stroke.
J24	Alagebrium (a collagen cross-link breaker) softens arteries - and that's good for you.
J24	Archives: Chronic warfarin use increases risk of bone fracture.
J23	Annals: Liver failure and hepatitis from telithromycin.
J22	AHA review casts doubt on cardiovascular health benefits of soy-based foods.
J21	British study shows that work stress linked to both heart disease and metabolic syndrome.
J21	Medicare Part D changeover leaves some Florida patients without payments for transport to dialysis.
J19	New drug label rule intended to reduce medical errors.
J19	Study of drug resistance among bacteria found in soil can potentially guide new drug development.
J19	Commonly used antidepressants may also affect the immune system.
J19	MMWR: Type A influenza highly resistant to amantadine derivatives
J18	Rockwell Medical Technologies gets rights to market vitamin- and carnitine-supplemented dialysate.
J17	Anti-obesity drug from cannabis really works?
J16	Canadian study suggests higher mortality among diabetics treated with sulfonylurea drugs vs. metformin.
J15	Acetazolamide reduces sleep apnea severity in heart failure patients.
J15	Hypothalamus has a fatty acid sensor that may regulate food intake
J07	CJASN: Diagnostic and Therapeutic Corner: HAART and the Kidney
J07	Brain protein (p11) may play a critical role in depression.
J06	Post-marketing data detects new onset / worsening of macular edema in patients taking Avandia (rosiglitazone).
J05	MRSA patterns in ICUs changing: 64% prevalence rate, hardier, bugs, but less multi-drug resistance.
J04	FDA approves conivaptan (Varprisol) for treatment of euvolemic hyponatremia in hospitalized patients.
J04	Adenosine receptor antagonist completes phase 2 trials for congestive heart failure.
D27	Acetaminophen can cause acute liver failure when usual dose is even slightly exceeded.
D26	Dalbavancin (a vancomycin-like drug) effective in mice against anthrax.
D17	Heteropolymer antibodies - a new approach to treat and prevent? MRSA infections.
D17	CDC recommends new blood test to diagnose TB infection.
D14	Amgen buys Abgenix, maker of panitumumab (colon cancer drug).
D12	Oral endothelial receptor antagonist ambrisentan effective in pulmonary HTN.
D11	Pramexipole for restless legs syndrome in nonuremics.
D10	Encyclopedia of traditional Indian medical knowledge to be on the internet.
D03	Random testing shows high lead levels in some imported Chinese plums.
N28	Higher dose of Fosrenol (lanthanum carbonate) approved by FDA for ESRD patients.
N17	Oralyn, an oral insulin-like drug, to be launched this month in Ecuador.
N17	Tea, cinnamon, buckwheat, and cherries for diabetics.
N17	AHA: CV mortality benefits of diuretics linked to alpha-adducin genotype.
N16	AHA: Aliskiren (renin inhibitor) adds to anti-HTN effects of irbesartan.
N12	Risk-stratified analysis proposed to analyze RCTs to detect harm.
N07	AAKP info sheets on Medicare Part D drug benefit for kidney patients.
N06	More on the new FDA digital drug label submission requirement.
N06	New FDA-supported website lists latest approved drug labels for all meds.
O30	Making sense of the new Medicare Part D drug plan.
O28	FDA delays decision on approving inhalable insulin
O27	New endogenous carbohydrate (INS2) discovered that lowers blood glucose.
O26	ASN Renal Week 2005 abstracts now available on-line.
O24	Shire highlights publication of 1 and 3-year Fosrenol extension study.
O20	Tigecycline may offer promise to treat MRSA and vancomycin-resistant bacteria.
O18	RPA compiles info on Medicare D drug benefit plan on its website.
O12	New defensin-class antibiotic isolated from pine forest fungus.
O05	Generic form of amlodipine approved by the FDA
S29	JASN: Acute phosphate nephropathy following certain bowel preps.
S28	Toprol (metoprolol)/Topamax/Tegretrol look-alike names prompt FDA alert letter.
S28	Nabi sues Ohio company for patent infringement over generic calcium acetate.
S26	Genzyme could see upside if Renagel included in Medicare Part D.
S25	Genes on chromosome 2 linked to resistant hypertension.
S22	Affymax launches phase 2 study of NESA to treat anemia in European CKD patients.
S22	Pharma organization launches global clinical trials database.
S21	Nabi launches study to see if StaphVax will protect dialysis patients long-term.
S20	Novartis oral renin inhibitor aliskiren shows good results in phase III trial.
S13	Pioglitzaone improves cardiovascular outcomes in diabetics.
S11	FDA approves first glitizar-class drug for treatment of type 2 diabetes.
S09	FDA advisory panel recommends approval of inhaled insulin.
A28	Medicate part D to help cover costs for kidney patient drugs.
A25	Ten Canadian pharmacies apply for license to sell Rx drugs in Nevada.
A22	Scios announces recommended use initiative for Natrecor.
A22	Long-acting form of exenatide works in type 2 DM; Amylin shares soar.
A19	Jury awards widow 253 million in Vioxx suit against Merck.
A19	Magnetic nanoparticle MRI used to visualize inflammed pancreas in type 1 DM.
A19	Myogen announces phase 2 trial results of darusentan in resistant hypertension.
A19	Novartis trying to develop alternative phosphate binding drug.
A18	Will FDA approve diabetes-related health claims for chromium picolinate?
A16	Do clinical trial docs leak info about new drugs to stock brokers?
A16	Analgesic drug use linked to high blood pressure in women.
A16	Kidney Drug Coverage website: Teleconference schedule
A11	Following clinical guidelines in elderly can lead to polypharmacy.
A11	Pfizer files for FDA approval of new renal cancer drug Sutent.
A02	Op-Ed piece suggests the FDA should loosen up; allow patient to choose some risk
J28	Drug dose adjustment in CKD: Guru texts may not agree.
J28	FDA bans use of Bayer fluoroquinolone in poultry to fight rise in superbugs.
J23	Is your clinical trial registered? If not, you may not get it published!
J22	Nabi initiates phase 1 trial of vaccine against another strain of S. aureus.
J22	Retinol-binding protein implicated in obesity, insulin resistance.
J19	Reductions in Medicare payments for IVIG lead to problems: Portent for EPO?
J19	Annals: If Medicare were to provide ACE-I for free, it would be cost effective.
J19	Natrecor (nesiritide) safety summary (Scios)
J14	NIH finds ethics violations by its employees in 44 cases.
J14	NEJM op-ed piece attacks continued use of nesiritide.
J14	New super-EPO (PT-401) drug under development.
J14	Genzyme on a roll - good financial results, drugs in the pipeline.
J13	Nabi says Staph vaccine ups immunity.
J11	Q-med gets funding to further develop Ixion's oxalate technology.
J11	Carotenoids give gold color to S. aureus, and protect it from oxidation by WBCs.
J08	Genomic mechanism of increased azathioprine toxicity identified.
J07	Phase 3 trial begins of endothelin A receptor antagonist in diabetic nephropathy
J06	House bill to mandate reporting of all pharma clinical trials in registry.
J06	Law introduced to help prevent counterfeit drugs, especially EPO.
J06	Growth hormone releasing factor may prevent malnutrition in stage IV CKD.
J04	Medlearn matters (SE0541) Medicare Prescription Drug Coverage
J30	Canadian Health Minister to restrict U.S. access to Canadian meds.
J29	Consumer reports announces "best buy" calciuim channel blockers.
J29	Keryx initiates phase 4 study of sulodexide to treat diabetic nephropathy.
J28	Pfizer review claims no link between Viagra use and blindness.
J27	Will a next-generation HBV vaccine be more effective? Trial in progress.
J27	Omiganan topical antibiotic designed to prevent central venous catheter infxns.
J24	Canada aims to curb internet drug trade.
J18	Acologix and Toray team up to commercialize uremic itching drug.
J14	Large multinational study shows restless legs syndrome common in nonuremics.
J04	Editorials, opinions (via Kaiser) on disclosing results of clinical trials.
J03	Kaiser electronic med system reduces medication errors in CKD patients.
M27	FDA investigating causes of blindness in users of Viagra/Cialis.
M26	Deep sea bacteria may provide new tools to kill MRSA.
M24	Crestor (rosuvastatin) associated with higher adverse event risk.
M20	Nabi ramping up large scale production of its Staph vaccine.
M19	New way of fighting antibiotic resistance - by blocking evolution in E. Coli.
M13	Naturally occurring nanovaults eyed as vehicles to deliver gene/tumor therapy.
M12	Neurochem to plead its case before the FDA for Fibrillex approval.
M09	Two studies document the rise of superbugs in the environment.
M05	Pollen, leaves from lilies cause acute renal and liver failure in cats.
M03	Consumer Reports website suggest Best Buys for ACE inhibitors.
M01	Sen. Frist explores idea of a ban on direct to consumer pharma advertising.
A27	Combo Vytorin (ezetimibe + simvastatin) lower CHO better than atorvastatin alone
A27	Indirect evidence that NSAIDS may prevent age-related macular degeneration.
A21	Shire to acquire Transkaryotic - gets into anemia market with DYNEPO.
A20	Nesiritide associated with an increased death rate in CHF patients.
A19	Neurochem announces preliminary results on Fibrillex for AA amyloidosis.
A18	Tougher CME conflict of interest rules take effect.
A18	Melbourne researchers develop safer and more effective "aspirin".
A13	Bugs in the gut could help doctors develop individualised healthcare
A07	Pfizer suspends sales of COX-2 inhibitor Bextra at the request of the FDA.
A07	FDA issues new rulings on NSAIDs - remove some, black box warnings for others.
A05	Genzyme launches phase 3 study of tolevamer to treat C. difficile
A01	Best buy recommends best value beta-blockers.
M21	Nesiritide associated with risk of reduced kidney function in CHF patients.
M18	Potential anti-prostate cancer effects of celecoxib.
M17	FDA approves Symlin to help manage diabetes.
M05	Pfizer working on new drug that raises HDL cholesterol.
M04	Curis issued patent for use of BMP-7 to treat CKD.
M02	FDA posts warning: Reduce starting dose of Crestor in Asians.
F21	Big three automakers launch e-prescribing initiative.
F17	Vitamin D may ward off prostate cancer.
F15	Teva announces US launch of recombinant growth hormone for short-stature kids.
F15	Hepatitis B vaccine administered orally via potatoes.
F15	US FDA to create an independent drug safety monitoring board.
F11	Meta chip provides quick, effective toxicity screen for new drugs
F11	Progress toward new remedy for chronic urinary tract infections.
F03	Another lanthanum-based phosphate binder in development.
F03	Microdosing used to study pharmacokinetics of new renin inhibitors.
J25	In retrospect, Vioxx may have caused many heart disease deaths.
J24	Amgen involved with new stem cell company, ViaCell, with IPO today.
J20	Merck threatens to cut off supply to Canadian pharmacies that sell to U.S.
J20	NEJM: Aspirin/esomeprazole better than clopidogrel for CV risk prevention.
J19	Amgen's next blockbuster drug - for osteoporosis.
J17	Data entry is top cause of medication errors.
J17	FDA requires handout be given to patients receiving amiodarone.
J17	Drfug reimportation faces new hurdles.
J15	FDA public meeting on COX-2 safety set for Feb 16-18
J15	FDA panel rejects OTC sale of statin drug made by Merck
J13	Advanced Magnetics initiates large-scale trial of ferumoxytol IV iron.
J11	Death in patient taking Crestor who had rhabdomyolysis.
J11	NIH implements royalty disclosure policy among its staff.
J10	NABI: Staph. aureus immune globulin treated patients leave hospital sooner.
J06	Pharmacy prescription errors increase at the start of each month.
J06	Canada considers shutting down internet drug trade.
J06	Publication bias in the news - leads to incorrect regulatory decisions.
J04	Long-term NSAID use linked to small intestinal damage, bleeding.
D28	Voriconazole gets FDA approval for treatment of Candidemia.
D23	FDA clears genetic test for cytochrome P450 variants involved in drug metabolism
D23	Teva pharma reacquires marketing rights to IV calcitriol in the U.S.
D22	Aspirin underused by people with diabetes.
D22	Pharma industry awaiting Michael Moore's new documentary film with trepidation.
D21	Nabi Pharma requests European regulatory approval for its StaphVAX product.
D21	Naproxen linked to increased risk of heart attack,stroke
D19	Consumer Reports: How to save money on buying statins.
D19	Consumer reports BEST BUY website now operational
D04	Gene identified that makes biofilm bacteria hibernate and evade antibiotics.
D02	Consumer Reports to launch BEST BUY prescription drug price comparison website.
N26	WHO warns of bird flu and possible upcoming flu pandemic.
N24	Carbonic anhydrase inhibition linked to retinitis pigmentosa
N10	Pfizer COX-2 inhibitor also doubles risk of heart complications
N07	U.S. FDA to focus more on safety of marketed drugs
N05	Mutant mushrooms trigger brain disease in Japanese dialysis patients
O24	New TB vaccine shown to be safe
O24	More on the Japanese dialysis patients with mushroom-associated illness
O22	Japanese CKD patients become ill after eating apparently non-poisonous mushrooms
O14	Nightline on ABC covers drug reimportation: video of Frist vs. Stabenow
O14	AAKP requests open formulary for kidney patients without restrictions
O10	Massachusetts e-health network to go live in 2005
O06	Bugs in the gut can influence the body's response to disease
O06	One in six chronically ill adults skips Rx due to cost
O05	Pyridostigmine effective in combatting orthostatic hypotension
O02	Miniature swimming robot might be used for drug delivery
S30	FDA comments on voluntary Vioxx withdrawal
S30	Merck recalls Vioxx (rofecoxib) worldwide over concerns of increased CV risk
S20	Progress made on drug trial registry
S20	New British Approved Names (BANs) for generic drugs
S12	Company making fake urine for research
A21	Vermont sues FDA over block of Canadian drug imports
A18	Illinois governor announces extensive prescription drug reimportation program
A17	Newspaper examines industry bias in reporting sponsored trial results
J26	Pharmacy benefit managers a growing force in Medicare
J13	New and old ways to get lead poisoning: dinner plates and Ayurvedic medicine
J07	Methotrexate use in dialysis patient may have led to patient's death
J28	NY Times investigates drug company payments for prescribing interferon for HCV
J25	U.S. consumer group argues that Crestor (rosuvastatin) is unsafe
M01	Medicare Prescription Drug Assistance Program website
M26	Packaging for Na/K too similar; needs to be differentiated
M20	Labeling similarity of Baxter sodium, potassium products questioned in Calgary
M20	Calgary pharmacy potassium-sodium mixup happened before
J09	Story on Genzyme and its plans for future products
N26	FDA labeling change for lovastatin re myopathy / liver function
N26	FDA labeling change for simvastatin re myopathy / rhabdomyolysis
O21	FDA medwatch safety labeling changes (incl. lisinopril, enoxaparin)
O19	US prescription drug system under attack
O17	AJM: Drug promotion, rather than study publication, influences usage patterns
J06	Astoundingly high levels of mercury found in whale organs
D04	Red wine consumption interferes with cyclosporin availability
O29	Corey Nahman Pharmacy News