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HDCN News Archive -- CRRT / Acute Renal Failure
J03 NEJM: Scanning the blood for circulating tumor cells using DNA technology helps guide treatment of metastatic disease.
J03 VA/NIH study of dialysis dose in acute kidney failure published in NEJM
J03 Novel antibiotic ceftobirole kills even the most resistant Staph. aureus.
J01 Indocyanine green plus laser light kills even resistant bacteria; application to wound infections.
J26 Two siRNA in the Phase I/II pipeline for kidney disease, one for delayed graft function, the other for AKI
J26 Cethromycin for community-acquited MRSA.
J25 MRSA skin infections becoming commonplace in healthy athletes.
J25 Radiofrequency equipment ID tags can halt dialysis machines, change ventilator settings, alter syringe pump performance in the ICU.
J19 Some pathogenic bacteria use nanosyringe to inject host cells with toxins.
J18 Computer generated warfarin dosing as effective as dosing by expert prescribers.
J18 HHV-8 herpes virus linked to ketosis-prone type 2 diabetes in Africa.
J16 Do patients with combined liver/kidney transplants really need the kidney portion?
J13 FDA and EMEA to consider biomarkers of renal injury in animal studies evaluating renal safety of new drugs.
J06 Nephros completes trial of clip-on hemodiafiltration module and high-efficiency b2-M hemodiafilter.
J05 NEJM: Heparin contaminated with oversulfated chondroitin sulfate causes anaphylaxis via kallikrein activation.
J03 Antibacterial wipes can actually spread drug-resistant bacteria if used on more than one surface.
J03 Salmonella outbreak in 9 states linked to raw tomatoes.
J03 Nova (R) renal - a contrast-free method for visualization of renal perfusion on MR scans.
J03 Magnetic control mechanism developed to steer swallowed mini-cameras for better GI tract images.
J03 Artificial blood vessel creation from smooth muscle cells makes major advances.
M30 Cause of clubbing of the fingers in lung disease found - 15-HPGD.
M28 RIP140 molecule involved in tumor cachexia, fatty liver, and associated inflammation.
M27 New scoring method for coronary artery calcification that takes into account extent of calcium coverage.
M23 Automated CPR machine helps save lives.
M22 FDA approves gut opioid antagonist Entereg, for use to prevent postoperative ileus.
M20 NEJM: Palevsky-VA/NIH study shows that daily HD or more intense CRRT of no benefit in acute kidney injury
M19 Results of VA/NIH study on dialysis dose in acute kidney injury to be presented tomorrow, May 20th, in Toronto at ATS2008.
M19 Silver-coated endotracheal tube use dramatically reduces resistant infections in ICU patients.
M19 Capsaicin plus a derivative of lidocaine cause pain relief without numbness. Will it work for cannulation pain?
M16 Salmlonella infection in people linked to exposure to dry dog food.
M16 MMWR: CDC recommends herpes zoster vaccine for all persons over age 60.
M15 Lower-dose tissue plasminogen activator treatment improves survival in patients with hemorrhagic stroke.
M15 Canadian scientists discover how tuberculosis bacteria evade destruction by macrophages.
M15 Fluvastatin found to markedly lower viral load in hepatitis C.
M13 Preop beta blockers reduce heart attack risk but markedly increase total mortality.
M12 CPR rescuers do not need to stop compression while administering defibrillator shocks.
M12 U.S. Health Secretary: Chinese heparin now should be safe.
M09 FDA reissues heparin alert, since contaminated heparin still stocked in a number of hospitals.
M07 New hospital superbug to worry about: Stenotrophomonas maltophilia
M05 ASN Renal Week abstract archives 2003-2006 now available on-line in .pdf format.
M02 Protozoans may ingest E. Coli, and carry them on the surface of vegetables like spinach and lettuce.
M01 MMWR: Acute renal failure associated with cosmetic soft tissue filler injections.
A28 New JAMA study to highlight CV risk of blood substitutes; FDA under renewed pressure.
A28 Hypertension seen in the emergency department frequently misattributed to trauma, stress, and not followed up.
A28 FDA approves Relistor (methylnaltrexone) for opioid-induced constipation.
A23 MIT led teams unravel heparin deaths mystery
A23 NEJM paper (full text) describes mechanism of how oversulfated chondroitin sulfate can cause anaphylaxis.
A23 FDA: Fatal hypoglycemia due to maltose-containing immune globulin causing erroneous blood glucose readings.
A22 FDA approves compact heart assist device from Thoratec.
A17 FDA critical path in process for evaluating biomarkers to detect kidney injury.
A15 FDA warns of selenium, chromium poisoning associated with health supplements.
A15 Archives Int Med: Loop diuretics associated with lower bone density in men.
A15 Salmonellosis associated with Malt-O-Meal cereal ingestion.
A15 FDA announces recall of two dietary supplements found to contain aristolochic acid.
A07 New antimicrobial proteins identified in alligator blood
A07 Mud bath clays may be useful to treat MRSA skin infections.
A03 New Merck heart failure drug rolofylline gives encouraging results in Phase III trial.
A02 Adenosine receptor antagonist shows promise in heart failure.
A02 ExoSeal vascular plug reduces bleeding after arterial catheterization.
A02 Iodixanol (Visipaque) no better in terms of contrast nephropathy for PCI.
A01 Should black box warnings on ultrasound contrast agents be reconsidered?
A01 Bacteriophage-bonded surfaces used in wound dressings to decontaminate MRSA.
M28 MMWR: Discharge diagnosis of kidney disease for hospitalizations increased fourfold between 1980 and 2005.
M27 NEJM: Diaphragm atrophy begins within 18 hours of mechanical ventilation.
M25 European nations recall heparin; safety of alternative heparin supply called into question.
M25 Archives paper highlights renal failure risk of oral phosphate colonoscopy preps.
M25 Inhaled hydrogen sulfide gas induces hypometabolic state in animal model.
M22 Heparin supplied by B. Braun also affected by allergic contaminant problem.
M20 Two week old blood associated with adverse outcomes when transfused.
M13 JASN early release: High dose continuous HDF at 35 ml/kg/hr no better than 20 ml/kg/hr.
M12 Uninterrupted chest compressions during CPR by paramedics lead to increased survival.
M11 Creatine found to be neuroprotective in mouse model of perinatal hypoxia.
M11 Doubts raised over benefits of MRSA screening of hospitalized patients.
M10 With increase in availability from alternative sources, Baxter recalls all heparin products.
M06 Cannabinoid receptor blocker rimonabant prevents ethanol-induced fatty liver in mice.
M05 FDA finds possible contaminant in Baxter heparin.
M04 JASN: Humes' tubular assist device lowers mortality in AKI.
M04 CAPON gene linked to QT interval and heart rhythm abnormalities.
F27 Chewing gum after bowel surgery shortens duration of post-operative ileus.
F27 Up to 20% of persons taking aspirin show no effect on their platelet function.
F26 WHO survey reveals that prevalence of multidrug resistant tuberculosis cases at new high.
F23 Arbios gets conditional approval from FDA to test artificial liver device
F20 JAMA: Metaanalysis shows that intermittent dialysis and CRRT for ARF lead to similar outcomes
F20 New study confirms increased risk of kidney failure and mortality with aprotinin.
F19 Annals: Meta-analysis supports use of acetylcysteine prophylaxis prior to giving radiocontrast.
F15 Some cholesterol synthesis inhibitors also block Staph. aureus pigment synthesis, rendering the germ less pathogenic.
F11 Integrin receptor linked to HIV infection and replication in the gut. Is a treatment already available?
F07 NEJM full text of paper describing new arenavirus in patients dying after kidney or liver transplants.
F05 FDA cautions about severe tissue injury after intravenous administration of promethazine (Phenergan).
F04 CDC ongoing investigation into heparin anaphylactoid reactions summarized in MMWR
F01 Anti-leishmaniasis drug miltefosine kills HIV-infected macrophages, eliminating one protected site of HIV persistence.
J29 Intravascular thrombolytic therapy effective against deep vein thrombosis.
J28 More info about the Baxter recall of 1,000 IU/ml heparin vials due to anaphylactoid reactions.
J25 Update on Baxter heparin recall - one death may have resulted from first-use type anaphylactic symptoms.
J25 Cox-2 inhibitors can cause arrhythmias by affecting potassium channels in the heart.
J24 NEJM: Renal failure due to oxalosis after 2g/day vitamin C for 3 years in a renal transplant patient.
J22 Feeding cattle with ethanol distillation by products (distillers grains) increases risk of toxigenic E.Coli colonization.
J22 Aspirin resistance increases risk of heart attack or stroke.
J22 FDA approves new bioimpedance-based non-invasive cardiac output monitor.
J18 Canadian study suggests drinking 4 liters of water per day can cause proteinuria; reversible when water ingestion reduced.
J16 FDA warns of name confusion between two edetate compounds used for chelation.
J15 Monkey malaria widespread in humans in Southeast Asia - potentially fatal.
J02 FDA clears quick molecular-biology-based blood test for MRSA.
J02 European study could find no link between non-phenacetin pain killers and ESRD
D27 Researchers block liver cirrhosis in a mouse model by use of RSK inhibitory peptide which blocks collagen synthesis.
D27 FDA approves synthetic starch-based volume expander fluid.
D27 Weight-based dosing for ribavirin increases efficacy against hepatitis C.
D27 New orally active cyanide antidotes discovered.
D19 Controlled trial of controlled fluid challenge device (RenalGuard) during contrast infusion to begin.
D15 Sutent (sunitinib), a cancer-fighting tyrosine kinase inhibitor, associated with cardiac toxicity
N28 Eltrombopag increases platelet count in hepatitis C infected patients being treated with antiviral drugs.
N28 Crystal nephropathy due to combination of melamine and cyanuric acid responsible for renal failure in pets eating contamined food.
N27 Glucose-insulin-potassium infusion after ST-elevated MI increases risk of heart failure.
N26 Risk of acute renal failure after non-cardiac surgery in patients with prior normal function is about 1%.
N20 Nephros gets approval to market high-efficiency hemodiafiltration device in Canada.
N19 First-ever trial of RNA interference drug in humans targets acute kidney failure.
N16 MMWR: Severe acute respiratory disease, including death in healthy persons, due to adenovirus 14.
N14 Cattle vaccine shown to be effective in lowering rate of toxigenic E. Coli carriage.
N14 Nephros reports Q3 results
N12 Baxter receives 510k clearance for FDA to test a silver-coated IV line luer-lock connector.
N12 Patent extends principle of self-winding watches to heartbeat powered pacemakers.
N09 Lower abdominal pain in women after binge drinking may be due to bladder rupture.
N08 FDA clears silver-coated endotracheal tube for marketing.
N07 Survival doubles with adoption of new AHA resuscitation guidelines.
N07 New diagnostic test for TTP (thrombotic thrombocytopenic purpura) to be available via Ohio State University.
N07 Perioperative beta-blocker therapy shows mixed results in large RCT.
N07 News is not so good relating to hard outcomes with longer-term treatment of hepatitis C with pegylated inferferon.
N03 General Mills recalls frozen pizzas sold under Totino's or Jeno's name, because of possible E. coli contamination in the pepperoni.
N02 Entecavir highly effective in reducing hepatitis B viremia to undetectable levels.
N02 NephroCor introduces enhanced urine analysis test (RenalVysion) for kidney disease
N02 Cell-to-cell transmission of hepatitis C virus helps it evade some of body's most potent defenses.
N01 New therapies for multiple myeloma result in increased survival.
O29 Maggots to treat diabetic foot ulcers infected with MRSA.
O29 Bacterial use peptides to communicate with each other: extracellular death factor identified.
O25 Bayer issues additional guidance to physicians about Trasylol (aprotinin).
O25 SQ109, promising anti-tuberculosis drug, given special status by European and U.S. regulators.
O23 Renal Solutions gets FDA 510k clearance for advanced sorbent dialysis machine enabling higher dialysate flow rates.
O23 How dangerous is plasma transfusion from women donors?
O19 ARDS of unknown etiology? Look for spirochetes in the peripheral blood smear.
O16 Velcade (bortezomib) for multiple myeloma now approved for use in patients with impaired renal function.
O08 Two studies emphasize importance of nitric oxide in red blood cells, and absence of NO in banked blood.
O08 Appendix may be a safe house for good bacteria.
O08 Cleveland Clinic scores 3.2 million dollar NIH grant to develop implantable bioartificial kidney
O03 Seven Indiana schoolchildren suffered kidney failure requiring dialysis due to toxigenic E. Coli
S27 Caffeine plus acetaminophen linked to liver damage.
S25 Toxin-producing E. Coli outbreak among schoolchildren in Galena, IN.
S25 New, synthetic version of heparin is patented.
S24 C. difficile prevalent in asymptomatic carriers - may account for difficulty in eradication.
S20 FDA Recall: B. Brraun normal saline flush syringes.
S20 Post-reperfusion heart damage largely prevented by hydrogen sulfide.
S18 Dole recalls packaged salad mixes because of E. Coli risk.
S06 New CPR method relies on compression of abdomen, increases CO by 25%.
A19 Bacteriophage treatments coming back into favor to combat superbugs such as MRSA.
A17 Patients who develop kidney failure after use of phosphate-based laxatives initiate lawsuits.
A02 unGAL shown to predict development of acute kidney injury in children
J20 FDA warns about botulism from hot dog chili sauce.
J19 Baxter issues Class I recall of its replacement IV infusion pumps.
J11 Shredded lettuce may be source of toxigenic E. Coli outbreak in Huntsville, AL.
J10 More than 1100 toothpaste tubes from China suspected to contain DEG confiscated in Connecticut.
J09 PNAS: Aristolochic acid in the pathogenesis of endemic Balkan nephropathy.
J09 Cause of Balkan nephropathy found - contamination of grain by Aristolochia clematis.
J09 FDA warning: precipitation when infusing ceftriaxone with calcium-containing solutions.
J09 Slime busting bacteriophage virus could clean up biofilm.
J07 Waging war on C. difficile - the deadliest superbug.
J02 Probiotics good for antibiotic-induced diarrhea
J29 Particulates released during renal artery angioplasty can impair kidney function.
J28 Distribution of made in China, DEG-contaminated, toothpaste, in the United States includes prisons and hospitals.
J28 Velcade (bortezomib) in combination with cyclophosphamide and prednisone for multiple myeloma.
J26 Ketamine abuse linked to bladder dysfunction.
J22 Dangers of children ingesting hand sanitizers with high alcohol content
J19 FDA approves ambrisentan for treatment of pulmonary artery hypertension.
J15 Ethylene-glycol contaminated toothpaste found in Baltimore, MD store.
J15 Family sues Con Agra over salmonella contamination of peanut butter that allegedly led to kidney failure.
J09 Methylsalicylate absorption from sports cream results in teenager's death
J02 FDA warns on toothpaste marketed in the U.S. that was made in China over DEG contamination fears.
M23 More on the FDA gadolinium-contrast agent warning
M23 FDA orders black box warnings for gadolinium-based MRI contrast agents regarding NSF.
M17 Lawmakers push for changes in food safety oversight.
M09 FDA issues warning about potential diethylene glycol contamination of glycerin.
A30 Guelph scientists explain how pet food tainted with melamine and cyanuric acid can cause kidney failure.
A30 Compound from bullfrogs has marked anti-MRSA activity.
A21 Abstracts from March, 2007 CRRT meeting in San Diego.
A18 MMWR: Severe community-acquired MRSA pneumonia in association with influenza.
A17 New hope for malaria treatment with synthesis of long-acting artemisinin-like trioxane drugs.
A05 Reperfusion with glucose responsible for brain damage after hypoglycemic coma.
M30 Function of Rh blood proteins discovered: link to ammonia excretion.
M29 Aspirin may cut Staph risk in dialysis patients with venous catheters.
M23 Aminopterin found in tainted pet food.
M21 FDA approves hydroxocobalamin to treat cyanide poisoning.
M21 Spraying "essential oils" into the air reduces prevalence of MRSA in a hospital setting.
M16 FDA issues Medwatch SafetyAlert on linezolid (Zyvox) due to increased mortality rate
M16 Substituting gallium for iron impedes growth of slime-forming bacteria.
M13 Copper in doorhandles and hospital fixtures may fight MRSA
M12 Azole antifungal drugs found to be active against tuberculosis.
M09 MMWR reports on invasive MRSA infections in dialysis patients.
M08 UK National Health Service launches tool to help prevent infections in dialysis units.
M05 Taking amphotericin B in oil by mouth may result in good efficacy, less renal toxicity.
M03 Search Society for Interventional Radiology abstracts (2002-2006) (use keyword -dialysis-)
M02 NEJM: Vancomycin-induced thrombocytopenia: the article link
F28 Abstracts from 2007 CRRT meeting, March 7-10 in San Diego, CA
F28 NEJM: Immune-mediated thrombocytopenia linked to vancomycin use.
F26 Distinctive odor of diarrhea may lead to rapid diagnostic test for Clostridium and Campylobacter infection.
F04 Annual Dialysis Conference 2007 abstracts (Denver, Feb 18-20, 2007)
F04 International Center / Website for nephrogenic fibrosing dermopathy.
J29 Nephros gets conditional FDA approval to test hemodiafiltration module in the US
J29 Bacteriophages and antibiotics exhibit synergistic effect; may lower needed dose by a factor of 50.
J28 New necrotizing toxin identified in dangerous, community acquired strain of multidrug-resistant Staph. aureus
J26 Radiology journal to recommend avoiding gadodiamide in patients with kidney disease because of nephrogenic systemic fibrosis
J19 Potentially lethal strains of MRSA spreading to the community in the UK
J17 Hyperimmune response to 1918 flu virus is what made it so deadly.
D27 Cattle vaccine against E. Coli O157:H7 approved for use in Canada.
D22 FDA announces that it is still evaluating a possible link between MRA with gadolinium and nephrogenic fibrosing dermopathy.
D22 Prion-binding protein successfully removed variant CJD prions from banked animal blood.
D22 Multidrug resistant E. coli linked to antibiotic use on farms in the U.K.
D20 FDA to require labeling changes for acetaminophen and for NSAIDs to highlight potential risks.
D16 FDA updates labeling for Trasylol (aprotinin) regarding risk of renal dysfunction, anaphylaxis, and re-exposure.
D15 Common cold rhinovirus leads to death in two lung transplant recipients
D14 Role of heat shock proteins and fever in fighting infections clarified.
D04 New diagnostic recommendations published for diagnosis of pulmonary embolism.
D04 Toxigenic E. Coli outbreakds in New Jersey and Long Island linked to fast food outlets.
N26 HDCN: Search index updated for audiofiles, slide/audio talks, articles, and abstracts
N15 Tolvaptan paper published in NEJM - novel treatment for hyponatremia.
N07 Endotoxin core in bacteria linked to plant chloroplasts
O30 Vaccine protects mice against multidrug resistant Staph aureus.
O24 RCT initiated to study benefits of endovascular cooling during catheterization to prevent RC nephropathy
O13 Diethylene glycol-tainted cough syrup cause of multiple deaths, renal failure, in Panama.
O12 Human carriage of drug-resistant microbes linked to consumption of poultry
S28 Invasive streptococci produce a protein that destroys interleukin-8 and impedes WBC recruitment.
S27 CDC-MMWR: O157:H7 infections associated with consumption of fresh spinach.
S16 Spinach E. Coli scare grows
S15 Toxigenic E. Coli outbreak tied to bagged spinach - people affected in 8 states.
S13 More bad news in JAMA paper about CV and kidney risks of COX-2 inhibitors and NSAIDS
S11 New genetic method to detect early multiple myeloma
S08 MMWR: Locally acquired, mosquito-transmitted malaria in California and other states.
S05 U.S approves humanitarian use of Abiocor permanently implanted total artificial heart.
A19 Spray on bacteriophages approved to control Listeria on meat; toxigenic E. Coli next on the list.
A18 Genetic clues to cardiomyopathy and sudden death found in mice - emphasis on the right ventricle
A18 NEJM: Daptomycin as good as gent + vanc for Staph. aureus endocarditis
A16 Antibiotic skin infections becoming commonplace
A10 Mayo Clinic researchers come up with consensus for use of bisphosphonates in multiple myeloma.
J31 MMWR: New multidrug-resistant strain of HIV identified in New York
J06 Statins inhibit replication of hepatitis C virus
J05 Liver damage due to moderate doses of acetaminophen highlighted in JAMA paper
J03 Fish oil emulsion instead of Intralipid (soybean oil) for parenteral nutrition prevents/reverses liver damage.
J28 NEJM: Acetylcysteine protects against contrast nephropathy in angioplasty patients
J24 Does coffee protect against alcoholic cirrhosis?
J16 CARI (Australasian) Clinical Practice Guidelines published (53 free full text review papers!)
J14 Hyperglycemia in non-diabetic ICU patients predictive of mortality, esp. in cardiovascular disease
J08 Renal Solutions reincarnates a newer, better Redy cartridge system for home and ICU dialysis.
J06 Mayo clinic shows that thalidomide plus dexamethasone for multiple myeloma gives better results.
J06 FDG PET useful in detecting hard-to-detect chronic osteomyelitis
M30 It's the cooling of the blood in the extracorporeal circuit, stupid!
M17 Superbug slain by soil antibiotic
M13 E. Coli O157 recovered from bagged salad: cause diarrhea with ARF
A28 Does chamomile tea interact with warfarin?
M30 Strangers' prayers found to offer no benefit for recovery of heart bypass patients from surgery.
M24 MMWR: Fatal lead poisoning in a child from ingestion of a lead charm from a bracelet.
M08 NEJM: In multiple myeloma, thalidomide is of marginal additional benefit to melphalan/autologous stem cell transplant.
M06 Annals: Dramatic recent rise in community-acquired MRSA infections.
M03 FDA issues additional warning on Prisma system and problem of excessive fluid removal.
F24 FDA approves new antifungal drug (Eraxis) effective against serious Candida infections.
F06 Rapid new test could cut MRSA risk.
F06 Synthetic heparin could replace animal-derived drug.
J26 Aprotinin (Trasylol) linked to increased risk of kidney failure, heart attack and stroke.
J25 32% of Americans carry S. aureus in their noses, and 1% (2 million) carry MRSA.
J23 Annals: Liver failure and hepatitis from telithromycin.
J21 FDA announces new program to monitor safety of medical devices.
J19 Study of drug resistance among bacteria found in soil can potentially guide new drug development.
J18 Helicobacter pylori becoming drug resistant - sequential therapy may do a better job.
J15 Acetazolamide reduces sleep apnea severity in heart failure patients.
J15 Thiamin deficiency common in hospitalized heart failure patients
J09 U.S. FDA sends Gambro a warning over Prisma machines manufactured in Italy.
J07 CJASN: Diagnostic and Therapeutic Corner: HAART and the Kidney
J07 CJASN CPC (full text): A 42 year old man with oliguric renal failure.
J05 MRSA patterns in ICUs changing: 64% prevalence rate, hardier, bugs, but less multi-drug resistance.
D28 Saliva test for hepatitis C developed by Israeli scientists.
D27 Acute renal failure due to phosphate-based colonoscopy preps.
D27 Acetaminophen can cause acute liver failure when usual dose is even slightly exceeded.
D26 Need a used medical device? Try Ebay.
D26 MMWR: Outbreaks of E. coli O157:H7 associated with petting zoos.
D26 Dalbavancin (a vancomycin-like drug) effective in mice against anthrax.
D23 Aspergillus fumigatus genome sequenced.
D21 New study says that two million Americans are nasal carriers of MRSA.
D17 Heteropolymer antibodies - a new approach to treat and prevent? MRSA infections.
D16 Mitochondrial gene haplotype has marked effect on survival after infection.
D12 Oral endothelial receptor antagonist ambrisentan effective in pulmonary HTN.
D12 AMG531 (Amgen drug) increases platelet count in patients with ITP.
D06 Annals paper shows that plasma exchange does not help in ARF due to MM.
D05 Coffee intake may reduce risk of liver damage.
D03 New CPR device improves blood return to the heart.
D03 Random testing shows high lead levels in some imported Chinese plums.
D01 Coffee and tea associated with lower risk of chronic liver disease.
N30 Study of ICU ultrafiltration with CHF solutions device published in the JACC.
N29