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HDCN News Archive -- Diabetes
M06	PNAS: Erythropoietin promoter polymorphisms associated with diabetic retinopathy and progression to ESRD.
M05	ASN Renal Week abstract archives 2003-2006 now available on-line in .pdf format.
M05	FDA Study: Injuries and deaths linked to insulin pump use in teens.
M04	Study suggests that the number of fat cells is set for life at adolescence, without change during dieting or weight gain.
M04	Nature genetics: More obesity genes found
M01	Obesity linked to heart failure and inflammatory mediator elevation in observational study.
A30	Ranibizumab better than laser photocoagulation for diabetic macular edema.
A29	JCEM study shows that trifusal, a salicylate-like drug, increases insulin secretion in obese non-diabetics.
A29	Thiazolidinediones (glitazones) may increase fracture risk in diabetics.
A23	Some compounds in Chinese bitter melon identified with activity against diabetes.
A23	High adiponectin levels linked to kidney dysfunction and albuminuria.
A22	New nanoparticle-based hydrogel allows orally administered insulin to be absorbed.
A21	New book emphasizes potential harm of high-fructose sweeteners.
A15	Vitamin D supplementation effective in relieving neuropathic pain in type 2 diabetes.
A12	Alginate-coated pancreatic beta cells from fetal pigs transplanted into 4 diabetics with mixed results.
A09	JAMA RCT shows American Indian tye 2 diabetics with LDL lowered to 70 have lower carotid IMT and LV mass than those with LDL lowered to 100.
A04	BCG vaccine reverses type 1 diabetes in mice; now a clinical trial is underway.
M31	More good data about pioglitazone suggesting reduction of atherosclerosis.
M31	Six new genetic variants associated with type 2 diabetes.
M28	Normal weight (BMI) obesity linked to metabolic syndrome.
M27	Keryx ends development of sulodexide after negative trial results.
M26	Chinese folk remedy vegetable, bitter melon, contains compounds that activate AMPK, similar to metformin.
M20	Insulin affects lifespan of C. elegans via inhibition of SKN-1.
M17	Dynamis Therapeutics announces discovery of new class of RAGE inhibitors.
M16	Blood vessel protein Robo4 reverses diabetic and age-related macular degeneration in mouse model.
M14	MGH study will determine if BCG vaccination halts type 1 diabetes in humans as it does in mice.
M12	Vitamin D supplements given to children may cut risk of subsequent development of type 1 diabetes.
M12	Keryx diabetes drug sulodexide fails to achieve primary endpoint in phase III clinical trial.
M11	Eli Lilly follows Pfizer and NovoNordisk in discontinuing inhalable insulin.
M10	Low levels of PYY, a food-induced gut hormone, may be an early marker for type 2 diabetes.
M06	7th Annual Prevention in Renal Disease Conference, Toronto, Sept. 19-20, 2008.
M05	A mystery: why does gastric bypass improve type 2 diabetes even without weight loss?
M04	Activating PPAR-delta suppresses inflammation in vascular tissues.
M04	PPAR-gamma knockout mice show hypertension and severe vascular dysfunction.
M04	Retinopathy may begin at lower blood glucose levels than expected.
F27	Addition of alpha-1-antitrypsin to 3-drug cocktail cures type 1 diabetes in mouse model.
F26	Heart attack rates fall in France following institution of national smoking ban in public places.
F26	FDA: Medication guide must be given to patients with each rosiglitazone (Avandia) prescription.
F21	Insulin-secreting beta cells created from stem cells.
F20	HbA1c test falsely low in dialysis patients due to short RBC survival; glycated albumin better reflects glucose exposure.
F14	International study of tight glucose control shows no evidence of increased death risk - contradicts US study
F13	University of Groningen study (PREVEND) emphasizes utility of treating hypertension in proteiniuric patients.
F13	UK's National Health Service approves pancreatic islet cell transplants for type 1 DM.
F08	Poor hyperglycemia control downregulates expression of fat-burning gene (diacylglycerol kinase delta)
F07	Identical twins study shows that obesity and waist size is 77% due to genetic factors.
F06	More on the halted NHLBI diabetes trial arm. Role of rosiglitazone use in the intensive treatment arm unclear.
F06	NHBLI stops intensive glucose lowering treatment arm of study due to excessive deaths.
F05	Type 2 muscle fibers, such as those increased by body building, improve metabolic syndrome in an animal model.
J31	Sweetened soft drinks and fruit juices linked to increased risk of gout in men.
J30	Breast size linked to diabetes risk
J28	24-h glucose monitoring suggests that coffee (via caffeine) ingestion worsens glucose control
J28	Blood levels of organochlorine pesticides linked to type 2 diabetes.
J25	Stem cells found in the pancreas.
J23	Obesity surgery found to be more effective than diet in curing type 2 diabetes.
J11	Sorbitol in sugar-free foods and gum, when ingested in high amounts, may cause diarrhea and weight loss.
J11	Lancet meta-analysis suggests that all diabetics should be on statins.
J09	Cannabinoid receptor blocking drug effective in causing weight loss.
J01	Lack of deep sleep may increase type 2 diabetes risk.
D28	American Diabetes Association comes out in support of lower carbohydrate diets.
D27	Bayer recalls certain lots of blood glucose test strips due to overly high readings.
D25	Higher levels of HDL in diabetes may inhibit NO via myristic acid binding - outcome effects unknown.
D25	Prevalence of diabetes in Dubai reaches 25%.
D19	Northwestern University gets 700 M royalties for diabetes pain drug patent.
D14	January JASN paper reports that PROActive (pioglitazone) associated with lower CV mortality in diabetics.
D12	More heart risks identified for Avandia.
D11	Physicians unaware of guidelines to treat patients with CV risk factors and metabolic syndrome.
D04	Waistline growth on high-carb diets linked to liver gene.
D04	Renin-angiotensin linked to obesity and insulin-resistance in a gene knockout animal model.
D03	Rosiglitazone stimulates osteoclasts, which may account for associtation with increased fracture risk.
D03	Low carb diet more effective than low fat diet in reducing inflammatory markers in patients with metabolic syndrome.
N26	High-glycemic intake carb intake linked to type 2 diabetes in African American and Chinese women.
N14	FDA adds black box warning of heart attacks for Avandia (rosiglitazone)
N14	Diabetics risk serious foot problems by wearing the wrong size shoes.
N06	Lancet: Fenofibrate treatment lowers risk for laser treatment in diabetic retinopathy.
N06	Mouse model demonstrates that inflammation, and not obesity per se, causes insulin resistance.
N06	New feedback pathway from fat cells to the pancreas to increase insulin secretion identified.
O29	Maggots to treat diabetic foot ulcers infected with MRSA.
O25	Charcot foot disease becoming more common as diabetic numbers increase.
O23	Early results with implantation of pig pancreatic islet cells to treat diabetes are encouraging.
O23	Global extent of obesity epidemic in the news.
O23	Direct link to FDA Byetta (exenatide) pancreatitis alert
O23	Acute pancreatitis associated with exenatide (Byetta) - FDA requires labeling change
O22	Chewing gum shown to help curb appetite and reduce cravings.
O12	Is fructose really that bad?
O08	New antibiotic ceftobiprole very effective in curing diabetic foot infections.
O01	Monitoring methyl nitrate levels in exhaled air may replace blood glucose testing in type 1 diabetics.
S24	All previous vitamin E trials fatally flawed due to underdosing.
S21	Huge rise in number of mothers with gestational diabetes.
S20	Thiazide diuretics exacerbate fructose-induced metabolic syndrome.
S10	Blocking Formation Of Toxic Plaques Implicated In Type 2 Diabetes
A30	New mechanism of action of thiazolidinediones discovered.
A27	Obesity rates climb in most states.
A27	Tiny retinal implants may allow the blind to recognize objects.
A23	Very high levels of reactive carbonyl compounds found in high fructose corn syrup.
A23	High fat mass secreting adiponectin can protect against metabolic syndrome in genetically engineered mice.
A21	Gustducin - new sugar-sensing receptor identified in the intestine; activated by artificial sweeteners
A18	Low carbohydrate diets and metabolism: Atkins may not have been so far off, after all.
A17	New roles for sirtuin 2 identified in controlling fat cell metabolism.
A10	New research shows skeleton to be an endocrine organ via osteocalcin.
A08	Annals: New study questions the increased heart attack risk with Avandia; original NEJM meta-analysis claimed to have been flawed.
A07	Masked thiamine deficiency (problems with RBC transketolase assay) linked to diabetic vascular disease.
J31	FDA panel recommends continued sale of Avandia, despite some evidence of increased heart risk.
J30	FDA Advisory Panel to explore safety and risks of Avandia.
J25	Obesity spreads among friends, study concludes.
J24	Soft drinks, including diet soft drinks, linked to 50% higher risk of metabolic syndrome.
J21	New Cochrane analysis focuses on increased side effects in patients taking rosiglitazone (Avandia)
J19	Weight loss pill rimonabant associated with increased suicide risk.
J17	Eating a high glycemic index diet is associated with age-related macular degeneration.
J16	Gene discovered that increases risk for type 1 diabetes in children.
J16	Older, cheaper pills just fine to treat diabetes.
J12	Hydroxychloroquine (Plaquenil) may be protective against developing type 2 diabetes.
J12	Serum levels of retinol-binding programs indicate level of visceral fat.
J10	Selenium supplements appear to raise risk of developing diabetes in RCT.
J26	Higher fat mass associated with less coronary artery calcification in type 1 diabetics.
J19	Randomization complete for phase III trial of sulodexide for diabetic nephropathy.
J19	Intentionally skipping insulin doses to lose weight - diabulimia - has severe consequences.
J07	New compound similar to aMSH, causing satiety, may be effective in controlling weight in the obese.
M25	NEJM: Full text of meta-analysis that found an increased risk of myocardial infarction with rosiglitazone.
M24	Oxychlorine-containing water - new treatment for diabetic foot ulcer infections.
M14	Effect of polyphenols (from apples, onions, green tea) on fat catabolism.
M14	Study shows unsuspected immunomodulatory effects of glucosamine.
M03	Maggots rid diabetic foot ulcer patients of MRSA
M03	Honey paste to treat diabetic foot ulcers
A30	Activating PPAR-delta may burn fat and reduce metabolic syndrome risk.
A27	New Genetic Risk Factors For Type 2 Diabetes Identified
A24	AGEs and food preparation may play an important role in chronic disease.
A18	Animal study suggests that changing to a low-fat diet can induce stress.
A16	Thrifty gene hypothesis of diabetes causation under dispute - no ethnic linkage found.
A14	Fish pollutants possibly linked to type 2 diabetes.
A12	Rebuilt immune system helps patients shake off diabetes
A05	Think that eating only once a day will make you lose weight? Nope.
A05	Reperfusion with glucose responsible for brain damage after hypoglycemic coma.
M30	Microencapsulated pig islet cells surviving and producing insulin in one patient ten years after implantation.
M26	DPP-4 inhibitor Januvia (sitagliptin1) approved for treatment of type 2 DM in Europe
M16	Fructose linked to deranged liver metabolism in rats, involving PPARs, leptin, and metabolic syndrome.
M16	Phthalate exposure linked to metabolic syndrome
M05	New type 1 diabetes susceptibility gene discovered.
F21	Apolipoprotein C1 linked to obesity and type 2 diabetes in American Indians.
F12	Type 2 diabetes genes mapped out
F07	Pine bark extract shown to be a potent inhibitor of GI glucose absorption
J29	Carbonic anhydrase-I linked to blood vessel leakage in diabetic retinopathy
J17	New class of insulin sensitizing compounds discovered for treating diabetes.
J15	Pancreatic-polypeptide containing chewing gum - a new potential weapon against obesity
J09	Carnosinase 1gene linked to progression to kidney failure in diabetics.
D26	Study identifies liver glucose sensor involved in regulation of endogenous glucose production
D20	Friendly microbes could make you fat: Bacteroides vs. Firmicutes
D19	Australians develop modified sugar product with low glycemic index.
D16	FDA updates labeling for Trasylol (aprotinin) regarding risk of renal dysfunction, anaphylaxis, and re-exposure.
D15	New theory of type 1 diabetes: Pancreatic sensory nerve damage and substance P - and you can prevent it in animals!
D15	VEGF blocker ranibuzumab shows impressive results in diabetic macular edema.
D15	Cytohesins may play a key, previously unrecognized, role in diabetes.
D12	Diet resulting in 10% body weight loss leads to measurable loss in bone density over 1-year period.
D11	FDA proposes rules overhaul to expand access to experimental drugs.
D05	Type 2 diabetes mellitus increasing markedly in children.
D04	Rosiglitazone vs. metformin or glyburide study: Is the benefit worth the disadavantages?
D04	Focus on exercise rather than diet helps guard obese patients against further weight gain.
D04	Rosiglitazone more effective than metformin or glyburide as monotherapy for type 2 DM.
N30	Overfeeding of pets leading to obesity and diabetes.
N27	Gene linked to wet form of macular degeneration.
N26	HDCN: Search index updated for audiofiles, slide/audio talks, articles, and abstracts
N23	New data suggests spleen cells can reverse type 1 diabetes in mice.
N20	Gut parasites in dragonflies cause "metabolic syndrome".
N13	Pioglitazone reduces progression of atherosclerosis in diabetics
N10	Asia on brink of diabetes disaster, experts warn.
N10	New technique can block VEGF inside cells, with implications for retinal neovascularization, cancer.
N09	Exercise and cutting calories each lower risk of diabetes to a similar extent.
N08	ACE2 enzyme may hold key to treatment of diabetic kidney disease.
N08	Chloroquine may improve metabolic syndrome.
N07	Retinal MRI poised to advance diagnosis of many types of retinopathy
N07	Why do we eat mindlessly and what would induce us to stop?
N06	Children's belly fat increases by more than 65% since 1990.
O31	Device measures skin fluorescence to determine amount of accumulated AGE burden in diabetics.
O25	FDA expands alert on counterfeit glucose test strips
O23	Diabetes susceptibility gene has important impact on whether or not type 2 DM will develop.
O19	Risk-benefit advantages questioned for pioglitazone in Cochrane systematic literature review.
O17	FDA approves new treatment for diabetets - Januvia (sitagliptin)
O12	Get on scale daily to keep off lost pounds.
O12	Higher magnesium intake lowers type 2 diabetes risk in African American women
O04	Pine tree bark extract improves functional measures of diabetic microangiopathy.
O02	High magnesium diet (in people without kidney disease) linked to lower risk of diabetes
O02	Mild vitamin C deficiency inhibits fat oxidation during submaximal exercise; may contribute to obesity.
S28	NEJM: Islet cell transplantation paper
S28	Pancreatic islet cell transplant in diabetes works - sort of (NEJM paper)
S26	Generex develops metformin-containing chewing gum, oral insulin spray, as novel drug-release products.
S20	Does vitamin D protect the kidney against diabetes?
S19	Poor quality of sleep linked to poor glucose control in type 2 diabetics.
S17	Glutamic acid decarboxylase (GAD) vaccine may prevent type 1 diabetes
S14	MMWR documents rising tide of obesity in the United States.
S14	Australian team discovers structure of insulin receptor.
S14	Pioglitazone shows benefits in terms of cardiovascular outcomes.
S12	Pancreatic primordia cells from pigs reverse type 1 or type 2 diabetes in rats
S11	Want to fight fat? Eat brown seaweed!
S05	U. Colorado researches identify gene that markedly increases risk of type 1 diabetes
S04	Obesity pandemic is sweeping the world
A21	Some diabetologists changing views of lower-carb diets for type 2 diabetes control.
A18	Role of BMI as a measure of obesity and cardiovascular risk questioned.
A09	Chronically high blood sugar linked to risk of cognitive impairment
A03	Is saturated fat evil? Think again. CLAs in dairy act similar to PPAR agonists; may be of benefit in diabetes
J28	Medi-honey helps heal problem wounds
J03	Study suggests infectious cause of type 1 diabetes
J01	Netrins grow nerves in diabetic mice.
J20	Type 2 diabetes rate doubles in last 30 years.
J20	Molecular mechanisms of vaccine against type 1 diabetes is revealed.
J16	CARI (Australasian) Clinical Practice Guidelines published (53 free full text review papers!)
J14	Hyperglycemia in non-diabetic ICU patients predictive of mortality, esp. in cardiovascular disease
J14	Low carb diet improves glycemic control in diabetes (pdf)
J14	Low carb diet reverses progressive renal disease in diabetic (case report)
J14	Feeding monkeys a high trans-fat diet markedly adds to abdominal fat.
J14	Serum levels of retinol-binding-protein-4 reliably predict insulin resistance.
J12	Ruboxistaurin helps protect vision in diabetics with nonproliferative retinopathy
J08	GCN5 protein key to regulation of glucose release by liver cells.
J01	For PD patients with diabetes: It's the carbs, stu...
M15	Antiviral gene variant linked to type 1 diabetes - consistent with viral causation theory.
M09	New triglyceride lipase enzyme found; its regulation may be key to some types of obesity
M07	Study suggests that aspartame does not raise risk of cancer
M07	Gene affecting angiogenesis around pancreatic beta cells linked to type 2 diabetes
M03	Mayo: 20 g sodium, 50% saturated fat diet improves BP, lipids in obese.
A28	Magnesium deficiency and metabolic syndrome re-emphasized
A27	Consuming a high glycemic index diet increases risk of age-related macular degeneration.
A25	University of Michigan to pay for preventive diabetes meds for its employees.
A24	Drug combination reverses type 1 diabetes in an animal model.
A19	American Association of Clinical Endocrinologists Annual Meeting abstracts (.pdf)
A04	Pine nut oil or conjugated linoleic acid both significant appetite suppressors.
M28	Juvenile diabetes reversed in animal model using dendritic cell injections.
M28	High-fat diet induces type 2 diabetes changes in mice via glut-2
M26	Restricting carbohydrates to 20-30% of dietary intake normalized blood glucose in type 2 DM
M19	AGE in blood vessels activates angiotensin II via RAGE-induced chymase
M16	Glycemic index is bupkus.
M12	Chromium of no benefit in type 2 diabetics
M10	Tight glucose control results in 50% lower incidence of neuropathy 10 years later in juvenile diabetics.
M08	Diabetes drug Byetta (exenatide) gaining attention as weight loss aid.
M07	Serum marker of artery damage linked so small increases in the BMI or waist-hip ratio.
M07	ADA releases tools for optimal management of diabetes in the Latino population.
M02	Hyperglycemia and hypoglycemia associated with use of gatifloxacin.
F27	Marijuana compound may help stop diabetic retinopathy
F26	Childhood obesity time bomb explodes.
F21	Alginate-encapsulated pancreatic islet cell transplants for diabetes.
F19	Pig islet cell transplants reverse diabetes in monkeys.
F10	IU scientists using stem cells to treat severe peripheral arterial disease.
J30	Certain adenovirus infections linked to obesity on animals and humans
J28	FDA approves first ever inhaled insulin for the treatment of diabetes.
J21	British study shows that work stress linked to both heart disease and metabolic syndrome.
J16	Strong linkage between one particular gene and type 2 diabetes confirmed.
J16	Canadian study suggests higher mortality among diabetics treated with sulfonylurea drugs vs. metformin.
J09	Is Alzheimer's disease a new form of diabetes, limited to the brain? Brown Medical School researchers say so.
J06	Post-marketing data detects new onset / worsening of macular edema in patients taking Avandia (rosiglitazone).
J02	UCSF study in Annals suggests that obesity increases risk of kidney failure.
J02	U.S. weighs obesity surgery options
D30	Ten most important findings relating to diet, health and lifestyle for 2005: Year in Review
D26	Diabetes, CHF home patient monitors taking off in the UK.
D25	Strict regimen reduces diabetes risk
D07	Fructose may be cause of obesity epidemic; also raises uric acid.
N29	Why trying to make couch potatoes exercise may be difficult.
N29	Fatty liver being seen increasingly in obese patients.
N28	High-carb diet linked to diabetic hypertension.
N17	Oralyn, an oral insulin-like drug, to be launched this month in Ecuador.
N17	Tea, cinnamon, buckwheat, and cherries for diabetics.
N16	Pioglitazone reduces heart attack rate in type 2 diabetics by 28%.
N13	Is type 2 diabetes a mitochondrial deficiency syndrome?
N13	ASN: Sulodexide phase 2 trial shows good results in diabetic nephropathy.
N07	NASA develops Star Trek glasses for the visually impaired.
N07	Millions of U.S. adolescents on the road to diabetes.
N07	Chlamydia found in 50% of eyes with wet form of macular degeneration.
N07	Taste bud receptor for fat identified in rat tongue.
N06	New FDA-supported website lists latest approved drug labels for all meds.
N05	MMWR: Progression in diabetics stabilizing or slowing in recent years.
N01	Diabetic blacks have less coronary artery disease than diabetic whites.
O30	CDC report estimates 7% of US population has diabetes.
O28	FDA delays decision on approving inhalable insulin
O27	New endogenous carbohydrate (INS2) discovered that lowers blood glucose.
O26	ASN Renal Week 2005 abstracts now available on-line.
O23	JAMA: Increased mortality after bariatric surgery.
O23	JAMA: Article detailing CV risk increase with Pargluva (muraglitazar)
O21	FDA approvable status for diabetes drug Pargluva raises safety concerns.
O12	China ranked 2nd in world incidence of diabetes.
O12	JAMA: ESRD incidence, prognosis improving in diabetics.
O12	Vanadium supplements speed recovery from infections (in mice).
O09	JASN: Glycosylated Hb in non-diabetic CKD pts. increases mortality risk.
O07	Lancet: Pioglitazone lowers risk of heart attacks and strokes in diabetics.
O07	Pegaptanib shows promising results in treating exudative macular degeneration.
O04	90% of Framingham cohort over 60 years of age now overweight.
S26	Smoking appears to double the risk of developing type 2 diabetes.
S20	Type 2 diabetes prevalent in Canada; many complications and poor control.
S13	New IDF global guideline for type 2 diabetes.
S13	Pioglitzaone improves cardiovascular outcomes in diabetics.
S13	High blood sugar levels linked to heart disease, even in nondiabetics.
S11	FDA approves first glitizar-class drug for treatment of type 2 diabetes.
S09	FDA advisory panel recommends approval of inhaled insulin.
S09	Spironolactone added to ACEI/ARB gives added renoprotection in diabetics.
S09	Reduction of severe hypoglycemic episodes another benefit of islet cell tx.
S09	Liver TORC2 identified as key regulators of blood glucose levels.
S06	Soy protein-rich diet may help prevent fatty liver of diabetes.
A28	Bluetooth mobile phone link allows diabetics to monitor trends in their glucose.
A26	Klotho gene may increase longevity by causing insulin resistance.
A26	Metabolic syndrome doesn't exist, diabetes groups claim.
A26	Metabolic advantage of protein-rich diets may be due to leucine.
A24	NEJM: EPO associated with proliferative retinopathy in patients and mice.
A24	TFAH releases report on obesity in America - we're all getting fatter.
A19	Magnetic nanoparticle MRI used to visualize inflammed pancreas in type 1 DM.
A19