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HDCN News Archive -- Nephritis |
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| J30 |
Cancer cure strategy in mice to be tested in humans: transfusion of allogeneic cancer-killing leukocytes. |
| J28 |
FDA/Roche: Progressive multifocal leukoencephalopathy (PML) warnings added to mycophenolate labeling. |
| J25 |
Site indentified at which microRNAs may down-regulate immune response. |
| J18 |
Computer generated warfarin dosing as effective as dosing by expert prescribers. |
| J12 |
Sequential treatment of lupus in women with cyclophosphamide and mycophenolate preserves ovarian function. |
| J11 |
Lupus more severe, and nephritis more common, in patients with Southern European ancestry. |
| J09 |
Myeloma drug Velcade (bortezomib) shows promise in treating lupus in an animal model. |
| J05 |
FDA: More on the ongoing review of TNF-blockers and cancer risk. |
| J05 |
Alcohol ingestion cuts risk of rheumatoid arthritis by 50%. |
| J04 |
FDA reviewing reports of increased cancer risk associated with TNF- blocking drugs. |
| M19 |
A new discovery regarding pathogenesis of lupus - abnormal editing of genes. |
| M16 |
Heparin-coated thoracic drainage catheters being recalled because of OSCS contamination. |
| M15 |
University of New Hampshire group enhances the immunomodulatory effects of IVIG by modifying its sialic acid residues |
| M13 |
Texting kids to take their medicine may increase compliance. |
| M05 |
ASN Renal Week abstract archives 2003-2006 now available on-line in .pdf format. |
| A29 |
Rituxan fails as lupus treatment in controlled trial. |
| A29 |
Jund, a gene that regulates activity of macrophages, linked to kidney inflammation. |
| A24 |
GAO says that FDA lacks resources to inspect non-US drug suppliers; only 8% are being inspected now. |
| A12 |
Once yearly zoledronic acid increases lumbar spine density by 4% in glucocorticoid-induced osteoporosis patients; better than risedronate |
| A10 |
FDA communication regarding CellCept and Myfortic (mycophenolate) - ongoing safety review. |
| A10 |
FDA notice regarding investigation of mycophenolate mofetil regarding progressive multifocal leukoencephalopathy. |
| M31 |
Mysterious periodic fevers in children cured by tonsillectomy. |
| M19 |
New camera with multiple lenses will be able to take detailed 3-D photographs. |
| M12 |
New macrophage-related protein implicated in inflammatory disease. |
| M06 |
Lupus foundation sponsored webchat about lupus and kidney disease scheduled for Wednesday, March 14th. |
| F23 |
Making heparin is a dirty job |
| F12 |
Embryonic stem cells can be used to create fully functioning immune cells. |
| F11 |
Integrin receptor linked to HIV infection and replication in the gut. Is a treatment already available? |
| J21 |
Anti-TNF compounds as well as rituximab, disrupt lymph node germinal centers. |
| J20 |
NEJM: Association of Systemic Lupus Erythematosus with C8orf13-BLK and ITGAM-ITGAX |
| J20 |
Nature genetics: Abstract link for lupus consortium genome link study |
| J20 |
Nature genetics: International consortium identifies multiple genes linked to lupus in women. |
| J17 |
Scientists find new genetic mutation that halts development of lupus. |
| D21 |
Complement cascade blocker eculuzimab effective against myasthenia gravis in animal model. |
| D08 |
FDA launches new drug safety newsletter. Here is the first issue (rituximab) |
| D03 |
Pharma companies to develop IgA proteases as a potential treatment for IgA nephropathy. |
| D03 |
New lupus susceptibility gene discovered - OX40L |
| N28 |
American College of Rheumatology 2007 Annual Meeting - abstract search tool |
| N28 |
Valproic acid and mithramycin show activity against lupus in a mouse model. |
| N09 |
Valproic acid reduces proteinuria in a mouse model of lupus nephritis. |
| N07 |
New diagnostic test for TTP (thrombotic thrombocytopenic purpura) to be available via Ohio State University. |
| N07 |
Prazosin appears to block some glucocorticoid effects. |
| N05 |
Gene associated with rheumatoid arthritis identified on chromosome 6. |
| N02 |
NephroCor introduces enhanced urine analysis test (RenalVysion) for kidney disease |
| O26 |
Hidden value found in junk DNA |
| O09 |
Can we make a computational model of the immune system? One group is going to try. |
| S25 |
FDA Drug Safety Newsletter: Progressive multifocal leukoencephalopathy associated with rituximab. |
| S10 |
Aspreva and Roche decide not to pursue application to FDA for CellCept as induction treatment for lupus nephritis. |
| S06 |
International pathology conference solves shows high-detail microscopy slides on the web. |
| S06 |
Study identifies genetic risk factor (STAT4) for lupus and rheumatoid arthritis. |
| S05 |
Phospholipase C epsilon gene mutation affects podocytes, causes infantile nephrotic syndrome. |
| A06 |
JCI paper shows that cleavage of a protein called dynamin a key event in causing podocyte leakage of proteins. |
| J26 |
MMWR: Cryptosporidiosis outbreaks associated with recreational water use. |
| J23 |
Sialic acid may determine whether IgG antibodies are anti- or pro-inflammatory - link to autoimmune disease? |
| M11 |
Lupus cluster in people living above abandoned oilfield in New Mexico. |
| A10 |
FDA re-emphasizes Salmonella risks for people with impaired immune systems keeping pet turtles. |
| J22 |
New master gene that regulates autoimmunity and regulatory T cells identified. |
| D19 |
FDA warns about two cases of progressive multifocal leukoencephalopathy (PML) in lupus patients treated with rituximab. |
| D12 |
New EPO-like drug mimics action of thrombopoietin: designed to treat thrombocytopenia. |
| D11 |
FDA proposes rules overhaul to expand access to experimental drugs. |
| N26 |
HDCN: Search index updated for audiofiles, slide/audio talks, articles, and abstracts |
| N14 |
Lymphostat (belimumab) effective against lupus in paper presented at rheumatology meeting. |
| N07 |
Michigan researchers link gene mutation in phospholipase C epsilon to podocytes, infantile kidney failure. |
| O26 |
Phase 3 trial design for belimumab to treat SLE approved by FDA |
| S27 |
La Jolla Pharm announces addition of new sites, reactivation of Riquent (abetimus) study to treat lupus. |
| S26 |
Genetic variations in MHC (major histocompatibility locus) posted on-line, clues for transplant and immune diseases. |
| S14 |
Spleen may be target for successful therapy of lupus. |
| S06 |
Chronic sinusitis linked to immune response to parasites and chitinase enzyme levels |
| S04 |
Mutation affecting platelets gives clues about crescentic glomerulonephritis |
| A04 |
New research gives clues as to why IVIG works in autoimmune disease (sialic acid). |
| J19 |
New egg freezing technique may be of interest to patients undergoing cytotoxic therapy. |
| J16 |
CARI (Australasian) Clinical Practice Guidelines published (53 free full text review papers!) |
| J16 |
Precise gene defects identified that cause lupus in mice. |
| J16 |
Rats that don't shower every day may be protected against autoimmune disease. |
| M24 |
Canadian scientists working to develop a synthetic replacement for IVIG |
| A27 |
Stem cells replace or fix podocytes damages in animal model of Alport syndrome |
| F26 |
Mystery solved: Gold's power against autoimmune diseases defined |
| F21 |
Is there a way to avoid the bladder toxicity of cyclophosphamide? |
| F12 |
Anti-malarial drugs lower elevated TNF-alpha levels in lupus patients. |
| F01 |
Stem cell transplants offer hope against lupus. |
| J28 |
Enhanced oocyte cryopreservation method (of interest to GN patients requiring cytotoxic therapy). |
| J19 |
Commonly used antidepressants may also affect the immune system. |
| J11 |
Infection fighting protein (cryopyrin) may be key to auto-immune disease. |
| D06 |
Annals paper shows that plasma exchange does not help in ARF due to MM. |
| N23 |
US RCT shows mycophenolate better than cyclophosphamide to remit lupus nephritis |
| N17 |
Genetic profiling identifies 10 genes linked to severity of lupus. |
| N17 |
Canadian study suggests that drinking too much water can harm kidneys. |
| N16 |
Trichostatin may reduce premature atherosclerosis in lupus patients. |
| N16 |
High HDL level is pro-atherosclerotic in lupus patients. |
| N08 |
Protein discovered that is key to survival of E. coli O157:H7 |
| N07 |
Are epigenetic changes in histones the key to lupus autoimmunity? |
| N07 |
Parasitic worms may hold key to immunosuppression. |
| O26 |
ASN Renal Week 2005 abstracts now available on-line. |
| O17 |
Smoking ups risk of thrombosis in lupus patients. |
| O16 |
Novel DnaJP1 rheumatoid arthritis drug works without being immunosuppressive. |
| O12 |
CD19 monoclonal antibodies suppress B cells better than rituximab. |
| O12 |
New immunosuppression strategy has little weight, and in fact is in outer space. |
| O09 |
SEPS 1 gene on chromosome 15 plays key role in inflammation. |
| O07 |
Study of tonsillar lymph cells highlights role of autoreactive B cells in lupus. |
| O05 |
Human Genome's experimental lupus drug Lymphostat-B fails to meet goals. |
| O03 |
THi cells make IL-17 and may be key to some autoimmune diseases. |
| S27 |
Baxter announces new IVIG (intravenous immune globulin) product. |
| S21 |
O-GlcNac sugars, rather than cyclins, prime determinants of cell cycle control. |
| J10 |
Gene for immune deficiency syndromes found. |
| J08 |
Genomic mechanism of increased azathioprine toxicity identified. |
| J04 |
How cells with damaged DNA alert the immune system |
| J10 |
Researchers get first peek at amyoid structure. |
| J07 |
New methods may preserve fertility in girls receiving cytotoxic therapy. |
| J06 |
Fibrillex retards CKD progression in AA amyloidosis. |
| M30 |
Workplace solvent TCE linked to immune system disorders. |
| M30 |
Freezing eggs before chemotherapy in women to preserve fertility. |
| M28 |
Long-term effects of Canadian toxigenic E. Coli outbreak in the news. |
| M07 |
Immune gene with 20% prevalence linked to CAD, rheumatism, and MS. |
| M06 |
Nephrogenex licenses kidney disease molecular profiling technology. |
| M06 |
Novel cation transport gene linked to inherited form of FSGS. |
| M03 |
Schelling paper that is the basis for the dipstick protein-SC calculator |
| M01 |
Lupus in Native Americans from New Mexico often involves the kidneys. |
| A16 |
Lupus Research Institute launches awareness campaign with actor James Garner. |
| A09 |
CD36 may be a key component of innate immunity |
| A07 |
Lupus linked to Epstein-Barr virus IgA antibodies in Blacks. |
| M14 |
La Jolla lupus drug on track, but off the fast track in terms of FDA approval. |
| M02 |
Lupus Research Institute funds innovative research - get grant application. |
| F02 |
Lupus Research Institute increases funding for innovative research. |
| D02 |
Eating red meat associated with increased risk of rheumatoid arthritis. |
| N20 |
Another lupus drug in the pipeline - favorable animal studies |
| N11 |
Curagen working on monoclonal antibody treatment for IGAN |
| N07 |
North Carolina E. Coli outbreak grows, linked to State Fair, petting zoo |
| N05 |
Scientists identify new biomarkers for lupus |
| O30 |
ASN: Riquent lowers dsDNA levels in lupus patients as adjuvant therapy |
| O18 |
Mycophenolate effective to treat non-renal lupus |
| O18 |
Experimental lupus drug may also work against atherosclerosis |
| O15 |
La Jolla Pharma's FDA approval for lupus drug delayed: another RCT required |
| S24 |
Woman gives birth: Ovarian tissue frozen 7 years, reimplanted after chemoRx |
| S17 |
Urinary MCP-1 to follow the course of renal vasculitis |
| S16 |
Rituximab shows promise against lupus |
| S09 |
Prasterone (DHEA) effective as adjunctive Rx for lupus in RCT |
| S08 |
Cancer drug may reduce kidney disease in lupus |
| A29 |
A20 anti-inflammatory enzyme may prove to be a potent drug target |
| A26 |
NEJM: Bones OK in kids after steroid treatment of nephrotic syndrome |
| A23 |
IGF-1 receptor activation implicated in rheumatoid arthritis and autoimmunity |
| A18 |
Gene associated with lupus identified |
| A17 |
Group A streptococcus vaccine promising in early trials |
| A09 |
MMWR: Tuberculosis associated with TNF-alpha blocking drugs |
| J09 |
Lack of immune system protein prevents lupus-like condition in mice |
| J24 |
NEJM: Kidney disease no longer a killer for children |
| M15 |
NIH launches stem cell transplantation for lupus clinical trial |
| A06 |
Alliance for lupus research announces 6.7 M grant recipients |
| M03 |
Use of CYC + MMF or AZA for lupus published in
NEJM |
| F24 |
Isotope studies quantify water intake in normal people - averages 2.5-3.0 L/day |
| F23 |
c-maf oncogene elevated in half of multiple myeloma cases |
| F21 |
CellCept for lupus in the news |
| J27 |
Cystic fibrosis protein CFTR shown to have adenylate kinase activity |
| J22 |
First int. symposium on albuminuria (NKF-ISN) to be held in New York in May 2004 |
| J08 |
Anti-eosinophil therapy shown effective in treating hypereosinophilic syndrome |
| D16 |
La Jolla Pharmaceutical submits new drug application for anti-lupus compound |
| D10 |
Press reporting on MMF lupus study results from SUNY |
| D04 |
Multiple myeloma causing progenitor stem cell identified |
| D03 |
E. Coli O157 apparently spread by sawdust from exhibition hall rafters |
| D02 |
Revimid, a thalidomide derivative, may benefit multiple myeloma patients (PDF) |
| N11 |
Apoptosis of endothelial cells linked to heart risk in lupus patients |
| N01 |
Sulfatides (present on blood cells) are target for antiphospholipid antibodies |
| O28 |
TNF alpha linked to photosensitivity in lupus |
| O25 |
Mycophenolate trial results for lupus reported at Am Coll Rheumatology meeting |
| O22 |
Living with lupus: one patient's story |
| O22 |
Lactobacillus - vaccine combination lowers toxigenic E. Coli prevalence in cows |
| O15 |
NEJM: Autoantibodies in soldiers years before clinical onset of lupus |
| O06 |
NJ basketball star with FSGS on the rebound |
| S18 |
Cranberry juice may increase bleeding risk with warfarin |
| S08 |
Genetic approaches seek to eliminate O157 E. Coli gut colonization of cattle |
| S08 |
Vaccine against autoimmune disease to be tested |
| A25 |
Lupus Foundation of America to launch new patient-oriented magazine |
| A23 |
Lactoferrin spray on meat considered safe to fight E. Coli |
| A17 |
Philly petting zoo closed temporarily: possible source for toxigenic E. Coli |
| J29 |
O157:H7 antibody trial for HUS underway in Canada |
| J18 |
PPAR-alpha linked to steroid-induced diabetes and hypertension |
| J05 |
Argentina shuts McDonald, Burger King restaurants because of E. Coli fears |
| J04 |
Toxigenic E.Coli infected teens attending prom at Mississauga, Ontario |
| J03 |
ECSYSVAS: Cyclophosphamide can be replaced with azathioprine after remission |
| J25 |
NEJM: Bortezomib benefits a third of multiple myeloma patients |
| J14 |
How antibiotic therapy can worsen or cause HUS |
| J04 |
Hemolytic uremic syndrome tragic patient stories in the news |
| J02 |
Gene defect produces lupus-like disorder |
| M24 |
Phage transfer implicated in toxin-producing bacterial infections |
| M13 |
FDA approves proteasome inhibitor drug Velcade for multiple myeloma |
| M06 |
Staph aureus effect on B cells might be useful to treat lupus |
| A25 |
Bacteriophage approach can kill E. Coli, possibly also O157:H7 |
| A12 |
Should we routinely text the urine for microhematuria? |
| A11 |
Athlete sues NSAID maker, claiming NSAIDs cause his proteinuria |
| M24 |
High-dose steroids linked to cardiovascular disease |
| M11 |
Fish oil may benefit lupus patients |
| F18 |
La Jolla Pharmaceutical lupus drug (Riquent) fails key test; stock plummets |
| F15 |
Trichostatin ameliorates lupus expression in mice |
| F12 |
Interferon genes linked to lupus in NIH study |
| F10 |
RNA interference halts hepatitis in mice |
| F10 |
RNA interference halts hepatitis in mice |
| J22 |
Rapamycin may be useful against lupus |
| J18 |
Amgen says Enbrel works against psoriasis in study |
| J14 |
Abbott enters TNF blocker fray with Humira |
| J10 |
High-dose cyclophosphamide regimen for lupus patients |
| N07 |
View abstracts from Am Coll Rheumatol Annual Meeting |