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Emmett Radhakrishnan
Nephrology Quiz and Questionnaire: Fluid and Electrolyte and Glomerulonephritis Cases
Michael Emmett, MD, and Jai Radhakrishnan, MD
(ASN Renal Week Clinical Nephrology Conference, November, 2007.) Emmett: Case 2: Was it laxative that the patient drank? The wife said it was magnesium citrate. Anyway, now he's comatose with normal electrolytes. Then his creatinine goes up and his serum osmolality does, also, with positive ketones, but no acidosis. How would you treat him? Case 6: A woman who takes Topamax for migraines presents with hyponatremia and hyperchloremic acidosis. How does topiramate affect the kidney and what indications is it being used for? Radhakrishnan: Case 4: Young AA woman with nephrotic syndrome and elevated ANA. OK, it's membranous: lupus or not? If lupus, how do we treat it? Case 8: Middle-aged female with acute fulminant GN picture and a creatinine of 10. Is it worth treating her? What if she has anti-GBM? What if she has MPO-ANCA? .
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Palmer
Verbalis
Novel Therapeutics for Fluid and Electrolyte Disorders
Joseph G. Verbalis, MD, and Biff F. Palmer, MD
(ASN Renal Week Clinical Nephrology Conference, November, 2007.) Verbalis: What are the potential benefits of the vaptans in the treatment of SIADH? What are the proven advantages? Unproven advantages? Are there nonresponders to vaptans? If so, by what mechanism? Should vaptans be used in the treatment of acute hyponatremia? What are the potential lesser known adverse effects of hyponatremia in terms of cognitive function? Falls? Bone density? Palmer: How common is hyponatremia? What are the risk factors? How effective are the vaptans? What were the results of SALT1 and SALT2? How expensive is treatment with conivaptan? How might these high costs be justified in a hospital setting? Why does hyponatremia after vaptan treatment sometimes persist after vaptans are discontinued? What is one genetic basis of resistance to vaptans?
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Fluid, electrolyte and acid-base disorders associated with antibiotic therapy
Nat Rev Nephrol (Apr 2009)
Citrate- vs. acetate-based dialysate in bicarbonate haemodialysis: consequences on haemodynamics, coagulation, acid-base status, and electrolytes (Gabutti et al) BMC Nephrol (March 2009)
Dr. Chris O'Callaghan,
M.D.
BA, BM, BCh, MA, MRCP (UK), DPhil
Medical Research Council Clinician Scientist
Institute of Molecular Medicine and, Nuffield Department of Clinical Medicine
University of Oxford, John Radcliffe Hospital, Oxford, UK
Try Dr. O'Callaghan's 
