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HDCN News Archive -- Nephritis
May29 Three days of fasting every 10 days improve autoimmune diseases (in mice).
Dec14 Even more news on the new HDCN Facebook page!
Nov30 Multinucleated giant cells and amyloidosis
Nov22 Renal pathologists soon will be replaced by pigeons.
Nov21 Orphan drug designation may lead to high drug prices, like for rituximab.
May30 Vagal nerve stimulation lowers inflammatory response in rheumatoid arthritis
May27 Binding site for PLA2R antibodies identified and blocking molecules synthesized
Nov18 Abatacept slows or halts proteinuria in FSGS.
Sep18 Vaccinating cattle against toxigenic E. Coli could cut risk of infection in humans.
Apr05 Malic acid mouth spay for xerostomia.
Mar07 High salt diet linked to activation of Th-17 helper cells and multiple sclerosis in mice.
Dec10 Reprogrammed T-cells using an attenuated strain of HIV result in remission of acute lymphoblastic leukemia.
Nov19 Nanotechnology cures multiple sclerosis in mice; are other autoimmune diseases next?
Nov05 Eculizumab for atypical HUS shows promise on longer term treatment.
Oct19 Egg freezing works to preserve fertility.
Oct17 Vitamin D supplements may benefit lupus patients
Oct05 Eggs made from skin cells fertilized with male mouse sperm and give rise to seemingly normal mice.
Sep19 What's causing an epidemic of tubulointerstitial nephritis in Uddanam, India?
Sep07 Anti-PLA2R antibodies detected in 70% of patients with idiopathic membranous GN
Jul21 JASN early release: Rituximab shows good results in membranous nephropathy.
Jul05 Origin of follicular dendritic cells found.
May29 KDIGO publishes 2012 practice guidelines for treating glomerulonephritis.
May22 Abacavir side effects linked to autoimmune reaction.
May19 Mouse study suggests benefits of scheduled eating.
May10 More severe scleroderma in African Americans linked to certain antibodies.
May04 Two types of macrophage cell lines identified.
May04 American College of Rheumatology issues lupus nephritis guidelines.
May04 Cardiovascular risks of varenicline not confirmed.
Apr17 Caffeine use may help dry eye syndrome.
Mar13 Shiga-toxin E. Coli carrier state markedly reduced by azithromycin treatment.
Mar13 Shiga-toxin producing E. Coli associated with correctional facility-run dairy.
Mar08 Donor stem cell transfusion helps achieve tolerance in the recipient.
Mar08 Silver mouthwash to treat oral Candidiasis.
Mar08 Scientist make revolutionary progress in electron microscope resolution.
Feb26 How vitamin D inhibits inflammation
Feb14 Amino acid response pathway, autoimmune disease, tolerance, and a Chinese herb.
Feb14 CYBORD multiple chemotherapy regimen (using bortezomib) good for AL amyoidosis.
Jan13 NIH study shows that 32 million Americans harbor autoantibodies.
Dec20 Eculizumab for toxigenic E. Coli- related illness.
Dec20 Cryptochromes interact with glucocorticoids to regulate metabolic processes.
Dec13 B-cells that are active only in the gut, turning into monocyte-like cells there.
Dec13 Sugarcane nephropathy afflicts many, but cause remains a mystery.
Nov09 Most women with lupus can have successful pregnancy outcomes
Oct14 ASN Renal Week 2011 abstracts now available.
Oct04 Scrub your potatoes and leeks to reduce the risk of toxigenic E. Coli.
Oct04 Vitamin D deficiency common in patients taking oral steroids.
Oct04 Gut protein alphavbeta6 may be key to developing immune tolerance
Sep27 Eculizumab approved by FDA to treat atypical hemolytic uremic syndrome.
Sep21 Continued immunosuppressant treatment of lupus in ESRD may boost survival.
Sep13 Fish oil reduces the effectiveness of chemotherapy.
Jul25 New relationships between germinal centers and regulatory T cells identified.
Jul23 Early intravenous fluid therapy may reduce risk of kidney damage after toxigenic E. coli infection.
Jun28 New genetic risk factors for lupus found in African Americans.
Jun07 Number of non O157 E. Coli cases causing HUS rising in the United States.
May31 Swedish gene analysis shows that venous thromboembolism has a hereditary component.
May31 NEJM: Eculizumab of benefit in children suffering from hemolytic uremic syndrome due to toxigenic E. Coli.
May10 Lund University researchers develop new test to diagnose lupus.
Apr28 Leprosy in the United States via transmission from armadillos.
Apr19 TH17 blocking drug halts multiple sclerosis in animal models, may also affect lupus.
Feb16 NEJM: HLA allele linked to idiopathic membranous nephropathy..
Feb04 Defect in CD8 regulatory T cells linked to lupus in a mouse model.
Jan27 Could the predilection for autoimmune diseases among women be due to avoidance of dirt?
Jan15 National Library of Medicine's Daily Med website for quick access to drug package inserts.
Dec13 Lenalidomide boosts immunity in the elderly.
Nov16 FDA panel recommends approval of Benlysta to treat lupus flares.
Nov04 A traitor in our midst - the FAP-expressing immune cell protects cancer cells, allowing them to grow.
Oct18 Intestinal alkaline phosphatase (IAP) enzyme needed to maintain healthy bacteria in the gut.
Sep28 Abatacept found to be ineffective for lupus
Sep25 Octagam IVIG withdrawn from sale due to thromboembolic event risk.
Sep03 Mutation in toll-like receptor gene heightens lupus risk in men.
Aug29 Molecule found that deactivates selective components of the complement system.
Jul28 Presence of nonhuman sialic acid in biotech drugs can provoke an immune response.
Jul28 Pulse steroids kill plasmacytoid dendritic cells in lupus
Jul16 APOL1 gene increases risk of kidney disease in African Americans.
Jul15 NEJM: Rituximab may be better than cyclophosphamide for relapsing vasculitis
Jul15 NEJM: Rituximab similar to cyclophosphamide for treament of vasculitis.
Jul08 New mystery gene linked to FSGS
Jun17 Angiomyeloproliferative lesions in the kidney after direct autologous stem cell injection.
Jun17 Gut bacteria can clearly trigger arthritis in a susceptible-mouse model.
Jun10 Meta-analysis quantifies risk of nephrotic syndrome due to bevacizumab (2%).
Jun05 Baxter's IVIG Gammagard being withdrawn as a precaution due to allergic reactions.
Jun02 Activated basophils and IgE antibodies implicated in an animal model of lupus.
May04 Impaired function of natural killer T cells may contribute to pathogenesis of lupus and other autoimmune diseases
Apr30 Doxycyclin plus rifampin effective in Reiter's syndrome
Apr30 New gene link to scleroderma found
Apr28 Depomedrol and ACTH have different effects on osteonecrosis of the hip, VEGF.
Apr13 ITAM-coupled receptors linked to macrophage immune function, arthritis
Apr11 Nanovaccine stops type 1 diabetes from developing in mice.
Mar22 Effect of UV sunlight rays on multiple sclerosis -- something other than vitamin D at work?
Mar10 Hemolysis with intravenous immunoglobulin solutions
Jan29 Spontaneous remission in 34% of patient with idiopathic membranous GN treated conservatively.
Dec23 INF2 gene mutations linked to focal segmental glomerulosclerosis (FSGS)
Dec11 Blood stem cell transplants "cure" sickle cell disease in 9/10 adults
Dec04 Amyloid fibrils are toxic per se, the shorter the fibril, the more damage it causes.
Dec04 Observational study suggests remarkable protection against graft-versus-host disease by statins.
Dec03 Novel "locked nucleic acid" drug markedly lowers hepatitis C viral counts in chimpanzees.
Dec01 Are peptoids that disable autoreactive T cells the next step in treatment of autoimmune disease?
Nov26 Rituximab helps preserve beta cell function in patients with early type 1 diabetes.
Nov19 Cigarette smoke found to be contaminated with many pathogenic bacteria.
Nov06 1930s gonorrhea drug acriflavine blocks HIF-1 induced new blood vessel proliferation.
Nov05 Benlysta (belimumab) phase III trial for lupus gives positive results.
Oct29 Teriparatide outperforms alendronate in treating steroid-induced osteoporosis.
Oct28 Fish oil (DHA) metabolite resolvin 2 found to have marked anti-inflammatory activity
Oct28 Gut bacteria linked to diet, immune system functioning via short chain fatty acid receptor
Oct26 Histone released from damaged cells during trauma or sepsis damages blood vessels.
Oct23 FDA Medwatch reports another case of PML after rituximab in a rheumatoid arthritis patient.
Oct20 American College of Rheumatology 2009 annual meeting abstract search
Oct19 RItuximab as effective as cyclophosphamide in treating severe ANCA vasculitis.
Oct19 Gleevec for scleroderma
Oct19 Is lupus a garbage-disposal problem? And is PPAR delta an answer?
Oct15 Certain specific gut microorganisms induce the formation of Th17 immune helper T cells.
Sep24 AJKD issues containing KDOQI guidelines now freely available as .pdf files
Sep23 University of Michigan gets 10 million dollar grant to study nephrotic syndrome.
Sep14 Take a shower and get a faceful of Mycobacterium avium.
Aug28 Monoclonal gammopathy of undetermined significance found to be of undetermined significance.
Aug19 Vitamin D regulation of immune function via cathelicidin conserved in all primates.
Aug11 GIFT15 treatment modified B lymphocytes and reverses multiple sclerosis in the lab; may have potential in lupus as well.
Jul31 FDA warns of colchicine side effects when co-prescribed with clarithromycin and other drugs.
Jul31 Resveratrol found to have potent anti-infammatory effects.
Jul19 HGS/Glaxo drug Benlysta shows some effectiveness against lupus in phase 3 clinical trial.
Jul15 Bisphosphonates may lower mortality rate by an effect on the immune system.
Jul09 NOD2 receptor mutations impair ability to detect mycobacteria and are linked to Crohn's disease.
Jul02 NEJM: Phospholipase A2 receptor is a target antigen in 70% of patients with idiopathic membranous nephropathy.
Jun30 Key culprits in lupus (toll-like receptors) identified in mouse study.
Jun04 Halofuginone, Th17 cells, and autoimmunity.
May29 FDA: Serious fungal infections associated with TNF-alpha blockers.
May25 Search all abstracts from the World Congress of Nephrology 2009
May22 New anti-inflammatory drug candidate works by releasing hydrogen sulfide gas.
Apr27 Potential importance of vitamin D receptor, commensal bacteria, and olmesartan in autoimmune disease.
Apr27 CXCR4 overproduction, kallikreins linked to lupus nephritis in 2 separate studies.
Apr22 Proton-pump inhibitors and NSAIDS have synergistic anti-inflammatory effects, and ? neuroprotective properties.
Apr18 Ultrashort-acting prednisolone derivatives (antedrugs) stop inflammation and then are metabolized to avoid side effects.
Apr16 JASN: Mycophenolate and cyclophosphamide similarly effective as induction therapy for lupus nephritis.
Apr11 One thousand 2007-2009 audiofiles and slide/audio talks added to HDCN's 20 topic-related channels.
A09 A contrarian view proposes that excessive 25-D supplementation might exacerbate autoimmune disease.
M30 New lupus susceptibility gene (IRAK1) on the X-chromosome may explain increased risk of lupus in women.
M29 Link to slide/audio and audio symposia on HDCN
M24 Licorice can block absorption of cyclosporin
M19 Small but randomized lupus trial suggests that both cyclophosphamide and cyclosporine are useful additions to prednisone.
M11 Rituximab study as adjunct to MMF in lupus nephritis shows disappointing results.
F27 FDA warns of tardive dyskinesia risk with Reglan (metoclopramide)
F15 FDA now requiring that each patient receiving CellCept (mycophenolate) receive a patient education guide.
F02 Leprosy drug clofazimine holds promise as an immunomodulatory agent.
J21 Interleukin-21 linked to lupus in an animal model.
J09 New drug combo (Mozobil, VEGF, GCSF) induces the body to release new types of autologous "healing?" stem cells into the blood.
J07 New Bartonella species that infects humans (muscle fatigue, weakness, pericarditis) discovered.
D27 Proteosome inhibitor and multiple myeloma drug bortezomib effective in reversing acute transplant rejection in a pilot study.
D22 Two percent of circulating B cells in normal subjects potentially have autoimmune activity but are shut off.
D11 CJASN: Rosiglitazone may benefit patient with FSGS
D04 HALT-C trial shows absolutely no impact of interferon on progression of hepatitis C
D03 Scientists film inner workings of the immune system sing multiphoton microscopy.
N27 JASN early release: Imatinib suppresses cryoglobulin production in mice.
N04 NK-22 cells - they're in the gut, they make IL-22, and are involved in mucosal immunity.
N04 1-alpha-25OH-D hydroxylase active in the lung; may be involved in immune defense.
N04 Strange, complex pharmacokinetics of methotrexate in RBCs have implications for clinical treatment.
O29 Patients with lupus being treated with hydroxychloroquine may have lower rate of kidney damage in observational study.
O23 European watchdog agency suggests not using diet drug rimonabant due to depression side effects.
O22 Low-levels of gut bacteria that secrete anti-inflammatory compounds may underlie or worsen Crohn's disease.
O17 New Mycobacterium species identified that can cause bone infections in the immunocompromised.
O07 NRAA: Advance copy of ESRD program interpretive guidelines. (pdf)
O07 Gut bacteria may protect mice against type 1 diabetes, other autoimmune disorders.
O03 DNA of commensal, good bacteria augment the intestinal response to infection.
S19 African American women have low white blood cell count.
S15 MYH9 gene variants linked to FSGS and diabetic kidney disease in African Americans.
S11 Rituximab prescribing info revised to reflect risk of progressive multifocal leukoencephalopathy.
S10 Molecular mechanism of steroid-induced fatty liver determined.
S05 FDA warns about invasive fungal lung infections in patients taking TNF-alpha blockers.
A25 Longer-term low-dose IL-2 treatment (metronomic dosing) has fewer side effects when used for prostate cancer.
A25 New guidelines to treat rheumatoid arthritis focus on disease-modifying drugs.
A25 FDA approves Nplate (romiplostim) to stimulate bone marrow in thrombocytopenia.
A24 Bifidobacterium infantis may have systemic immune system benefits.
A20 Individual genome analysis shows that drug sensitivity may be poorly predicted by skin color (presumed race)
A13 T-cell furin linked to autoimmunity
A06 NephCure announces recipients of research awards focusing on FSGS.
A06 November CJASN paper details benefits of rituximab in treating membranous nephropathy.
J30 Bifidobacterium infantis continues to show promise as treatment for irritable bowel syndrome.
J27 Human autoantibodies from women with pre-eclampsia induce the condition in pregnant mice.
J24 Complement activation is increased in patients with age-related macular degeneration.
J23 Scientists isolate compound in saliva that speeds wound healing.
J17 Peptidoglycans from gut bacteria may induce C. albicans to transform into infectious variant.
J16 Has the Achilles heel of the HIV virus been located?
J11 FDA lists May 2008 labeling changes: Aranesp (tumor progression) and CellCept (lymphoma and PML risk)
J10 Computational biology approach leads to better understanding of immune response to presented antigen.
J08 Farm-raised tilapia fish has relatively low levels of omega-3 fatty acids.
J30 Cancer cure strategy in mice to be tested in humans: transfusion of allogeneic cancer-killing leukocytes.
J28 FDA/Roche: Progressive multifocal leukoencephalopathy (PML) warnings added to mycophenolate labeling.
J25 Site indentified at which microRNAs may down-regulate immune response.
J18 Computer generated warfarin dosing as effective as dosing by expert prescribers.
J12 Sequential treatment of lupus in women with cyclophosphamide and mycophenolate preserves ovarian function.
J11 Lupus more severe, and nephritis more common, in patients with Southern European ancestry.
J09 Myeloma drug Velcade (bortezomib) shows promise in treating lupus in an animal model.
J05 FDA: More on the ongoing review of TNF-blockers and cancer risk.
J05 Alcohol ingestion cuts risk of rheumatoid arthritis by 50%.
J04 FDA reviewing reports of increased cancer risk associated with TNF- blocking drugs.
M19 A new discovery regarding pathogenesis of lupus - abnormal editing of genes.
M16 Heparin-coated thoracic drainage catheters being recalled because of OSCS contamination.
M15 University of New Hampshire group enhances the immunomodulatory effects of IVIG by modifying its sialic acid residues
M13 Texting kids to take their medicine may increase compliance.
M05 ASN Renal Week abstract archives 2003-2006 now available on-line in .pdf format.
A29 Rituxan fails as lupus treatment in controlled trial.
A29 Jund, a gene that regulates activity of macrophages, linked to kidney inflammation.
A24 GAO says that FDA lacks resources to inspect non-US drug suppliers; only 8% are being inspected now.
A12 Once yearly zoledronic acid increases lumbar spine density by 4% in glucocorticoid-induced osteoporosis patients; better than risedronate
A10 FDA communication regarding CellCept and Myfortic (mycophenolate) - ongoing safety review.
A10 FDA notice regarding investigation of mycophenolate mofetil regarding progressive multifocal leukoencephalopathy.
M31 Mysterious periodic fevers in children cured by tonsillectomy.
M19 New camera with multiple lenses will be able to take detailed 3-D photographs.
M12 New macrophage-related protein implicated in inflammatory disease.
M06 Lupus foundation sponsored webchat about lupus and kidney disease scheduled for Wednesday, March 14th.
F23 Making heparin is a dirty job
F12 Embryonic stem cells can be used to create fully functioning immune cells.
F11 Integrin receptor linked to HIV infection and replication in the gut. Is a treatment already available?
J21 Anti-TNF compounds as well as rituximab, disrupt lymph node germinal centers.
J20 NEJM: Association of Systemic Lupus Erythematosus with C8orf13-BLK and ITGAM-ITGAX
J20 Nature genetics: Abstract link for lupus consortium genome link study
J20 Nature genetics: International consortium identifies multiple genes linked to lupus in women.
J17 Scientists find new genetic mutation that halts development of lupus.
D21 Complement cascade blocker eculuzimab effective against myasthenia gravis in animal model.
D08 FDA launches new drug safety newsletter. Here is the first issue (rituximab)
D03 Pharma companies to develop IgA proteases as a potential treatment for IgA nephropathy.
D03 New lupus susceptibility gene discovered - OX40L
N28 American College of Rheumatology 2007 Annual Meeting - abstract search tool
N28 Valproic acid and mithramycin show activity against lupus in a mouse model.
N09 Valproic acid reduces proteinuria in a mouse model of lupus nephritis.
N07 New diagnostic test for TTP (thrombotic thrombocytopenic purpura) to be available via Ohio State University.
N07 Prazosin appears to block some glucocorticoid effects.
N05 Gene associated with rheumatoid arthritis identified on chromosome 6.
N02 NephroCor introduces enhanced urine analysis test (RenalVysion) for kidney disease
O26 Hidden value found in junk DNA
O09 Can we make a computational model of the immune system? One group is going to try.
S25 FDA Drug Safety Newsletter: Progressive multifocal leukoencephalopathy associated with rituximab.
S10 Aspreva and Roche decide not to pursue application to FDA for CellCept as induction treatment for lupus nephritis.
S06 International pathology conference solves shows high-detail microscopy slides on the web.
S06 Study identifies genetic risk factor (STAT4) for lupus and rheumatoid arthritis.
S05 Phospholipase C epsilon gene mutation affects podocytes, causes infantile nephrotic syndrome.
A06 JCI paper shows that cleavage of a protein called dynamin a key event in causing podocyte leakage of proteins.
J26 MMWR: Cryptosporidiosis outbreaks associated with recreational water use.
J23 Sialic acid may determine whether IgG antibodies are anti- or pro-inflammatory - link to autoimmune disease?
M11 Lupus cluster in people living above abandoned oilfield in New Mexico.
A10 FDA re-emphasizes Salmonella risks for people with impaired immune systems keeping pet turtles.
J22 New master gene that regulates autoimmunity and regulatory T cells identified.
D19 FDA warns about two cases of progressive multifocal leukoencephalopathy (PML) in lupus patients treated with rituximab.
D12 New EPO-like drug mimics action of thrombopoietin: designed to treat thrombocytopenia.
D11 FDA proposes rules overhaul to expand access to experimental drugs.
N26 HDCN: Search index updated for audiofiles, slide/audio talks, articles, and abstracts
N14 Lymphostat (belimumab) effective against lupus in paper presented at rheumatology meeting.
N07 Michigan researchers link gene mutation in phospholipase C epsilon to podocytes, infantile kidney failure.
O26 Phase 3 trial design for belimumab to treat SLE approved by FDA
S27 La Jolla Pharm announces addition of new sites, reactivation of Riquent (abetimus) study to treat lupus.
S26 Genetic variations in MHC (major histocompatibility locus) posted on-line, clues for transplant and immune diseases.
S14 Spleen may be target for successful therapy of lupus.
S06 Chronic sinusitis linked to immune response to parasites and chitinase enzyme levels
S04 Mutation affecting platelets gives clues about crescentic glomerulonephritis
A04 New research gives clues as to why IVIG works in autoimmune disease (sialic acid).
J19 New egg freezing technique may be of interest to patients undergoing cytotoxic therapy.
J16 CARI (Australasian) Clinical Practice Guidelines published (53 free full text review papers!)
J16 Precise gene defects identified that cause lupus in mice.
J16 Rats that don't shower every day may be protected against autoimmune disease.
M24 Canadian scientists working to develop a synthetic replacement for IVIG
A27 Stem cells replace or fix podocytes damages in animal model of Alport syndrome
F26 Mystery solved: Gold's power against autoimmune diseases defined
F21 Is there a way to avoid the bladder toxicity of cyclophosphamide?
F12 Anti-malarial drugs lower elevated TNF-alpha levels in lupus patients.
F01 Stem cell transplants offer hope against lupus.
J28 Enhanced oocyte cryopreservation method (of interest to GN patients requiring cytotoxic therapy).
J19 Commonly used antidepressants may also affect the immune system.
J11 Infection fighting protein (cryopyrin) may be key to auto-immune disease.
D06 Annals paper shows that plasma exchange does not help in ARF due to MM.
N23 US RCT shows mycophenolate better than cyclophosphamide to remit lupus nephritis
N17 Genetic profiling identifies 10 genes linked to severity of lupus.
N17 Canadian study suggests that drinking too much water can harm kidneys.
N16 Trichostatin may reduce premature atherosclerosis in lupus patients.
N16 High HDL level is pro-atherosclerotic in lupus patients.
N08 Protein discovered that is key to survival of E. coli O157:H7
N07 Are epigenetic changes in histones the key to lupus autoimmunity?
N07 Parasitic worms may hold key to immunosuppression.
O26 ASN Renal Week 2005 abstracts now available on-line.
O17 Smoking ups risk of thrombosis in lupus patients.
O16 Novel DnaJP1 rheumatoid arthritis drug works without being immunosuppressive.
O12 CD19 monoclonal antibodies suppress B cells better than rituximab.
O12 New immunosuppression strategy has little weight, and in fact is in outer space.
O09 SEPS 1 gene on chromosome 15 plays key role in inflammation.
O07 Study of tonsillar lymph cells highlights role of autoreactive B cells in lupus.
O05 Human Genome's experimental lupus drug Lymphostat-B fails to meet goals.
O03 THi cells make IL-17 and may be key to some autoimmune diseases.
S27 Baxter announces new IVIG (intravenous immune globulin) product.
S21 O-GlcNac sugars, rather than cyclins, prime determinants of cell cycle control.
J10 Gene for immune deficiency syndromes found.
J08 Genomic mechanism of increased azathioprine toxicity identified.
J04 How cells with damaged DNA alert the immune system
J10 Researchers get first peek at amyoid structure.
J07 New methods may preserve fertility in girls receiving cytotoxic therapy.
J06 Fibrillex retards CKD progression in AA amyloidosis.
M30 Workplace solvent TCE linked to immune system disorders.
M30 Freezing eggs before chemotherapy in women to preserve fertility.
M28 Long-term effects of Canadian toxigenic E. Coli outbreak in the news.
M07 Immune gene with 20% prevalence linked to CAD, rheumatism, and MS.
M06 Nephrogenex licenses kidney disease molecular profiling technology.
M06 Novel cation transport gene linked to inherited form of FSGS.
M03 Schelling paper that is the basis for the dipstick protein-SC calculator
M01 Lupus in Native Americans from New Mexico often involves the kidneys.
A16 Lupus Research Institute launches awareness campaign with actor James Garner.
A09 CD36 may be a key component of innate immunity
A07 Lupus linked to Epstein-Barr virus IgA antibodies in Blacks.
M14 La Jolla lupus drug on track, but off the fast track in terms of FDA approval.
M02 Lupus Research Institute funds innovative research - get grant application.
F02 Lupus Research Institute increases funding for innovative research.
D02 Eating red meat associated with increased risk of rheumatoid arthritis.
N20 Another lupus drug in the pipeline - favorable animal studies
N11 Curagen working on monoclonal antibody treatment for IGAN
N07 North Carolina E. Coli outbreak grows, linked to State Fair, petting zoo
N05 Scientists identify new biomarkers for lupus
O30 ASN: Riquent lowers dsDNA levels in lupus patients as adjuvant therapy
O18 Mycophenolate effective to treat non-renal lupus
O18 Experimental lupus drug may also work against atherosclerosis
O15 La Jolla Pharma's FDA approval for lupus drug delayed: another RCT required
S24 Woman gives birth: Ovarian tissue frozen 7 years, reimplanted after chemoRx
S17 Urinary MCP-1 to follow the course of renal vasculitis
S16 Rituximab shows promise against lupus
S09 Prasterone (DHEA) effective as adjunctive Rx for lupus in RCT
S08 Cancer drug may reduce kidney disease in lupus
A29 A20 anti-inflammatory enzyme may prove to be a potent drug target
A26 NEJM: Bones OK in kids after steroid treatment of nephrotic syndrome
A23 IGF-1 receptor activation implicated in rheumatoid arthritis and autoimmunity
A18 Gene associated with lupus identified
A17 Group A streptococcus vaccine promising in early trials
A09 MMWR: Tuberculosis associated with TNF-alpha blocking drugs
J09 Lack of immune system protein prevents lupus-like condition in mice
J24 NEJM: Kidney disease no longer a killer for children
M15 NIH launches stem cell transplantation for lupus clinical trial
A06 Alliance for lupus research announces 6.7 M grant recipients
M03 Use of CYC + MMF or AZA for lupus published in NEJM
F24 Isotope studies quantify water intake in normal people - averages 2.5-3.0 L/day
F23 c-maf oncogene elevated in half of multiple myeloma cases
F21 CellCept for lupus in the news
J27 Cystic fibrosis protein CFTR shown to have adenylate kinase activity
J22 First int. symposium on albuminuria (NKF-ISN) to be held in New York in May 2004
J08 Anti-eosinophil therapy shown effective in treating hypereosinophilic syndrome
D16 La Jolla Pharmaceutical submits new drug application for anti-lupus compound
D10 Press reporting on MMF lupus study results from SUNY
D04 Multiple myeloma causing progenitor stem cell identified
D03 E. Coli O157 apparently spread by sawdust from exhibition hall rafters
D02 Revimid, a thalidomide derivative, may benefit multiple myeloma patients (PDF)
N11 Apoptosis of endothelial cells linked to heart risk in lupus patients
N01 Sulfatides (present on blood cells) are target for antiphospholipid antibodies
O28 TNF alpha linked to photosensitivity in lupus
O25 Mycophenolate trial results for lupus reported at Am Coll Rheumatology meeting
O22 Living with lupus: one patient's story
O22 Lactobacillus - vaccine combination lowers toxigenic E. Coli prevalence in cows
O15 NEJM: Autoantibodies in soldiers years before clinical onset of lupus
O06 NJ basketball star with FSGS on the rebound
S18 Cranberry juice may increase bleeding risk with warfarin
S08 Genetic approaches seek to eliminate O157 E. Coli gut colonization of cattle
S08 Vaccine against autoimmune disease to be tested
A25 Lupus Foundation of America to launch new patient-oriented magazine
A23 Lactoferrin spray on meat considered safe to fight E. Coli
A17 Philly petting zoo closed temporarily: possible source for toxigenic E. Coli
J29 O157:H7 antibody trial for HUS underway in Canada
J18 PPAR-alpha linked to steroid-induced diabetes and hypertension
J05 Argentina shuts McDonald, Burger King restaurants because of E. Coli fears
J04 Toxigenic E.Coli infected teens attending prom at Mississauga, Ontario
J03 ECSYSVAS: Cyclophosphamide can be replaced with azathioprine after remission
J25 NEJM: Bortezomib benefits a third of multiple myeloma patients
J14 How antibiotic therapy can worsen or cause HUS
J04 Hemolytic uremic syndrome tragic patient stories in the news
J02 Gene defect produces lupus-like disorder
M24 Phage transfer implicated in toxin-producing bacterial infections
M13 FDA approves proteasome inhibitor drug Velcade for multiple myeloma
M06 Staph aureus effect on B cells might be useful to treat lupus
A25 Bacteriophage approach can kill E. Coli, possibly also O157:H7
A12 Should we routinely text the urine for microhematuria?
A11 Athlete sues NSAID maker, claiming NSAIDs cause his proteinuria
M24 High-dose steroids linked to cardiovascular disease
M11 Fish oil may benefit lupus patients
F18 La Jolla Pharmaceutical lupus drug (Riquent) fails key test; stock plummets
F15 Trichostatin ameliorates lupus expression in mice
F12 Interferon genes linked to lupus in NIH study
F10 RNA interference halts hepatitis in mice
F10 RNA interference halts hepatitis in mice
J22 Rapamycin may be useful against lupus
J18 Amgen says Enbrel works against psoriasis in study
J14 Abbott enters TNF blocker fray with Humira
J10 High-dose cyclophosphamide regimen for lupus patients
N07 View abstracts from Am Coll Rheumatol Annual Meeting