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HDCN News Archive -- Hypertension, CV Disease
Feb03 Triglyceride levels predict stroke risk in postmenopausal women.
Feb03 Clopidogrel with aspirin does not prevent smaal subcortical strokes; increases bleeding risk
Jan17 Renal denervation surgery now available in Toronto, Canada.
Jan12 What is irisin and how does it regulate brown fat tissue?
Jan12 Routine aspirin may cause harm
Jan10 Dabigatran linked to risk of acute coronary events.
Dec15 Chewsing khat is bad for you if you have heart disease.
Dec13 Statins reduce plaque by affecting the CCR7 chemokine receptor on macrophages.
Dec06 Self-absorbing drug-eluting heart scaffold stent implanted in Montreal.
Nov28 McMaster study published in JAMA suggests a U-shaped relation between sodium intake and CV risk.
Nov28 Similar effects of beer and wine on risk of cardiovascular disease.
Nov21 Higher blood 25-D levels (> 100 ng/dL) linked to new onset atrial fibrillation.
Nov16 Stem cell treatment improves severe CHF in Lancet study.
Nov16 ASN; PRIMO study shows no benefits of paricalcitol on LVH in patients.
Nov16 Higher dose statins reduce coronary artery plaque.
Nov16 American Heart Association Scientific Sessions website.
Nov16 Niacin may not improve hard outcomes.
Nov16 CETP inhibitor more than doubles HDL cholesterol levels.
Nov16 Ain't necessarily so dept: Hypertrophic cardiomyopathy associated with long life.
Nov09 Extra-carotid to internal carotid artery bypass surgery of limited value after ministroke.
Nov01 Am Heart Assoc High BP Research Council Fall 2011 Meeting abstracts
Oct28 Medtronic launches clinical trial of its renal denervation device.
Oct26 Apixaban better than warfarin for atrial fibritllation.
Oct26 Taking at least one BP med at bedtime lowers cardiovascular risk.
Oct20 CDC via MMW publishes usual sodium intakes of US individuals, 2005-2008.
Oct18 St. Jude Medical announces first clinical use of renal denervation technology.
Oct18 BNP biomarker-guided therapy of heart failure markedly lowers complication rate.
Oct14 ASN Renal Week 2011 abstracts now available.
Oct14 MMWR (CDC): Incidence of heart disease in the U.S. declining from 2006 - 2010 (pdf)
Oct14 Bacteria-derived bile acids linked to efficacy of statins.
Oct11 Thiazides may be especially useful to treat hypertension from calcineurin-inhibitor drugs.
Oct11 Link between FGF23 and LVH strengthened by studies in mice, rats, and patients.
Oct04 Salt institute requests that U.S. agencies remove salt restriction from new dietary guidelines.
Sep27 Plaque disruption explains heart attacks in women with normal coronary angiograms.
Sep21 Exposure to vehicle exhaust fumes from traffic can trigger heart attacks with a 6-hour window.
Sep21 cMyBP-C protein may be new diagnostic marker for acute heart attack.
Sep15 Cryoablation treatment of atrial fibrillation shows promise.
Sep15 NEJM: Apixaban better than warfarin to treat atrial fibrillation.
Sep13 Body clock found to regulate platelet function
Sep03 Poor sleep quality increases risk of high blood pressure.
Aug30 Will the chocolate-eating craze impact oxalate load in patients with CKD?
Aug30 European Society of Cardiology 2011 symposium home page
Aug30 Donor heart arrives warm and beating in experimental organ transfer device.
Aug30 Higher salt intake and low activity linked to increased risk of dementia in the elderly.
Aug30 European registry tracks outcomes with ablation therapy for atrial fibrillation.
Aug30 Weight-loss simulatino tool allows prediction of efficacy of dietary interventions for obesity.
Aug30 Adoption study underlines role of genetics in causation of heart disease.
Aug23 New computed tomography heart scan exposes patients to 90% less radiation.
Aug19 High serum phosphorus may accelerate CKD progression, block effects of ramipril.
Aug03 4-D Substudy suggests that low homoarginine levels associate with sudden death.
Jul21 FDA approves ticagrelor (Brilinta) to treat acute coronary syndrome.
Jul21 Stress cardiomyopathy is real and affects a broad range of elderly patients.
Jul19 Intravenous ribose helps recovery from heart attack. A potential dialysate additive to prevent stunning?
Jul19 Carvedilol found to improve intradialytic hypertension in pilot study.
Jul12 Kv7.4 potassium channel in blood vessels linked to control of blood pressure.
Jul12 Therapeutic hypothermia betters outcome post cardiac arrest - why not a dialysis system?
Jul12 FDA approves trial of renal artery SNS ablation by catheter using Ardian/Medtronic system.
Jul12 Higher sodium and lower potassium intake independently link to mortality in NHANES
Jul07 American Heart Association maintains its guidance about 1.5 g/day max sodium intake.
Jul07 Cochrane Library review questions benefits of salt reduction in terms of hard outcomes.
Jul07 Either excessively high or low sodium intake in pregnant rats adversely affects nephron number and kidney function in their offspring.
Jul05 Anti-smoking drug varenicline may have adverse cardiovascular effects.
Jul05 NSAIDs associated with increased risk of atrial fibrillation.
Jul05 Alpha-tocotrienol, a form of vitamin E, may protect brain cells after a stroke.
Jun28 Collagen-binding protein allows dental S. mutans bacteria to attach to heart valves.
Jun28 Visceral fat decreased by increased intake of soluble fiber and exercise.
Jun28 New hybrid minimally invasive surgical procedure to treat atrial fibrillation
Jun21 Shorter pause between stopping CPR and administering electroshock linked to higher survival.
Jun09 FDA-mandated labeling change for simvastatin regarding risk of higher dosages.
Jun09 Pretreatment of mice with thymosin beta 4 induces cardiac repair after induced infarct.
Jun09 SHARP trial (simvastatin plus ezetimibe in CKD) results published in the Lancet.
Jun09 FDA: Myopathy risk of high-dose (80 mg) simvastatin close to 50%; limitations to use recommended.
Jun01 Histone deacetylase inhibitor reverses LVH in a mouse model.
May31 Higher fat, lower carb diets pose little cardiovascular risk over the short term.
May28 MGmin-LDL identifed as a subtype of LDL associated with cardiovascular disease.
May28 Chronic estrogen exposure may increase blood pressure via superoxide; reversed by resveratrol.
May26 Addition of niacin to simvastatin fails to protect the heart and may increase stroke risk
May25 Nineteen percent of young adults found to have high blood pressure.
May22 Epleronone reduces the incidence of atrial fibrillation in class 2 heart failure.
May19 Deuterium-enriched vitamin A slows rate of age-related macular degeneration in a mouse model.
May19 Dairy consumption does not elevate cardiovascular risk in Costa Rican study.
May19 L-arginine-rich foods lower risk of pre-eclampsia.
May17 FDA advisory panel will convene to reconsider approval of fenofibrate
May16 IDOL, inducible LKL receptor degrading molecule, may be target for cholesterol lowering.
May16 KLF14 gene may be a regulator of body fat, obesity, and cholesterol.
May15 Telemedicine monitoring of heart failure patients strikes out.
May12 Losartan might protect against disuse muscle atrophy (in mice).
May03 Link to EPOGH study in JAMA on urinary sodium and CV death risk.
May03 Ain't necessarily so: Observational study suggests lower sodium intake increases risk of death from heart attack and strokes..
Apr29 Work more than 8 hours a day? You may be setting yourself up for a heart attack.
Apr26 25D blood level differences explain 40% of difference in blood pressure between blacks and whites.
Apr25 The cardiologists weigh in on how to treat blood pressure in the elderly.`
Apr25 Oops! High levels of omega-3s, as indicated by DHA, associated with high-grade prostate cancer.
Apr22 Prolongation of the QT interval on sudden standing a marker for sudden death risk.
Apr22 ACE inhibitors may trigger recurrence of breast cancer: an unexpected finding
Apr20 Intensified ultrafiltration in an attempt to control blood pressure linked to more access complications.
Apr20 Calcium supplements linked to increased heart attack risk in older women.
Apr12 On-sitne heart attack response team provides median door to angioplasty balloon time of 47 minutes
Apr12 Vitamin D improves flow-mediated vasodilatation in overweight African American subjects.
Apr12 25D levels below 15 mcg/L linked to increased risk of age-related macular degeneration
Apr07 Ciliary neurotropic factor delivered by encapsulated cells may help age-related macular degeneration
Apr06 Implanted neck baroreceptor buzzer lowers blood pressure in controlled study.
Apr06 Gut bacteria may convert choline to pro-atherogenic compounds. Caution re supplements.
Mar29 Large study using ambulatory BP monitoring shows that many cases of apparent resistant hypertension are really white coat readings.
Mar29 Small, randomized trial of renal denervation shows benefit in treating resistant hypertension.
Mar29 Whole fiber breakfeast cereat consumption associated with lower blood pressure.
Mar24 Ok, you know about FGF23. But FGF19 may be even more important in glucose metabolism.
Mar23 So if we cut out fruits (potassium) and whole grains (phosphate), we also cut out fiber. Is that a good thing?
Mar17 Cardiac injection of autologous stem cells markedly improves heart failure.
Mar12 Disruption of circadian cycle can lead to fatty liver.
Mar12 Coffee drinking linked to reduced stroke risk in women.
Mar12 Wnt1 can stimulate new blood vessel formation and also improve blood flow.
Mar02 Glycogen synthase kinase 3 beta (GSK3B) antibody lowers blood pressure in animals.
Mar02 NSAID use linked to erectile dysfunction
Feb28 Abnormal cubilin gene linked to albuminuria
Feb28 Gut bacteria can affect hepatic lipid metabolism
Feb24 Like pecan pie?
Feb22 Routine measurement of central blood pressure becoming more practical.
Feb18 Where the sodium comes from: sauces, bacon, bread, milk, and cheese
Feb17 New aldosterone-related gene mutation linked to severe hypertension
Feb11 Apixaban may prevent strokes more efficiently than aspirin in atrial fibrillation.
Feb11 New genetic cause of primary hyperaldosteronism identified, and it's not rare.
Feb09 Salt and diet soda ingestion linked to increased risk of cerebrovascular events
Feb07 Pivotal discoveries in age-related macular degeneration.
Jan31 New USDA sodium guidelines recommend sodium intake < 1.5 g/day for individuals with CKD, HTN, or DMj
Jan21 Hickey paralyzes woman (seriously)
Jan15 National Library of Medicine's Daily Med website for quick access to drug package inserts.
Jan14 American Heart Association calling for sodium reduction to 1.5 g/day for everyone.
Jan14 Let me tell you one thing about nurses who eat blueberries...
Jan12 JAMA: Candesartan linked to better survival in heart failure than losartan.
Jan12 Common painkillers linked to increased risk of vascular complications.
Jan12 NEJM: Cholesterol efflux capacity from macrophages, a new measure of HDL action, linked to carotid intima-media thickness.
Jan11 Stem Cell treatment of age-related macular degeneration on the horizon.
Jan10 Statins may be harmful after hemorrhagic stroke.
Jan06 Extended-release clonidine now available for sale in the United States.
Dec28 FDA clears Novartis' triple antihypertensive drug for marketing.
Dec18 FDA approves Medtronic cryoablation device to treat atrial fibrillation.
Dec17 Beetroot juice may increase walking distance in the elderly.
Dec15 Ain't necessarily so: No link between serum 25-D levels and cardiovascular mortality.
Nov30 Source of protection against saturated fat (Angptl4) found, and 3% of people don't have it.
Nov17 Radiofrequency zapping of renal nerves in CKD lowers blood pressure substantially.
Nov17 NEJM: New CETP inhibitor anacetrapib shows promise in affecting LDL and HDL levels
Nov16 Nevada doctor in hot water for prescribing BP pills over the phone without seeing the patient.
Nov16 Xarelto and other warfarin alternatives about to hit the U.S. market.
Nov14 AHA 2010 abstracts: Percutaneous Coronary Intervention in High-Risk Populations: Diabetes and Kidney Disease
Nov14 AHA 2010 abstracts: Diabetes, Metabolic Syndrome and Chronic Kidney Disease
Nov14 AHA 2010 Abstracts: Cardiorenal syndrome: pathophysiology
Nov14 AHA Scientific Sessions ongoing in Chicago, Nov 13-17.
Nov14 Large RCT has good news and bad news for nesiritide (Natrecor).
Nov11 Brass, even in modern plumbing fixtures, continues to cause lead-contamination of drinking water.
Nov08 Cerebral microbleeeds common with aging.
Oct22 Salt sensitivity linked to vasopressin via induction of brain protein synthesis.
Oct18 Susceptibility to hypertension in Blacks may be related to too much aldosterone.
Oct18 Fenretinide reduces the risk of transformation of dry to wet macular degeneration.
Oct15 American Heart Association position paper on smokeless tobacco products.
Oct13 One in five West Virginia 5th graders may have high blood pressure.
Oct13 Want to lower blood pressure? Eat more watermelon for it's L-arginine precursors (but watch the K !)
Oct12 Pharmacy benefits group attempts to predict drug non-compliance at an early stage.
Oct12 International Society for Hypertension in Blacks recommends aggressive treatment.
Oct09 More on FDA-mandated withdrawal of Meridia (sibutramine) from the U.S. market.
Oct05 NIH adds more patients over 75 to SPRINT blood pressure goal trial.
Oct04 New evidence suggests that dietary intake of saturated fats has limited risk of CV disease.
Sep25 Transcatheter aortic valve replacement associated with markedly improved survival.
Sep22 CMS releases new proposed qualiity measures developed by Arbor Research (1.5 mb pdf file)
Sep15 Defective ABCB4 gene impedes cholesterol excretion into the bile.
Sep09 FDA issues new safety alert re gadolinium-containing contrast agents and NSF.
Sep07 Vegetable-based low-carbohydrate diets better than those rich in animal protein
Sep02 NEJM: Increased cardiovascular risk from weight loss drug sibutramine.
Sep02 AASK trial analysis suggests lower BP targets may benefit African Americans with proteinuria.
Aug31 Large study debunks notion that statins may be associated with cancer.
Aug31 Apixaban reduces stroke risk more than aspirin in patients with atrial fibrillation.
Aug26 Analysis of large claims-based dataset suggests heart risks for rosiglitazone and pioglitazone are similar.
Aug26 New NICE hypertension in pregnancy guidelines issued; recommend daily aspirin
Aug26 Back to the future: Renin profiling claimed to be useful in predicting response to RAAS inhibitors or beta-blockers.
Aug26 Naringenin from grapefruits shows promise as a treament for type 2 diabetes
Aug24 Randomized trial shows that drinking water before a meal reduces calorie consumption.
Aug20 Binge drinking markedly increases death risk in subjects with hypertension.
Aug20 Adding fish oil to low fat diet helps metabolic syndrome.
Aug15 ALLHAT long-term follow-up study confirms advantages of diuretics.
Jul30 Calcium supplements increase the risk of heart attack in postmenopausal women.
Jul24 Marcrophage fatty acid synthase a new target to prevent atherosclerosis.
Jul20 FDA approves generic version of transdermal clonidine.
Jul16 APOL1 gene increases risk of kidney disease in African Americans.
Jul15 ACCORD (NEJM): HbA1c target < 6% and combo statin/fenofibrate Rx better for retinopathy.
Jul12 Abstracts from 2010 World Congress of Cardiology - Posters (274 page .pdf)
Jul12 World Congress of Cardiology 2010 oral presentation abstracts (100 page .pdf)
Jul08 Cholesterol can exit the blood via the liver into the intestine while bypassing bile.
Jul06 Got a thick neck? Might not be so good if you're a child.
Jul06 Cocoa flavanols increase angiogenic cell number.
Jul06 INVEST study published in JAMA: No benefit of targeting BP < 130/80 in diabetics vs. 130-140
Jul06 How water drinking increases blood pressure and sympathetic activity.
Jul02 Olive oil consumption downregulates gene activity associated with atherosclerosis.
Jul02 Sugary drink consumption raises risk of hypertension.
Jun30 NEJM: Is computed tomography safe?
Jun29 Can't decide if rosiglitazone is safe for the heart? Ask Consumer Reports.
Jun29 Video presentation summary of ACCORD trial results.
Jun29 KDOQI CKD guideline of BP < 130/80 is being questioned.
Jun29 Beetroot juice in the news as a means of lowering blood pressure and CV risk.
Jun29 New study shows no increased cardiovascular risk due to rosiglitazone.
Jun24 Selective estrogen compound activates cell-surface receptors only, may confer vascular protection.
Jun22 European Soc Hypertension 2010 meeting abstracts - June 21st.
Jun22 European Soc Hypertension 2010 meeting abstracts - June 19th.
Jun22 European Soc Hypertension 2010 meeting abstracts - June 19th.
Jun22 ENDO 2010 "abstracts 2 view"
Jun22 Daily new reports of ENDO 2010 meeting
Jun22 Genetic septet in control of platelet stickiness.
Jun18 Blood pressure of 110 and above in teenage boys presages HTN.
Jun13 Lancet study suggests that ARBs may be associated with a higher rate of lung cancer.
Jun11 Short stature increases risk for heart disease: an important confounder for BMI
Jun10 Bipolar disorders linked to hypertension
Jun10 Allopurinol markedly slows progression of CKD in small randomized trial.
Jun10 Why did heart attacks go down by 24% in Northern California's Kaiser patients?
Jun10 Continuous aspiration thrombectomy helps return brain function post major strokes.
Jun10 Ghrelin acting on MC4 receptors in the brain shown to affect serum cholesterol levels.
May30 The politics of salt reduction: the food industry fights back.
May29 Abstracts of the High Blood Pressure Research Council of Australia 31st Scientific Meeting.
May26 Drinking fewer sugar-sweetened beverages may lower blood pressure.
May26 B cell genes characterize transplant patients who do well after stopping immunosuppressives.
May26 High levels of HDL cholesterol do not always protect.
May21 Use of Viagra associated with long-term hearing loss.
May18 Pregnenolone sulfate may reduce inflammatatory mediator production by blood vessels.
May18 Higher blood pressure found in people living in urban areas
May12 Working overtime increases heart risk
May06 Having a TIA? Eat some dark chocolate.
May06 New atherosclerosis gene gives promising results.
May05 Mitochondrial DNA strongly linked to stroke risk
May04 American Society of Hypertension program book (see RSS feed for audiofile link)
Apr30 SHR (spontaneously hypertensive rat) genome sequenced - 788 mutations found!
Apr30 New gene link to scleroderma found
Apr28 Anabolic steroid use in healthies impairs left ventricular relaxation by 50% and also ejection fraction.
Apr28 RCT shows that high-dose B vitamins associated with increased risk of progression and CV events in diabetics.
Apr20 About 6 kg of weight loss in obese subjects markedly reduces pro-inflammatory immune dysfunction.
Apr20 Institute of Medicine sodium report - full text
Apr20 FDA Statement on Institute of Medicine sodium report
Apr20 Institute of Medicine, Harvard researchers call for rules for sodium reduction in food
Apr20 Diets high in added sugar raise heart disease risk.
Apr19 Bad news and more bad news: Gene that makes you fat melts your brain.
Apr19 Gamma prime fibrinogen levels in the top quarter equals a 7-fold increase in MI risk
Apr14 Bariatric surgery lowers pregnancy complication risk in obese women
Apr13 High glycemic index carbs increase heart risk in women.
Apr11 Generic losartan and losartan + HCTZ now available
Mar30 Eating 1 small square of chocolate per day lowers CV risk by 39%
Mar23 High-fructose corn syrup associated with liver scarring in patients with NAFLD.
Mar22 Inventor of beta-blocking drugs, Scottish scientist Sir James Black, dies.
Mar22 NDT early: Hemodialysis causes microemboli to enter the circulation.
Mar22 Fibrillin-1 and TGF beta linked to scleroderma
Mar22 High fructose corn syrup = table sugar in terms of fructose content, but not in terms of obesity.
Mar19 JACC paper: Rosuvastatin in CKD subgroup of the JUPITER trial
Mar19 High-dose rosuvastatin reduces mortality in CKD patients by 44%.
Mar15 Valsartan and nateglitidine of no use in reducing CV death in prediabetics.
Mar15 Level of myeloperoxidase strongly associated with CAD mortality.
Mar15 ACCORD trial combination fibrate plus statin results (NEJM, pdf)
Mar15 ACCORD trial lower BP target results (NEJM, .pdf)
Mar15 ACCORD trial results released at ACC: BP lower than 120 or addition of fibrates have no benefit in diabetics.
Mar12 Plavix gets new FDA warning regarding reduced efficacy in 3% slow activators.
Mar12 Spikes in blood pressure predict stroke risk better than high average readings.
Mar11 NEJM: Thyroid hormone analogue lowers LDL cholesterol in statin-treated patients.
Mar04 NEJM: Glycated hemoglobin linked to CV death risk in nondiabetic adults.
Mar02 3 different diets equivalent in terms of improving carotid artery atherosclerosis.
Mar01 Leukocyte biology suggests that simvastatin may increase infection risk.
Feb23 AHA/ACC issue Science Advisory re heart risk and thiazolidinedione drugs.
Feb23 New cardiac CT scanners with 320 detector rows expose patients to 90% less radiation.
Feb22 Mutations in gene encoding K channel KCNN3 associated with atrial fibrillation.
Feb12 Tetrahydrobiopterin (BH4) a drug already used in humans, prevents diastolic heart failure in mice.
Feb10 Statins associated with a 40% reduction in risk of cataracts
Feb09 Even mild hypokalemia in heart failure patients with early-stage CKD associated with increased mortality.
Feb08 What is "third-hand smoke" and why is it potentially dangerous?
Feb04 New metaanalysis debunks link between saturated fat intake and heart disease.
Jan27 ASH 25th Annual Scientific Meeting to be held May 1-4, 2010 in New York City.
Jan27 Think you know how platelets are made? Guess again.
Jan27 New software allows 3D imaging during coronary angiography.
Jan26 AJKD: Comments on AURORA study results on use of statins in CKD patients.
Jan25 MMWR: Prevalence of abnormal lipid levels among youths
Jan21 NEJM study quantitates benefits of salt reduction on CV outcomes.
Jan14 Alzheimer's disease might be detectable by a retinal exam.
Jan13 BPA (bisphenol A) linked to cardiovascular risk.
Jan12 Intranasal and intracranial TGF-alpha restores motor function after stroke in rats.
Jan11 CV and kidney progression risk tied to proteinuria may be affected by race.
Jan07 UCLA study shows metformin to be safe in patients with diabetes and advanced heart failure.
Dec29 Inner ear organs can alter brain blood flow, affect postural hypotension, dizziness.
Dec29 Renal sympathetic nerve ablation being tested in the UK to treat hypertension
Dec23 American Heart Association's selection of top 10 research advances
Dec23 Aggressive BP treatment in patients over 80 may result in increased mortality.
Dec21 24-h BP monitoring disturbs sleep in some, artifactually affecting the amount of nocturnal BP dipping.
Dec21 Genetic studies clarify differing European and West African components of inheritance in African Americans
Dec07 NEJM: Dabigatran as good as warfarin for venous thromboembolism prevention.
Dec04 Blood clot risk increased up to 70 times as long as 6 weeks after surgery.
Dec02 Heart failure linked to gene variant affecting vitamin D activation.
Dec01 TLR2 (toll-like receptors) linked to inflammatory damage in atherosclerotic plaque.
Nov27 Stress-related blood pressure linked to phosducin.
Nov26 Instead of looking to get omega-3s from fish, look to the algae.
Nov25 Feeding time a major factor on gene induction circadian variability
Nov25 High salt intake linked to risk of stroke and cardiovascular disease.
Nov25 Nexilin mutations identified as a cause of dilated cardiomyopathy.
Nov19 Workers exposed to secondhand smoke in outdoor environments have elevated blood levels of cotinine.
Nov19 Cigarette smoke found to be contaminated with many pathogenic bacteria.
Nov18 Niacin plus statin no better than niacin alone in elderly patients with CAD.
Nov18 NEJM: IV iron improves functional capacity and QOL in heart failure patients with iron deficiency
Nov17 Scientific sessions of the American Heart Association portal
Nov17 FDA: Omeprazole and clopidogrel drug:drug interaction reducing efficacy of clopidogrel
Nov17 NEJM: Continuous flow LV assist devices markedly improve survival in severe heart failure.
Nov15 NEJM: Editorial regarding the HALTS trial (ezetimibe vs. niacin)
Nov15 NEJM: Extended-release niacin better than ezetimibe (Vytorin) for atherosclerosis reduction
Nov14 ASTRAL study published in NEJM: No benefit of revascularization in renovascular hypertension.
Nov14 Children with CKD often have undetected hypertension that is associated with LVH.
Nov14 Excessive ingestion of selenium supplements can increase cholesterol by 10%
Nov14 Getting fat recently? Maybe too many Firmicutes bacteria in your gut.
Nov10 Obesity and hypertension are independent risk factor for left atrial enlargement with aging.
Nov06 CJASN: Higher phosphorus levels in preESRD patients linked with coronary artery calcification.
Nov04 Off-pump bypass surgery comes up short in RCT against older method
Nov03 Role of aspirin in primary prevention of cardiovascular disease being questioned.
Nov03 Statins may protect against deep venous thrombosis
Oct29 NIH launches SPRINT RCT to study systolic BP target effect on progression into CKD.
Oct26 Blue-light filtering increases macular pigment, may protect against dry macular degeneration.
Oct13 Melanocytes in the heart? Protecting against atrial fibrillation?
Oct06 Cochrane review finds that B-vitamins of no benefit in preventing CV complications.
Oct06 Minocycline protects against ischemic stroke in animal models.
Oct01 JASN: Pioglitazone prevents age-related decline in renal morphology and function.
Sep24 Vitamin D deficiency in premenopausal women associated with hypertension later in life.
Sep24 200g/day fructose supplement increases systolic BP by 6 mm Hg, prevented by allopurinol.
Sep24 AJKD issues containing KDOQI guidelines now freely available as .pdf files
Sep17 Vitamin K deficiency may be widespread, according to a new theory.
Sep14 Implantable defibrillators may not benefit women.
Sep01 European Soc Cardiol 2009 meeting website
Sep01 Addition of valsartan lowers CV mortality in Japanese patients in the Kyoto heart study.
Sep01 Early stage CHF patients benefit from cardiac resynchronization therapy.
Sep01 How much DHA is enough for an anti-atherosclerotic effect? 200 mg
Sep01 Prophylactic use of aspirin in asymptomatic atherosclerosis of no benefit in RCT.
Sep01 CO linked to increased CV risk; might this explain the higher CKD risk as well in urban areas?
Sep01 Hormonal therapy for prostate cancer associated with increased cardiovascular risk.
Aug30 NEJM: Ticagrelor better than clopidogrel as an anti-platelet agent post acute coronary syndrome.
Aug30 NEJM: Free full text paper on dabigatran vs. warfarin for stroke prevention in atrial fib.
Aug30 Pradaxa (dabigatran) outperforms warfarin by a mile for stroke prevention with a. fib.
Aug28 About 1/3 of people don't activate clopidogrel very well due to gene variants.
Aug28 Should pregnant women avoid mushrooms? Ergothioneine levels high in pre-eclampsia
Aug28 New gene controlling formation of adipocytes identified.
Aug28 Warfarin use associated with increased stroke risk in hemodialysis patients with a. fib.
Aug24 Mice eating a low-carb diet show increased atherosclerosis and decreases in vascular progenitor cells.
Aug24 Is reduction in liver fat the key to the benefits of an alternate-day diet?
Aug24 FDA announces ongoing monitoring of liver injury associated with Orlistat.
Aug21 Excess cholesterol can affect heart rhythm via potassium channels
Aug21 When vitamin D levels low, macrophages get overloaded with cholesterol.
Aug20 Oxycholesterol an important new heart disease risk; high in fried fatty foods.
Aug19 Klotho gene reduces blood pressure and extends lifespan.
Aug18 Whole grain cereals have polyphenol content similar to fruits and vegetables.
Aug06 Blood transfusions in cardiac patients associated with markedly increased mortality.
Aug06 Hypertension associated with VEGF-inhibitors linked to nitric oxide.
Aug03 Millions of U.S. children low in vitamin D
Aug03 TV viewing time associated with higher blood pressure in children.
Aug03 Evidence mounts for cardioprotective effects of fish oil.
Jul31 Lecithin found to have beneficial effects on fat metabolism via PPAR-alpha
Jul31 Monocytes from spleen involved in recovery from myocardial infarction
Jul28 NIH halts trial of sildenafit in patients with sickle-cell disease and pulmonary hypertension.
Jul28 Like chocolate: Low-cal variety on the way (but watch out for the oxalate).
Jul26 Diets high in linoleic acid associated with increased risk for inflammatory bowel disease.
Jul21 In diabetics with heart failure, HbA1c levels of 7.1 to 7.8 at lowest risk of death; tighter control bad.
Jul13 Citrus-derived flavonoid prevents obesity and metabolic syndrome in mice.
Jul08 Is PEDF "the" link between obesity and type 2 diabetes?
Jul08 Study examines effects of stress on weight gain in US population
Jul08 Cochrane review suggests no benefit of lowering blood pressure below 140/90
Jul08 Anti-ageing effects of rapamycin in mice in the news.
Jul05 Aldosterone regulates ENac levels via Per1 - a protein mediating circadian rhythms.
Jul02 U.S. obesity problem intensifies.
Jul02 Enalapril or losartan markedly slow progression of eye damage in type 1 diabetics.
Jun30 Genetic study suggests that relationship between C reactive protein and CV disease is not causal.
Jun26 FDA to regulate tobacco.
Jun24 Analysis of large number of bariatric surgery patients shows the procedure to be relatively safe.
Jun19 Clopidogrel may increase risk of death in patients with diabetic nephropathy.
Jun17 Annals: Stents of no benefit in treating renal artery stenosis
Jun13 Higher vitamin D levels associated with successful weight loss in obese subjects on a diet.
Jun05 Aldosterone levels found to be increased in chubby teenage boys.
Jun01 Modified lycopene extract (ateronon) reduces harmful oxidation of fats.
May30 Results from 8 late-breaking clinical trials at Heart Failure 2009
May29 Risks of aspirin outweight benefits for primary prevention of stroke, MI in those with normal kidney function.
May26 Simplified chart may aid in diagnosing hypertension in children.
May25 Search all abstracts from the World Congress of Nephrology 2009
May25 Gene variant found that increases risk of both severe periodontitis and myocardial infarction.
May22 Fenofibrate reduces amputation risk in diabetics.
May18 Heart disease patients who are overweight do better and live longer.
May15 Use of CT angiography in the emergency room to help diagnose chest pain found to be cost-effective.
May15 JASN early release: Low 25-D levels associated with coronary artery calcification progression
May15 High triglyceride levels associated with diabetic neuropathy
May15 Interventional study in mice links cytomegalovirus infection to high blood pressure.
May14 Monotherapy with DARA, an endothelin and angiotensin I receptor antagonist, lowers BP a lot.
May14 ALLHAT follow-up study confirms benefits of chlorthalidone.
May11 UMOD gene, associated with Tamm-Horsfall protein production, linked to kidney disease.
May11 Cyclophilin may play a key role in arterial damage associated with atherosclerosis.
May11 Vitamins C and E block improvement of insulin sensitivity with exercise.
May08 Low BP associated with strokes and MI in patients with coronary artery disease.
May08 Combining dieting with exercise while standing/sitting/kneeling on a vibration plate machine lowers abdominal fat.
May04 8th Annual Prevention in Renal Disease Conference, September 25-26, 2009 in Toronto.
Apr30 Urine screening test seems to predict presence of atherosclerotic disease.
Apr26 Statins may reduce prostate inflammation and reduce risk of prostate cancer
Apr26 Sodium in prepared foods frustrates attempts to implement low sodium diet in CHF patients.
Apr26 Prostaglandin 2-alpha may be new target for control of blood pressure and atherosclerosis.
Apr23 Low-sodium vegetable juice may help reduce body fat in patients with metabolic syndrome.
Apr22 Alzheimer beta-amyloid can be degraded, and some drugs can increase breakdown rate 7-fold.
Apr18 New stem cell treatment for age-related macular degeneration in development.
Apr17 New discoveries on how collagen activates platelets may lead to new treatments to prevent clotting.
Apr16 Heart risk in diabetics may be exaggerated.
Apr16 Endothelin A receptor antagonist darusentan shows promising results in resistant hypertension.
Apr14 Aspirin and similar drugs associated with brain microbleeds in the elderly.
Apr12 CXCL5, secreted by white adipose tissue, may be the link between obesity and inflammation and insulin resistance.
Apr11 Three papers on brown adipose tissue in this week's NEJM.
Apr11 One thousand 2007-2009 audiofiles and slide/audio talks added to HDCN's 20 topic-related channels.
A07 Chemokine CXCL5, produced by fat cells, linked to inflammation and insulin resistance.
A06 Chlorthalidone increases SNS activity, spironolactone does not
A01 Yeast-powered fuel cells (for implantable devices) derive energy from glucose in human blood.
M30 GNSOR-deficient mice markedly resistant to heart attacks.
M30 Lipoic acid supplements markedly lower triglycerides in an animal model.
M30 AURORA study confirms the 4D study: Statins of no benefit in dialysis patients.
M30 Radiofrequency ablation of renal sympathetic nerve activity results in sustained improvement in refractory hypertension.
M30 NEJM: Ventriculoplasty of no benefit when added to CABG in patients with CAD and heart failure.
M29 Link to slide/audio and audio symposia on HDCN
M29 American College of Cardiology 2009 - Day 3 newsletter
M29 American College of Cardiology 2009 - Day 2 newsletter
M29 American College of Cardiology 2009 - Day1 newsletter
M29 Crestor (rosuvastatin) lowers risk of venous thromboembolism by 34%.
M28 Corking shut the atrial appendage markedly reduces risk of stroke in patients with atrial fibrillation.
M26 AHA supports a lower sodium intake limit (1.5 g Na/day) for most Americans.
M26 Testing for endothelial function using a finger device that evaluates reactive hyperemia linked to CV outcomes.
M26 Preliminary data show potential benefits of catheter-based thrombolysis for stroke.
M26 Cholesterol crystals linked to arterial plaque disruption and heart attack.
M22 Ten genes associated with prolonged QT syndrome and risk of sudden cardiac death.
M22 Correct warfarin dose determined by 3 genes only.
M20 FDA panel gives nod to alternative to warfarin
M18 Another statin (Crestor, rosuvastatin) fails to show a benefit (rumor has it) in dialysis patients.
M17 Endothelial lipase linked to levels of good cholesterol
M12 HDL levels and glucose sensitivity linked to neck circumference.
M12 New anti-clotting compound derived from magnolia trees shows encouraging results in phase II safety study.
M09 Eating fish associated with increased intelligence in Swedish teens.
M04 Reduction of stroke risk associated with green/black tea drinking appears consistent and linear.
F26 Cornell researchers develop and market a point-of-care urinary sodium test strips to monitor salt intake.
F25 NEJM: Randomized trial of 4 different diets (low fat, low CHO, etc.) fails to find a single winner.
F23 Genes controlling atrial natriuretic peptide expression linked to hypertension.
F18 NEJM: Genetic testing helps predict warfarin dose.
F17 Ain't necessarily so series: oxidative stress may prolong, instead of shorten, life (worm study)
F11 Very high doses of candesartan effective in further reducing proteinuria.
F10 Vigorous exercise (running) may reduce the risk of age-related macular degeneration.
F10 American Heart Association focuses on the high risk of stroke in women
F09 LSR, lipolysis-stimulated lipoprotein receptor, found to be deranged in type 2 diabetes with obesity.
F03 Short-term growth hormone treatment attenuates muscle loss after bariatric surgery.
F03 FOXO3A gene variants associated with living beyond 100 in multiple parts of the world.
J30 Epoxide hydrolase inhibitor reduces heart failure in animal model
J30 Sulfenic acid may be reason for potent anti-oxidant effect of garlic.
J30 FDA mandates detailed hyperkalemia warning for Aldactone (spironolactone)
J28 The new study that caused the fuss about clopidogrel and proton-pump inhibitors.
J28 FDA cautions on combined use of clopidogrel and proton-pump inhibitors until more info is obtained.
J26 Animal study suggests benefit of statins in preventing stroke in patients with cerebral cavernous angioma or malformation.
J20 Randomized (DRIP) trial reports benefits of dry weight reduction in dialysis pts. on 24-h blood pressures.
J19 Three new genes linked to childhood obesity identified.
J19 Trial of stem cell treatment to treat stroke patients approved for recruitment.
J19 Indian subcontinent heart disease gene identified.
J17 Heart and Stroke Foundation of Ontario issues "alert" against combined use of ACEIs and ARBs.
J15 Source of endogenous salicylic acid identified as benzoic acid found in fruits and vegetables.
J12 High sodium to potassium ratio in the urine increases cardiovascular event rate.
J09 New anti-anginal drug acts by working on sodium channels.
J01 New Year's Resolution? Quit smoking. American Lung Association support info.
J01 MMWR: Lower acute MI rates after city implements smoke-free ordinance
D29 Study of Amish identifies a new gene linked to sodium control and hypertension
D18 JASN early: First morning urine better than spot urine to detect microalbuminuria
D15 FDA approves premounted renal stent system manufactured by Boston Scientific
D14 Study in the Amish links APOC3 gene mutation, triglycerides, and resistance to heart disease.
D13 New study shows links between 30 genes and cholesterol and triglyceride levels.
D13 Should nephrologists give beta-blockers to their patients with CKD?
D11 CJASN: Rosiglitazone may benefit patient with FSGS
D09 Statins adversely affect placental development in an in vitro model.
D04 NEJM study shows that irbesartan of no benefit to patients with diastolic heart failure.
D04 Liver fat, rather than abdominal fat or shape, may be main cardiovascular risk.
D03 NEJM: ACEI plus amlodipine better than ACEI plus a thiazide in terms of cardiovascular events.
D02 Depression increases risk of subsequent visceral fat gain in longitudinal study.
D02 Consumer Reports investigates sodium content of foods: salt is present where one may not expect
D02 Cardiologists debate NEJM study comparing coronary CT scans with percutaneous angiography.
D01 Canadians publish best practice recommendations for stroke care.
N27 New studies confirm importance of sirtuin pathway in mammalian ageing; attention focuses on resveratrol.
N26 Binge drinking may damage the heart via acetaldehyde activation of macrophages.
N21 Do your CKD patients still smoke? Who is still smoking in the US by state.
N18 New microRNA compound protects mice against heart failure.
N14 Renal Week: Relative vitamin K2 deficiency linked to vascular calcification in ESRD
N13 Catheter thermoablation of atrial fibrillation far superior to drug treatment.
N13 FDA: Review of atrial fib - bisphosphonate data suggests a weak or no relationship.
N11 Sleep apnea associated with increased risk of sudden death.
N11 AHA Scientific Sessions 2008 in New Orleans, LA: Daily News, Nov 8 -12.
N09 Rosuvastatin given to patients with normal cholesterol levels but high CRPs markedly lowers CV risk.
N04 Intraocular anti-VEGF drugs to treat retinal proliferative disoders may have a dark side.
N04 New SIRT1 activating drug may protect against diet-induced obesity.
O30 MYH9 gene variations linked to CKD in African Americans - researchers to present new data at Renal Week 2008.
O29 Grapes protect the hearts and blood pressure of rats fed a salty diet.
O28 VEGF-based screening test for pre-eclampsia foreseen based on new research.
O28 French company develops a next generation totally implantable artificial heart.
O28 Plavix (clopidogrel) may be inactivated by some calcium channel blockers.
O27 Runners burn more calories at rest than sedentary persons, and it's due to changes in the mitochondria.
O27 Risks of irregular heartbeat and atrial fibrillation increased with fosamax and other bisphosphonates.
O27 Pregnant women consuming flaxseed oil have a high (4x) risk of premature birth.
O27 Pentoxifylline lowers proteinuria alone or in addition to an ACE inhibitor.
O23 Hydrogen sulfide may be a key regulator of blood pressure.
O23 European watchdog agency suggests not using diet drug rimonabant due to depression side effects.
O23 New diet drug tesofensine appears to be remarkably effective.
O22 Journal of Renal Nutrition publishes composition of common salt substitutes.
O16 Fructose feeding induces high triglycerides and leptin resistance in rats.
O15 Resveratrol prevents liver fat accumulation in a mouse model of alcoholic liver disease.
O14 Resveratrol found in dark chocolate and cocoa.
O14 B vitamins of no help in slowing progression of Alzheimer's disease.
O13 Book Review: Clinical Guide to Use of Antithrombotic Agents in CAD
O13 Are you nuts about nuts? Nuts! One study fails to shell out any benefit.
O13 A series of abstracts presented at CRF meeting suggesting that triple anti-platelet therapy (adding cilostazol) improved outcomes.
O09 Retinylamine markedly slows age-related macular degeneration in an animal model.
O09 New physical activity guidelies: 30 minutes of moderate exercise 5 times per week;
O08 A single dose of EPO injected after a heart attack can limit apoptosis and thereby reduce heart cell damage.
O07 Farnesyl transferase inbitior (tipifarnib) reverses cardiovascular effects of progeria.
O07 Study illustrates importance of inflammatory macrophages in obesity; insulin resistance reversed by killing these cells.
O07 Even occasional smoking can impair arterial function for a prolonged period.
O07 Complement pathway and the innate immune system implicated in age-related macular degeneration.
O06 One-dollar-a-month polypill containing ASA, thiazide, ACEI, and statin to undergo clinical testing.
S30 Lancet: New genes found that link to gout.
S26 Aptly named horny goat weed found to be a source of specific phosphodiesterase inhibitors.
S25 In humans, as opposed to lab animals, caloric restriction does not lower IGF-1, but protein restriction does.
S22 Darapladib slows atherosclerosis in a pig model.
S22 Secondhand smoke exposure increases risk of peripheral artery disease in women.
S19 High-salt diet contributes very substantially to resistant hypertension.
S18 Are statins ineffective for protection against cardiovascular risks in women?
S18 New mechanism for cardiac arrhythmia discovered.
S18 Listening to Mozart lowers high blood pressure (really)
S16 NHANES data analysis links elevated urine bisphenol levels to diabetes, cardiovascular disease.
S16 Conbining thiazides with potassium-sparing diuretics markedly lowers cardiovascular mortality.
S15 Carvedilol and alprenolol, but not other beta-blockers, stimulate cellular protective pathway in the heart.
S12 Cardioprotective effects of alcohol ingestion may be due to aldehyde dehydrogenase.
S10 NEJM early release: Benefits of tight glucose control persist in type 2 DM at 10 years
S10 NEJM early release: Tight BP control has to be continued in type 2 diabetics; otherwise benefits are not maintained.
S05 Photographing what they eat helps dieters stick to weight-loss plans and identifies bingeing.
S02 Want to live longer? Take the stairs instead of the elevator.
A29 Singh and Furberg editorialize against use of thiazolidinediones due to CV risk and lack of CV benefit.
A29 100g/day of dark chocolate lowers blood pressure by 3 mm Hg.
A27 Debate flares: Can obese patients be healthy?
A26 Allopurinol lowers blood pressure in hypertensive adolescents
A26 Newer gated CT scans diagnose coronary artery disease and obviate need for angiography.
A22 Some evidence that Vytorin is, or maybe is not, associated with an increased cancer risk; FDA gets involved.
A21 AMAG receives fast track designation from FDA for ferumoxytol as an MRI contrast agent.
A19 Lowering homocysteine with folic acid and B vitamins fails to reduce CV events in heart disease patients.
A19 Obesity epidemic due to increased food intake, and not decreased activity level.
A15 When is a potential heart donor really dead? NEJM report raises some ethical questions.
A15 Lancet: ONTARGET study shows mixed results for combined ARB/ACEI therapy; greater reduction of proteinuria but a higher renal event rate.
A15 Bariatric surgery - induced weight loss helps, but does not cure, sleep apnea.
A13 Enhancing lysosomal receptors for chaperone molecules prevents aging of mouse livers.
A12 MicroRNA specific to endothelial cells associated with blood vessel branching, survival after cardiac infarction.
A08 FDA issues warning about risk of rhabdomyolysis when simvastatin is used with amiodarone.
A08 AHA issues recommendations for ambulatory BP monitoring is certain children and adolescents.
A05 IV calcium channel blocker wins FDA approval to treat acute hypertension.
A05 Baroreflex device to treat hypertension. A pipe dream? 200 million dollars raised so far says maybe not.
J31 Two new drugs have profound effects on exercise conditioning in mice.
J30 Does adiponectin have a dark side? Study associates it with increased cardiovascular risk.
J29 New study highlights risk of losing bone density while following a low-calorie diet for weight loss.
J29 Rember, a drug that is really a blue dye that prevents tau tangles, appears to slow Alzheimer's disease.
J29 Testosterone changes associated with perimenopausal increase in metabolic syndrome risk.
J29 Observational study suggests that statins may lower risk of senile dementia very substantially.
J24 Complement activation is increases in patients with age-related macular degeneration.
J24 In acute study, fructose increases lipogenesis relative to glucose.
J23 NEJM: Genetic mutation associated with most patients who develop myopathy on high-dose statins.
J22 Ezetimibe plus simvastatin drug trial shows no effect on aortic valve stenosis progression.
J19 Human blood vessels grown in mice
J17 Genetic variant identified that increases risk of elevated triglycerides fourfold in Asian Americans.
J17 U.S. population keeps getting fatter; esp. Alabama, Mississippi, and Tennessee.
J17 AHA to launch new journal focusing on cardiovascular outcomes trials and methodology.
J16 Doctors hopeful that improved blood thinners are on the horizon: Three new candidates.
J16 Annals: Low molecular weight heparin for 7 days better than stockings after arthroscopic knee surgery.
J12 Pioneering heart surgeon Michael DeBakey dies at age 99.
J10 Histone deacetylase (HDAC) inhibitors protect ischemic tissue from injury.
J08 Farm-raised tilapia fish has relatively low levels of omega-3 fatty acids.
J08 Fish oil plus red yeast lower cholesterol to the same extent as statin therapy.
J08 Overweight patients trying to lose weight lose twice as much if they keep a food diary.
J03 Statins spur glial progenitor cells to develop into oligodendrocytes.
J01 Caffeine intake increases rate at which muscle replenishes glycogen stores after exercise.
J01 Doxycycline-inhibitable protease activity increased in SHR rats; this also may explain various aspects of metabolic syndrome.
J30 AHA publishes cookbook focusing on healthy soul food recipes
J30 Sudden hearing loss associated with increased risk of future stroke.
J30 AHA launches hearthub.org, a website for patients.
J30 Prevalence of silent cerebral infarction in healthy (mean age 62) people at 11% in MRI study.
J26 Fructose, but not glucose, increases visceral adipose tissue and triglycerides, and lower insulin sensitivity.
J25 African Americans excrete less potassium in the urine, and it's not all due to dietary intake.
J25 Obesity drug rimonabant approved for NHS use in England and Wales.
J23 New source of cardiac stem cells found in the epicardium
J17 Big breakfast diet more effective than low-carb diet in maintaining weight loss.
J12 XBP1, stimulated by a high-carb diet, may be a new target for treatment of dyslipidemias.
J12 A subgroup of retinal cells linked to circadian cycle resetting and insomnia.
J12 FDA approves generic form of ramipril made by Lupin pharmaceuticals.
J11 Vitamin D protects heart-failure-prone rats against heart failure when fed a high-salt diet.
J10 One more argument against smoking: Increased risk of age-related hearing loss.
J10 Eating diet rich in oily fish associated with markedly reduced risk of age-related macular degeneration.
J09 115 year old woman found to have essentially normal brain on autopsy, with no evidence of Alzheimer's disease.
J06 Mechanism of action of niacin to increase HDL levels discovered.
J05 Study in mice suggests resveratrol has marked cardioprotective effects.
J05 NEJM: Aliskiren plus losartan lowers proteinuria in diabetics.
J03 Artificial blood vessel creation from smooth muscle cells makes major advances.
M28 Hope for stroke victims. Monkeys control prosthetic arm using brain waves to feed themselves.
M27 New scoring method for coronary artery calcification that takes into account extent of calcium coverage.
M27 Should HbA1c be used instead of plasma glucose to screen for diabetes?
M22 It's official: Home BP monitoring is now the standard of care.
M21 Genetic researchers identify numerous genes involved in synthesis and storage of fat in cells.
M21 After heart attack, bivalirudin better than heparin plus glycoprotein IIb/IIIa inhibitors.
M21 Modest red wine (but not beer) ingestion actually may lower risk of NAFLD - non-alcoholic fatty liver disease.
M20 Small adrenal masses found incidentally on computed tomography almost exclusively benign.
M19 Vaccine targeting amyloid beta protein prevents Alzheimer's disease in mice.
M19 American Society of Hypertension Annual Meeting (May 14-17) - abstracts at this link
M16 Small molecule found that can disassemble amyloid proteins associated with Alzheimer's disease.
M16 New NHANES analysis finds CV mortality increased in patients following a lower salt intake.
M15 Lower-dose tissue plasminogen activator treatment improves survival in patients with hemorrhagic stroke.
M15 Biopterin derivative may be effective treatment for severe heart failure.
M13 Preop beta blockers reduce heart attack risk but markedly increase total mortality.
M13 Prism eyeglasses expand view for patients with stroke-induced hemianopia.
M12 CPR rescuers do not need to stop compression while administering defibrillator shocks.
M12 Preeclampsia-like condition develops in mice with knockout of catechol-O-methyltransferase (COMT) gene
M09 Darapladib lowers the activity of inflammatory enzyme associated with vascular plaque.
M07 S100A1 protein found in heart, blood vessels; linked to heart damage and to hypertension.
M07 Women at high risk for CV events are not benefitted by homocysteine-lowering regimen of B vitamins (JAMA).
M05 ASN Renal Week abstract archives 2003-2006 now available on-line in .pdf format.
M04 Nature genetics: More obesity genes found
M02 New ACE 2 activator compounds lower blood pressure in rats and also reduce cardiac and renal fibrosis.
M01 Obesity linked to heart failure and inflammatory mediator elevation in observational study.
A30 Scientists synthesize molecule capable of releasing hydrogen sulfide over extended periods - possible role in donor organ preservation?
A29 High blood theobromine levels (presumably from eating chocolate) may protect against pre-eclampsia.
A28 Hypertension seen in the emergency department frequently misattributed to trauma, stress, and not followed up.
A25 First ever activator of ENAC sodium channel developed.
A23 High adiponectin levels linked to kidney dysfunction and albuminuria.
A22 FDA approves compact heart assist device from Thoratec.
A21 International study of chemicals in urine links blood pressure to diet and gut bacteria.
A21 Chocolate lowers LDL cholesterol by 5% in RCT.
A17 Low serum 25D levels associated with incrased peripheral arterial disease risk.
A15 Archives Int Med: Loop diuretics associated with lower bone density in men.
A15 Nurses' Health Study shows that women who follow DASH - type diet have lower risk of heart attack.
A09 NEJM: ACEI = ARB, and ACEI + ARB no better than either ACEI or ARB, in high risk patients with diabetes or vascular disease.
A09 Two enzymes associated with acetylation linked to heart muscle contraction.
A09 New Lifton study shows that some Bartter and Gitelman mutation heterozygotes are not rare, and are protected against hypertension.
A09 JAMA RCT shows American Indian tye 2 diabetics with LDL lowered to 70 have lower carotid IMT and LV mass than those with LDL lowered to 100.
A08 Slight modification to atrial fibrillation surgery improves the results.
A08 American Heart Association issues new guidelines for treatment of resistant hypertension.
A03 Daily dose of caffeine protects rabbit brains from high serum cholesterol.
A03 New Merck heart failure drug rolofylline gives encouraging results in Phase III trial.
A02 Treating hypertension in patients more than 80 years of age reduces death rate by 20%.
A02 Adenosine receptor antagonist shows promise in heart failure.
M30 NEJM: Ezetemibe lowers LDL cholesterol when added to simvastatin, but no effects on carotid artery thickness.
M27 Pretreating animals with high-dose folate lowers infarct size.
M27 NEJM: Prognostic value of coronary artery calcium content confirmed in large study.
M25 Archives study emphasizes heritability of early-onset hypertension in men.
M16 Blood vessel protein Robo4 reverses diabetic and age-related macular degeneration in mouse model.
M15 PR, QRS, and QT intervals on ECG are increased in apparently normal elderly persons over age 80.
M13 CMS: Medicare will continue to pay for CT cardiac scans for coronary artery calcification detection.
M12 New macrophage-related protein implicated in inflammatory disease.
M10 Mutated thrombin enzyme may be useful to treat heart attacks and strokes.
M07 Angiotensin vaccine moderately effective in lowering blood pressure
M06 7th Annual Prevention in Renal Disease Conference, Toronto, Sept. 19-20, 2008.
M04 Activating PPAR-delta suppresses inflammation in vascular tissues.
M04 Retinopathy may begin at lower blood glucose levels than expected.
M04 CAPON gene linked to QT interval and heart rhythm abnormalities.
F27 African American teenagers show a high prevalence of microalbuminuria.
F27 Up to 20% of persons taking aspirin show no effect on their platelet function.
F26 Heart attack rates fall in France following institution of national smoking ban in public places.
F26 FDA: Medication guide must be given to patients with each rosiglitazone (Avandia) prescription.
F23 New techniques for detecting air bubbles in blood vessels.
F21 Study suggests that Medicare part D patients use more cardioprotective drugs after MI and live longer.
F21 Salt-rich diet linked to obesity in children via sugar-containing soft drink consumption.
F20 New study confirms increased risk of kidney failure and mortality with aprotinin.
F15 Level of airborne particulates affects microvascular function.
F13 India in the middle of a catastrophic smoking epidemic
F13 University of Groningen study (PREVEND) emphasizes utility of treating hypertension in proteinuric patients.
F13 Genomic studies suggest that CETP (cholesteryl ester transferase protein) mutants protected against coronary effects of cigarette smoking.
F12 New blood test claims to identify pre-eclampsia reliably.
F12 Nocturnal noises raise blood pressure in sleeping subjects.
F11 Declining coronary artery disease rates made a U-turn in 2000, and now are rising.
F11 Reversible, but substantial, memory problems in a subset of women taking Lipitor.
F11 Very high Ang II levels found in chorionic villi of women with pre-eclampsia.
F09 Paradigm shift: Non-osmotic, inflammation-generating accumulation of sodium in the skin
F09 Death of waitress after acute asthmatic attack on entering workplace full of cigarette smoke.
F09 Calcium channel blocker treatment for HTN associated with 23% lower risk of Parkinson's disease.
F06 More on the halted NHLBI diabetes trial arm. Role of rosiglitazone use in the intensive treatment arm unclear.
F06 Beetroot juice found to lower blood pressure because of its high nitrate content.
F05 Richard Lifton, pioneer in the genetics of hypertension, receives Wiley Prize
F01 FDA warns about depressed mood, suicidal ideation in patients taking smoking cessation drug Chantix (varenicline)
J31 Sweetened soft drinks and fruit juices linked to increased risk of gout in men.
J29 Intravascular thrombolytic therapy effective against deep vein thrombosis.
J29 Diuretics produce better outcomes than other anti-hypertensive drugs in treating metabolic syndrome.
J25 Cox-2 inhibitors can cause arrhythmias by affecting potassium channels in the heart.
J22 Aspirin resistance increases risk of heart attack or stroke.
J16 Calcium supplements raise risk of heart attacks and stroke in elderly women.
J13 Pumping rat heart created by seeding a scaffolding with baby rat myocytes.
J09 Higher cholesterol levels linked to improved muscle mass with exercise in the elderly.
J09 Cannabinoid receptor blocking drug effective in causing weight loss.
J08 Risk of cardiovascular events markedly increased when 25-D levels below 15 ng/mL.
J07 Oxygen meter molecule, PHD1 knockouts survive hypoxia - potential application to early transplant viability, heart disease
D27 Aspirin increases liver enzymes in patients taking flutamide for prostate cancer.
D26 Triglycerids and non-HDL cholesterol linked to risk of stroke.
D25 Higher levels of HDL in diabetes may inhibit NO via myristic acid binding - outcome effects unknown.
D17 Drug that stimulates thyroid hormone beta receptors effective in lowering LDL cholesterol
D14 January JASN paper reports that PROActive (pioglitazone) associated with lower CV mortality in diabetics.
D12 More heart risks identified for Avandia.
D11 Physicians unaware of guidelines to treat patients with CV risk factors and metabolic syndrome.
D04 Different anticoagulant regimens after percutaneous coronary intervention yield identical results.
D04 Waistline growth on high-carb diets linked to liver gene.
D04 Renin-angiotensin linked to obesity and insulin-resistance in a gene knockout animal model.
N27 Glucose-insulin-potassium infusion after ST-elevated MI increases risk of heart failure.
N26 MRI documents second-hand smoke injury to the lungs.
N26 Nitrosyl cobamide shows promise as an NO-donor type of drug for hypertension or heart disease.
N12 Interleukin-1 receptor blocker rilonacept effective in treating chronic gouty arthritis.
N09 Simplified anti-hypertensive drug protocol seems to be more effective than more complex approach.
N08 MMWR: CDC reviews smoking prevalence in the U.S., and the results are not good.
N08 Skeletal muscle damage due to statins may operate through atrogin-1 and thus may be preventable.
N08 New nonsteroidal natriuretic hormone identified in human urine.
N07 Perioperative beta-blocker therapy shows mixed results in large RCT.
N07 Simvastatin, but not pravastatin, associated with sleep disturbances.
N07 Prazosin appears to block some glucocorticoid effects.
N07 AHA 2007 Scientific Sessions newsletter - Nov 7th.
N06 AHA 2007 Scientific Sessions Newsletter - Nov 6th.
N06 AHA 2007 Scientific Sessions Newsletter - Nov 5th.
N06 AHA 2007 Scientific Sessions Newsletter - Nov 4th.
N05 Large VA study identifies seasonal difference in blood pressure.
N03 Metabolites of flavonoid (quercetin) present in onions found to be anti-inflammatory.
N02 U.S. AHRQ releases report claiming equal efficacy for ACE-I vs. ARB in controlling blood pressure.
N02 WNK kinases identified as key regulators of blood pressure.
O25 Bayer issues additional guidance to physicians about Trasylol (aprotinin).
O25 Genzyme launches cholesterol-binding drug (Cholestagel) in Europe for patients with primary hypercholesterolemia.
O25 Uvulopalatopharyngoplasty may help some patients with obstructive sleep apnea.
O23 Global extent of obesity epidemic in the news.
O22 Chewing gum shown to help curb appetite and reduce cravings.
O19 Sudden hearing loss associated with erectile dysfunction drugs.
O12 Is fructose really that bad?
O12 Statins help preserve lung function during aging.
O08 FDA to warn of ultrasound cardiac imaging drug risks
O03 Mini-strokes (MRI study) linked to higher uric acid levels.
S25 New, synthetic version of heparin is patented.
S21 Study links TGF-beta and cholesterol to progression of atherosclerosis.
S20 Thiazide diuretics exacerbate fructose-induced metabolic syndrome.
S20 Post-reperfusion heart damage largely prevented by hydrogen sulfide.
S12 JAMA paper shows no benefit of lowering homocysteine in CKD
S10 Protein carbamylation, reflected by homocitrulline levels, strongly associated with atherosclerosis.
S07 Low vitamin D levels during early pregnancy associated with a fivefold increase in risk of pre-eclampsia.
S06 FDA approves first generic versions of carvedilol (Coreg).
S05 New ESC-ESH hypertension treatment guidelines from ESC 2007 (webcast)
S03 European Society of Cardiology 2007 meeting: Clinical Trials Updates
A27 Obesity rates climb in most states.
A27 Patient implanted with baroreceptor stimulating devise to treat refractory hypertension.
A22 Celecoxib - may reduce stent restenosis - overall safety in heart disease still remains to be deteremined.
A22 Hypertension frequently underdiagnosed in adolescents.
A22 Lack of benefit of vitamin E on heart disease may have been due to underdosing.
A20 Mechanism of adenovirus-induced obesity clarified.
A17 FDA warning letter issued emphasizing pharmacogenomic variability in warfarin metabolism among patients.
A13 New study confirms that vitamin C, E, and beta carotene, singly or in combination, of no benefit in heart disease patients.
A10 New research shows skeleton to be an endocrine organ via osteocalcin.
A08 Annals: New study questions the increased heart attack risk with Avandia; original NEJM meta-analysis claimed to have been flawed.
A06 Trial of anti-hypertensive therapy in the very elderly, more than 80 years of age, stopped early because of positive results.
J26 Diesel fume pollution linked to arterial inflammation and atherosclerosis.
J25 Obesity spreads among friends, study concludes.
J24 Soft drinks, including diet soft drinks, linked to 50% higher risk of metabolic syndrome.
J20 Cancer risk linked to CT scan for cardiac calcification (JAMA paper) in the news.
J19 Large VA study shows 50% reduction in Alzheimer / Parkinson risk with simvastatin, but not other drugs in the same class.
J19 Weight loss pill rimonabant associated with increased suicide risk.
J13 Scleroderma Outlook Improves as Survival Increases
J12 Hydroxychloroquine (Plaquenil) may be protective against developing type 2 diabetes.
J12 Serum levels of retinol-binding programs indicate level of visceral fat.
J12 Viagra may save lives in patients with pulmonary hypertension.
J11 Modified herpes virus keeps arteries free-flowing following procedures
J09 CCJM: A different approach to resistant hypertension, emphasizing hemodynamics and the physical examination.
J05 Alteplase may have pro-inflammatory effects - mitigated by cromoglycate.
J05 High sodium in many sandwiches in the news.
J05 Dark chocolate lowers BP slightly, raises levels of nitric oxide.
J02 How stress and high-calorie intact interact to increase weight and change body fat distribution.
J29 Particulates released during renal artery angioplasty can impair kidney function.
J22 FDA clears "computerized medication box" (EMMA) for U.S. market.
J19 FDA approves ambrisentan for treatment of pulmonary artery hypertension.
J19 Hypertension vaccine against angiotensin II shows positive results.
J15 Europ Soc Hypertens releases new, updated hypertension treatment guidelines.
J13 Link between restless legs syndrome and hypertension discovered.
J11 Isradipine slows Parkinson's disease development in mice
J07 New compound similar to aMSH, causing satiety, may be effective in controlling weight in the obese.
J07 Lipid chaperone protein ap2 may be a key to type 2 diabetes and its complications.
M31 Link between mercury and vascular disease involves phospholipase D.
M25 NEJM: Full text of meta-analysis that found an increased risk of myocardial infarction with rosiglitazone.
M25 Non-caffeine components of coffee lower serum uric acid levels.
M21 FDA issues safety alert for Avandia (rosiglitazone) over possible increased heart attack risk.
M21 Statins might have a role in management of hepatitis C.
M17 MMWR publishes regional stroke incidence data for the United States (2005)
M17 Debunking the slavery hypothesis of African American hypertension
M14 Effect of polyphenols (from apples, onions, green tea) on fat catabolism.
M14 Study shows unsuspected immunomodulatory effects of glucosamine.
M07 Liver, kidney damage in people taking large amount of green tea polyphenol supplements.
M07 Centrally acting ACE inhibitors may cut dementia risk in the elderly.
M07 Inactivation of ACAT2 enzyme protects fat-eating mice from atherosclerosis.
M04 Common gene variation associated with markedly increased risk of heart attack.
M03 Nicotinamide riboside, found naturally in milk, dramatically extends lifespan in yeast via sirtuins.
M02 Study highlights gender differences in susceptibility to kidney injury.
M01 Antithrombotics (e.g., aspirin) increase hemorrhagic stroke risk in the elderly.
A30 Activating PPAR-delta may burn fat and reduce metabolic syndrome risk.
A24 AGEs and food preparation may play an important role in chronic disease.
A20 New BMJ study on adverse effects of higher salt intake in the news.
A19 Fewer heart patients need antibiotics prior to dental procedures.
A18 Animal study suggests that changing to a low-fat diet can induce stress.
A15 JAM-1 protein acts in the brain to cause hypertension.
A07 Arthritis patients with CVD who take ibuprofen plus aspirin may greatly increase their cardiac risk.
A05 Think that eating only once a day will make you lose weight? Nope.
A05 Hatfield-McCoy family feud may be linked to bad temper due to heritable pheochomocytomas.
A02 High-prevalence hemachromatosis gene linked to increased risk of stroke.
M30 NEJM: Torcetrapib markedly elevates HDL cholesterol, but shows no benefit
M27 Implanted carotid artery baroreflex stimulator lowers BP by 16-20 mm Hg.
M27 New blood thinner may work without bleeding risk
M26 Drugs work as well as stents, study finds.
M26 Tolvatptan improves signs and symptoms in patients with CHF.
M26 Nesiritide safety trial shows neutral effect on mortality in CHF patients
M26 American College of Cardiology Annual Meeting March 24-27: Monday (26) Newsletter (.pdf)
M26 American College of Cardiology Annual Meeting March 24-27: Sunday (25) Newsletter (.pdf)
M26 American College of Cardiology Annual Meeting March 24-27: Saturday (24) Newsletter (.pdf)
M21 Long-term cessation of smoking may reverse arterial stiffness.
M19 Minisub developed to explore the interior of an arterial blood vessel.
M16 Fructose linked to deranged liver metabolism in rats, involving PPARs, leptin, and metabolic syndrome.
M16 Phthalate exposure linked to metabolic syndrome
M16 Chiropractic adjustment of C1 (atlas) markedly lowers blood pressure in randomized controlled trial
M16 Increased angiotensin 1-7 levels after ACE-I treatment may inhibit lung cancer
M16 Chest compressions without mouth-to-mouth better for out-of-hospital cardiac arrest
M16 An apple a day really does keep the doctor away.
M06 FDA approves aliskiren for treatment of hypertension.
M05 Dietary copper in the news after copper supplementation helps prevent heart failure in stressed rodents.
M05 Atkins diet may be the most effective with few obvious adverse effects
F28 Nifedipine found to mobilize liver iron stores in an animal model of hemochromatosis.
F26 Garlic powerless against cholesterol.
F22 Blood pressure across countries linked to level of happiness of its inhabitants.
F21 Apolipoprotein C1 linked to obesity and type 2 diabetes in American Indians.
F19 Relationship between circadian rhythm clock and blood pressure identified.
F19 CRP liver protein induces hypertension.
F16 MMWR reports on geographic variation in prevalence of heart disease in the U.S.
F14 Neutrophil-derived peptidase enzyme found to be a key player in development of aortic aneurysms.
J30 Need a new aortic valve? No problem. We'll put one in percutaneously.
J30 One third of young people who died suddenly and inexplicably had genetic arrhythmic heart defects.
J29 Health benefits of fruits and vegetables apply to their juices as well.
J29 Major link in brain-obesity puzzle found.
J27 Stroke victims who suddenly lost the urge to smoke identify brain addiction region.
J22 Surprising beneficial effects of losartan on muscle in mouse models of muscular dystrophy or Marfan syndrome
J19 Nintendo Wii videogame use promotes weight loss (n=1).
J17 Strong association between low LDL levels and Parkinson disease identified in small study.
J17 Interesterified fats being used to substitute for trans-fats, but new study shows that they are unhealthy, also.
J16 DNA test to be used to determine warfarin dose.
J15 Pancreatic-polypeptide containing chewing gum - a new potential weapon against obesity
J15 New gene linked to Alzheimer disease
J09 Milk appears to eliminate the cardiovascular benefits of tea
J02 Higher serum uric acid levels associated with cognifitve impairment in the elderly.
J02 Twenty-five best dieting tips ever
J02 Moderate alcohol consumption in hypertensive men associated with lower risk of heart attack.
D27 Green vegetables may lower blood pressure via nitrates.
D20 Friendly microbes could make you fat: Bacteroides vs. Firmicutes
D13 Garlic: Good against vampires, but little protection against cardiovascular risk.
D12 Diet resulting in 10% body weight loss leads to measurable loss in bone density over 1-year period.
D12 Man eats pastrami and cheesecake, has heart attack, sues Atkins company, unsuccessfully.
D11 FDA proposes rules overhaul to expand access to experimental drugs.
D10 MRI scan used to quantify visceral fat.
N29 Procyanidins identified as cardiovascular protective agents in wines; French, Sardinian wines have the most.
N28 Folic acid, homocysteine, and cardiovascular disease: (Full text article in BMJ)
N28 Meta-analysis published in BMJ supports folate supplementation to reduce heart disease risk.
N27 Statin use in otherwise healthy people of dubious benefit.
N27 Richard Lifton honored by two medical societies for work on hypertension.
N27 Gene linked to wet form of macular degeneration.
N26 HDCN: Search index updated for audiofiles, slide/audio talks, articles, and abstracts
N16 Reanalysis of TNT study presented at AHA: Suggests high-dose atorvastatin lowers stroke, CV risk in CKD patients.
N14 Results of TROPHY prehypertension study suggesting benefit of candesartan are questioned.
N14 Fat cells stimulate the adrenal glands to secrete aldosterone: obesity - hypertension link?
N14 NEJM: No survival benefit to angioplasty done 24 hours after myocardial infarction.
N13 American Heart Association Scientific Sessions daily news: Tuesday, Nov 14
N13 American Heart Association meets in Chicago: Monday, Nov. 13 news (pdf)
N13 American Heart Association meets in Chicago: Sunday, Nov. 12 news (pdf)
N13 Pioglitazone reduces progression of atherosclerosis in diabetics
N11 Link between low systolic blood pressure and poor outcome in heart failure patients highlighted in nonuremics.
N07 Why do we eat mindlessly and what would induce us to stop?
N06 Lipoic acid may retard vascular stiffening, aging, via ceramide and phosphatases.
N06 Children's belly fat increases by more than 65% since 1990.
N02 Study shows strong link between serum uric acid levels and hypertension in African Americans
N02 Life saving pump lets heart heal
O30 UT Southwestern looking for patients with severe CHF for optimizer device study.
O25 Human tests underway on intravascular stents that dissolve.
O23 FDA approves once-a-day Coreg (carvedilol) CR for 3 cardiovascular indications
O18 Benefits of eating fish outweigh the risks
O12 Get on scale daily to keep off lost pounds.
O11 Most decaffeinated coffee contains substantial amounts of caffeine
O03 Benefits of ultralow LDL cholesterol targets (70 mg/dL) questioned.
S26 H2-blocker (famotidine) appears to have a beneficial effect in heart failure.
S18 Low blood levels previously thought to be safe linked to risk of CV death
S18 ESRD patients with implantable defibrillators at higher risk of arrhythmia.
S14 MMWR documents rising tide of obesity in the United States.
S14 Pioglitazone shows benefits in terms of cardiovascular outcomes.
S13 More bad news in JAMA paper about CV and kidney risks of COX-2 inhibitors and NSAIDS
S12 New class of pain relievers may help, not hurt, the heart
S11 Want to fight fat? Eat brown seaweed!
S07 Pre-eclampsia breakthrough hope (NEJM)
S05 Pioglitazone reduces secondary stroke risk by 50%.
S05 Carbon monoxide cytoprotective effect may explain lower risk of pre-eclampsia in smoking moms.
S05 U.S approves humanitarian use of Abiocor permanently implanted total artificial heart.
S05 Good one-year control of BP with aliskiren (Rasilez) presented at World Congress of Cardiology
A21 Red and white wine may be equally good for the heart
A18 Role of BMI as a measure of obesity and cardiovascular risk questioned.
A18 Genetic clues to cardiomyopathy and sudden death found in mice - emphasis on the right ventricle
A18 CDC: New U.S. blood lead survey data results: prevalence of elevated blood lead levels slowly improving.
A17 FDA approves use of clopidogrel for ST-segment elevating MI treated medically.
A08 Duke randomized trial favors Atkins style diet over low-fat diet.
A02 Gout increases the risk of heart attack
J31 Scripps research scientists test anti-obesity vaccine
J28 Nanotech used to concentrate angiostatin-like drugs in vascular plaques.
J25 Digitalis relatively safe treatment for diastolic heart failure.
J20 Mayo Clinic researchers discover a genetic cause of atrial fibrillation.
J15 Retinal blood vessel width may be a good indicator of coronary artery disease risk.
J29 NHLBI offers DASH diet eating guide
J28 UK NHS recommends against beta-blocker use for initial treatment of hypertension.
J22 New fat-burnng gene linked to metabolic syndrome.
J20 AHA issues new dietary recommendations; saturated and trans-fat intakes further limited
J16 CARI (Australasian) Clinical Practice Guidelines published (53 free full text review papers!)
J14 Feeding monkeys a high trans-fat diet markedly adds to abdominal fat.
J08 Benefits of potassium-enriched salt on CV mortality in elderly men
J07 Congenital malformations with first-trimester ACE-inhibitor therapy.
J05 Isis Pharma gets orphan drug status for familial hypercholesterolemia drug.
J05 International trial to see whether or not niacin can prevent heart attacks and strokes
J02 Heart attack risk with COX-2 broadened to include most NSAIDs
M30 It's the magnesium, stupid!
M24 Gum-disease bacterium can infect human arterial cells - is this the hypothesized periodontitis - CVD link?
M22 Study suggest that thiazides may have an adverse effect on CRP.
M22 Trandolapril / verapamil lowers risk of diabetes in Hispanic patients
M22 Ethanol- and smoking-induced upper digestive tract cancers linked to acetaldehyde; preventable via oral l-cysteine
M18 QTc interval and magnesium deficiency: Treatment with Mg Lactate
M17 Chocolate good? Coffee is too! Enjoy.
M15 75% of Irish taxi drivers have hypertension
M15 Moderately increased BMI in the elderly associated with reduced mortality
M15 Tacrolimus-derivative drugs protect animal brains against stroke-induced damage.
M13 Up to 40% of hypertensives in China have diabetes.
M13 FDA approves novel medication (varenicline) for smoking cessation
M11 Common (15%) gene variant affecting fatty acid breakdown increases CAD risk by 50%.
M05 Coffee consumption not associated with heart disease risk.
M03 Diuretics more effective in preventing heart failure in hypertensives when used as first-line drug.
M03 Mayo: 20 g sodium, 50% saturated fat diet improves BP, lipids in obese.
M01 Obesity rates in the U.S. underestimated by 50% due to inaccurate patient self-reporting.
M01 Common nerve cell gene plymorphism linked to QT interval changes, sudden death.
A28 Magnesium deficiency and metabolic syndrome re-emphasized
A28 Does chamomile tea interact with warfarin?
A26 FDA approves first generic pravastatin.
A25 Fatty acid binding protein aP2 gene variant associated with atherosclerosis, type 2 diabetes, in humans.
A25 Anti-oxidant selenium offers no heart disease protection in first large randomized controlled trial.
A19 An integrin-family platelet receptor found to be defective in thrombasthenia, with general implications for blood clotting.
A13 CNTF can overcome leptin resistance to fight obesity.
A08 AMBI (Tarrytown company) gets exclusive rights to Finland's PANSALT distribution in the U.S.
A08 Losartan can prevent progression of Marfan syndrome (in mice) via inhibition of TGF-beta
A04 Epicardial fat and adipocytes around coronary arteries may contribute to CAD.
A04 Lack of sleep linked to hypertension risk
M30 Manipulation of intracardiac catheters by externally applied magnetic fields to cure a. fib.
M30 Apparent CV protective effect of alcohol intake may be due to a statistical fluke.
M24 Study focuses on bread as a major cause of higher salt intake.
M24 Benefits of eating oily fish seem to be slip-sliding away.
M17 Virus blamed for obesity epidemic.
M16 Glycemic index is bupkus.
M15 Specially formulated salt substitute cuts hypertension.
M14 ACC Scientific Meeting, Atlanta: Tuesday, March 14th Newsletter (.pdf)
M14 ACC: Early treatment of pre-hypertension may postpone onset of true hypertension
M13 Diuretics, and especially, K-sparing diuretics, markedly lower risk of Alzheimer's disease.
M13 American College Cardiology Meeting: Monday, March 13th newsletter (.pdf)
M13 High dose statin therapy causes regression of coronary atherosclerosis.
M13 High-dose atorvastatin (Lipitor) improves kidney function in CKD patients in large clinical trial.
M13 Another take on B vitamins, homocysteine, and vascular risk.
M13 NEJM: B vitamins for homocysteine lowering: Fewer strokes, but more unstable angina.
M13 NEJM: Homocysteine lowering by B-vitamins of no benefit post MI - trend toward increased risk.
M13 American College of Cardiology (Atlanta) Sessions: Sunday highlights. (.pdf)
M13 American College of Cardiology (Atlanta) Sessions: Saturday highlights. (.pdf)
M13 NEJM study casts doubt on efficacy of Plavix over aspirin - and higher bleeding risk cited.
M10 Blood pressure is falling globally, and no one knows why!
M10 Major WHO study concludes calcium supplements can reduce severity but not incidence jtd of preeclampsia.
M08 Diabetes drug Byetta (exenatide) gaining attention as weight loss aid.
M07 Heavy coffee drinking plus gene variant tied to heart attack risk in Costa Ricans
M03 Serotonin may play a role in hardening of the arteries.
F28 Stress may trigger heart attacks by increasing number of blood platelets.
F22 Genetic tests developed to test for salt-sensitivity of blood pressure.
F20 Mars chocolate maker to introduce foods with flavonol-rich chocolates.
F17 Fat in liver connected to high blood pressure risk.
F12 WHO report identifies relatively high hypertension rates in males from India.
F10 IU scientists using stem cells to treat severe peripheral arterial disease.
F10 Blood levels of aldosterone linked to preservation of hearing with aging.
F07 Low fat diet benefits for women less than expected.
F05 Basic gender difference identified in coronary artery disease.
J31 AHA Scientific Statement: Dietary approaches to treat hypertension
J30 Certain adenovirus infections linked to obesity on animals and humans
J28 FDA approves first ever inhaled insulin for the treatment of diabetes.
J26 Aprotinin (Trasylol) linked to increased risk of kidney failure, heart attack and stroke.
J24 Alagebrium (a collagen cross-link breaker) softens arteries - and that's good for you.
J24 Study of Kuna indians is good news for chocoholics - procyanidin in cocoa lowers BP.
J23 Fermented milk drink reduces high blood pressure.
J23 Fetal form of toponin I, with a histidine for alanine substitution, has cardioprotective effects.
J22 AHA review casts doubt on cardiovascular health benefits of soy-based foods.
J21 British study shows that work stress linked to both heart disease and metabolic syndrome.
J19 Heart-healthy compound in chocolate identified - it's epicatechin.
J17 Aspirin protects men against myocardial infarcts and women against ischemic strokes.
J17 US FDA considering two new drugs that fight obesity.
J17 Activated blood coagulation factor VIIa under study to treat intracerebral hemorrhagic stroke.
J16 Tomato extract seems to have a large effect on lowering blood pressure.
J16 Annals: More exercise associated with 30-40% reduction in risk of dementia.
J15 Acetazolamide reduces sleep apnea severity in heart failure patients.
J15 Hypothalamus has a fatty acid sensor that may regulate food intake
J12 Caloric restriction appears to make the heart more elastic.
J10 Mid-life obesity increases mortality and cardiovascular risk.
J09 Smoker? Drink tomato juice (or drink bloody Marys) to ward off emphysema.
J04 Adenosine receptor antagonist completes phase 2 trials for congestive heart failure.
J02 UCSF study in Annals suggests that obesity increases risk of kidney failure.
J02 U.S. weighs obesity surgery options
D28 Researchers discover molecular link explaining why high-fat diet can cause type 2 diabetes.
D27 Do low birth weight babies like saltier food? Study on birth weight stirs up salt wars.
D26 Diabetes, CHF home patient monitors taking off in the UK.
D23 JAMA: Air pollution and high-fat diet combine to cause atherosclerosis in mice.
D20 Allergic reactions from drug-eluting stents
D15 Both BNP and NT-proBNP useful to deteck CHF in persons with CKD.
D07 Fructose may be cause of obesity epidemic; also raises uric acid.
D05 Heparin antibodies pose risk in heart surgery patients.
D03 Random testing shows high lead levels in some imported Chinese plums.
D03 CV benefits of lower intakes of alcohol called into question.
N29 Why trying to make couch potatoes exercise may be difficult.
N29 New AHA CPR guidelines: 30:2 compressions, cooling to 90 degrees.
N29 Fatty liver being seen increasingly in obese patients.
N28 High-carb diet linked to diabetic hypertension.
N28 Nabi's nicotine vaccine shows promise in helping smokers quit.
N24 Osteoporosis associated with six-fold increase in risk of heart disease.
N23 Sweat is a good indicator that a heart attack may be coming.
N22 Percutaneous laser myocardial revascularization no better than placebo.
N22 AHA: Late-breaking clinical trial abstracts (.pdf)
N21 Roller coaster rides can provoke arrhythmias.
N19 Researchers zero in on possible viral cause of Kawasaki disease.
N17 AHA: CV mortality benefits of diuretics linked to alpha-adducin genotype.
N16 Low-carb diet better than low-fat for improving metabolic syndrome.
N16 Collagen crosslink breaker alagebrium can soften arteries.
N16 AHA: Autologous stem cell infusions show promise in severe CAD.
N16 AHA: Aliskiren (renin inhibitor) adds to anti-HTN effects of irbesartan.
N16 Drinking decaffeinated coffee increases pro-atherosclerotic ApoB levels.
N16 Trichostatin may reduce premature atherosclerosis in lupus patients.
N16 High HDL level is pro-atherosclerotic in lupus patients.
N16 Pioglitazone reduces heart attack rate in type 2 diabetics by 28%.
N16 AHA meeting in Dallas: Wednesday newsletter.
N15 GRK5 involved in arterial restenosis lesions.
N15 AHA Meeting in Dallas: Tuesday daily newsletter (.pdf)
N15 AHA Meeting in Dallas: Monday daily newsletter (.pdf)
N13 AHA Scientific Sessions open in Dallas: Sunday daily newspaper.
N12 Risk-stratified analysis proposed to analyze RCTs to detect harm.
N12 Statins overcome learning disabilities in mice with neurofibromatosis 1.
N10 Fizzy cola consumption associated with HTN in women.
N09 No link between coffee drinking and hypertension in women.
N06 New FDA-supported website lists latest approved drug labels for all meds.
N05 Waist-hip ratio better than BMI to predict CV risk.
N01 Diabetic blacks have less coronary artery disease than diabetic whites.
O28 Botox injections effective in treating stroke spasticity.
O28 Air pollution linked to ischemic stroke risk.
O28 HDL cholesterol involved in immunity against parasites.
O27 Bone marrow stem cells may help heal hearts years after heart attack.
O27 JASN Express: Pravastatin lowers CV death risk in diabetics with CKD.
O26 ASN Renal Week 2005 abstracts now available on-line.
O25 Got high BP? Just zap your PAG - but make sure it's the front part!
O23 JAMA: Increased mortality after bariatric surgery.
O23 JAMA: Article detailing CV risk increase with Pargluva (muraglitazar)
O19 Lancet study questions efficacy of beta-blockers for hypertension.
O18 Role of prolonged bedrest to manage hypertension in pregnancy questioned.
O18 Researchers closing in on Na-K-ATPase inhibitor hormone; role in preeclampsia?
O17 Dopamine receptor gene found to play a role in blood pressure inheritance.
O16 JAMA: Cholesterol levels in U.S. inhabitants continue to drop.
O11 Fatty foods can fight inflammation, induce satiety, via CCK.
O11 Surgical menopause can trigger salt-sensitive hypertension.
O11 Microsvascular changes in the retina linked to strokes, even with normal BP.
O11 Study questions measurement of C-reactive protein to assess cardiovascular risk.
O10 RBC secretion of s-nitrosothiol regulates vascular (esp. pulmonary) tone.
O09 JASN: Glycosylated Hb in non-diabetic CKD pts. increases mortality risk.
O09 Hypertension prevalence 25% or higher in middle-aged Beijing residents.
O09 SEPS 1 gene on chromosome 15 plays key role in inflammation.
O07 Lancet: Pioglitazone lowers risk of heart attacks and strokes in diabetics.
O06 Soy compound, genistein, found to inhibit amyloid plaque formation.
O05 Generic form of amlodipine approved by the FDA
O04 Addition of amiloride to HTN drug regimens helps, esp. in African Americans.
O04 90% of Framingham cohort over 60 years of age now overweight.
S28 Toprol (metoprolol)/Topamax/Tegretrol look-alike names prompt FDA alert letter.
S28 beta-2-adrenergic receptor genetics determines survival after MI.
S26 AHA issues dietary recs for children and adolescents.
S26 Lancet study suggests wider use of statins in higher dosages may be beneficial.
S26 Smoking appears to double the risk of developing type 2 diabetes.
S26 Lead exposure plus high blood pressure may impair mental ability.
S25 Genes on chromosome 2 linked to resistant hypertension.
S23 Panic disorder may increase risk of coronary artery disease.
S22 NEJM: Efficacy of various strategies to raise HDL cholesterol.
S22 Surprisingly high cancer, heart death rates in 1-4 cig/day smokers.
S20 Novartis oral renin inhibitor aliskiren shows good results in phase III trial.
S17 Fat cells linked to production of CRP via resistin.
S13 Pioglitzaone improves cardiovascular outcomes in diabetics.
S13 Low-dose aspirin might protect against cardiac effects of COX-2 inhibitbors.
S09 MMWR: Cholesterol screening rates increasing, but only modestly.
S06 Eur Soc Cardiol 2005 Congress website
S06 CV outcomes better with amlodipine / perindopril than with atenolol / diuretic.
S06 Calcium scans can predict heart disease in healthy men.
S06 ESC 2005: Fondaparinux safer than enoxaparin, and as effective
S06 Soy protein-rich diet may help prevent fatty liver of diabetes.
S06 Folic acid, B vitamins lower homocysteine, but show no heart protective effects.
S01 JCI: New kidney hormone identified that metabolizes catecholamines.
A29 Coffee is number one source of antioxidants in U.S. diet.
A29 Prompt statin therapy after heart attack cuts mortality risk in half.
A26 Metabolic syndrome doesn't exist, diabetes groups claim.
A24 TFAH releases report on obesity in America - we're all getting fatter.
A24 The American Society of Hypertension ditches AmJH for JCH.
A22 Scios announces recommended use initiative for Natrecor.
A19 Research promising for chocolate lovers.
A19 Jury awards widow 253 million in Vioxx suit against Merck.
A19 Myogen announces phase 2 trial results of darusentan in resistant hypertension.
A17 Bluetooth scanner stroke hope.
A16 Analgesic drug use linked to high blood pressure in women.
A16 After overeating we don't compensate by eating less.
A16 PLEKHA1 gene linked to age-related macular degeneration.
A13 NEJM: Retinoid X receptors - new targets to treat metabolic syndrome.
A11 Following clinical guidelines in elderly can lead to polypharmacy.
A09 Modified form of digitalis finds role as a cancer killing drug.
A09 Salt restriction lower BP and urine protein in Blacks.
A04 Prehypertension triples heart attack risk.
J28 JASN: ADMA strongly predictive of CKD progression
J28 Propanolol may be useful in erasing traumatic memories in PTSD patients.
J25 Cocoa flavonoids: Eat two chocolate bars and call me in the morning.
J25 How estrogen via its alpha receptor may be bad for women's hearts.
J23 TGF beta receptor mutations linked to aortic dissections.
J22 NEJM: Statins had no effect on hard outcomes in diabetic ESRD patients.
J20 JASN early release: Short daily HD lowers LVH by 30%, also CRP.
J19 Annals: If Medicare were to provide ACE-I for free, it would be cost effective.
J19 Natrecor (nesiritide) safety summary (Scios)
J19 ALLHAT suggests that diuretics rule, even in Blacks with metabolic syndrome.
J19 Dark chocolate and blood pressure in the news (watch the oxalate!).
J17 Mutations in NOTCH1 gene linked to aortic valvular disease.
J17 Faulty ENPP1 gene linked to diabetes and obesity.
J15 Ruboxistaurin reduces vision loss in diabetics with macular edema.
J14 NEJM op-ed piece attacks continued use of nesiritide.
J11 Walking on cobblestones reduces blood pressure, improves balance.
J11 Hageman clotting factor linked to atherosclerosis.
J06 Therapeutic robotics offers new benefits for stroke patients.
J06 Expanding definitions of disease: economic consequences
J06 Vitamin E supps do not protect women from heart attack, stroke, or cancer
J04 Implanted stomach stimulator used as an alternative to stomach-stapling surgery.
J30 Gastric bypass surgery lowers CRP by 50%.
J30 CRP receptor in endothelial cells identified.
J30 ALLHAT subanalysis shows diuretics lower CV risk in diabetics as well as ACEI
J29 Consumer reports announces "best buy" calciuim channel blockers.
J29 Singing exercises for throat muscles target snoring, sleep apnea.
J28 Pfizer review claims no link between Viagra use and blindness.
J26 Gene hunters flock to Amish country.
J24 FDA refuses to approve broader use of Abiomed artificial heart.
J24 US FDA approves BiDil for African Americans with CHF.
J23 AHA: Public access defibrillator study doubles survivals: Policy statements.
J22 Initial FDA review of Abiomed artificial heart is mixed.
J17 FDA advisory panel recommends approval of BiDil for CHF in Blacks.
J17 High levels of ADMA associated with renal disease progression in CKD.
J17 John Laragh raises concern about MD conflicts of interest at the Am Soc HTN.
J17 Study sheds light on why diabetes drugs (thiazolidinediones) cause edema.
J16 BMJ: Should everyone over 50 be taking a daily aspirin?
J14 FDA examines application of BiDil (two vasodilators) to treat CHF in Blacks.
J14 Viagra effective in treating pulmonary arterial HTN in kids.
J13 Highlights from Am Soc Hypertens Meeting (via the ESH)
J13 Compression stockings markedly cut risk of DVT on airplane flights.
J07 Plasma BNP distinguishes restrictive myopathy from constrictive pericarditis
J07 Low vitamin B12 levels common, associated with high homocysteine levels.
J05 Gene therapy reverses pulmonary hypertension
J04 JASN Express: Crit-line blood volume monitoring fails to reduce hospitalizations
J04 CDC defends its position about obesity and increased mortality risk.
M31 Off-pump, on-pump cardiac bypass methods give comparable results.
M27 Adverse impact of second-hand smoke stronger than previously believed.
M25 Atherosclerosis linked to inefficient mitochondria in vascular endothelial cells
M24 Crestor (rosuvastatin) associated with higher adverse event risk.
M24 Higher milk intake associated with lower CV, stroke risk.
M21 Am Soc Hypertension writing group comes up with new definition of hypertension.
M20 American Society of HTN 2005 meeting abstracts
M19 Am J Nephrol: Carnitine therapy associated with decreased hospitalizations
M18 NEJM: Cystatin levels predict mortality better than Scr in the elderly..
M18 Arteriosclerosis Thrombosis Vasc Biology abstracts, 2005 (pdf)
M18 ASH: New onset diabetes 23% higher with amlodipine vs. valsartan.
M12 Animal studies suggest thyroid hormone may help failing hearts.
M12 Active vaccine prevents prion disease from developing in mice.
M10 Am Soc Hypertension focuses on Hispanic hypertension.
M10 Threefold increase in sudden cardiac death from certain non-cardiac drugs.
M09 Pioglitazone reduces carotid artery thickness in diabetics.
M07 Immune gene with 20% prevalence linked to CAD, rheumatism, and MS.
M06 Madison and Montreal researchers study genetics of HTN in French Canadians.
M06 Pegaptanib shows promising results in treating diabetic macular edema.
M05 Overexpressing catalase in mice mitochondria extends lifespan by 20%.
M03 Consumer Reports website suggest Best Buys for ACE inhibitors.
M03 Schelling paper that is the basis for the dipstick protein-SC calculator
M03 Schelling-Case Western dipstick proteinuria/specific gravity calculator.
M02 Is it raining nanobacteria and if so, is this an important health problem?
M02 FGF-21 finds itself as a new therapy for type 2 diabetes.
M02 Transcendental meditation may expand lifespan in 18 year randomized trial.
A29 ACAT2 cholesterol transforming enzyme a key player in atherosclerosis.
A28 Potassium channel gene linked to how much sleep different persons need.
A27 Combo Vytorin (ezetimibe + simvastatin) lower CHO better than atorvastatin alone
A21 Could an adenovirus be responsible for recent epidemic of obesity?
A21 My.pyramid.gov - new U.S. government website with dietary guidelines
A21 Studies in mice tie sleep disturbances to metabolic syndrome.
A20 Obesity death risk overstated; modestly obese have higher survival rate.
A20 Nesiritide associated with an increased death rate in CHF patients.
A18 Melbourne researchers develop safer and more effective "aspirin".
A17 Exercise has trivial effect, and only on DBP, in older adults.
A14 Heart ring fixes two problems at once.
A13 Heart valve ring reverses damage from congestive heart failure, easing symptoms
A11 New gene found in 20% of people may be behind CV-inflammatory syndrome.
A08 New kidney protein 'renalase' - regulates heart contraction and blood pressure
A08 Liver may be source of 'good' cholesterol
A07 Excimer laser angioplasty used to reduce renal artery stent restenosis.
A06 Table of contents for new K/DOQI cardiovascular guidelines
A06