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HDCN News Archive -- Hypertension, CV Disease
M16 Small molecule found that can disassemble amyloid proteins associated with Alzheimer's disease.
M16 New NHANES analysis finds CV mortality increased in patients following a lower salt intake.
M15 Lower-dose tissue plasminogen activator treatment improves survival in patients with hemorrhagic stroke.
M15 Biopterin derivative may be effective treatment for severe heart failure.
M13 Preop beta blockers reduce heart attack risk but markedly increase total mortality.
M13 Prism eyeglasses expand view for patients with stroke-induced hemianopia.
M12 CPR rescuers do not need to stop compression while administering defibrillator shocks.
M12 Preeclampsia-like condition develops in mice with knockout of catechol-O-methyltransferase (COMT) gene
M09 Darapladib lowers the activity of inflammatory enzyme associated with vascular plaque.
M07 S100A1 protein found in heart, blood vessels; linked to heart damage and to hypertension.
M07 Women at high risk for CV events are not benefitted by homocysteine-lowering regimen of B vitamins (JAMA).
M05 ASN Renal Week abstract archives 2003-2006 now available on-line in .pdf format.
M04 Nature genetics: More obesity genes found
M02 New ACE 2 activator compounds lower blood pressure in rats and also reduce cardiac and renal fibrosis.
M01 Obesity linked to heart failure and inflammatory mediator elevation in observational study.
A30 Scientists synthesize molecule capable of releasing hydrogen sulfide over extended periods - possible role in donor organ preservation?
A29 High blood theobromine levels (presumably from eating chocolate) may protect against pre-eclampsia.
A28 Hypertension seen in the emergency department frequently misattributed to trauma, stress, and not followed up.
A25 First ever activator of ENAC sodium channel developed.
A23 High adiponectin levels linked to kidney dysfunction and albuminuria.
A22 FDA approves compact heart assist device from Thoratec.
A21 International study of chemicals in urine links blood pressure to diet and gut bacteria.
A21 Chocolate lowers LDL cholesterol by 5% in RCT.
A17 Low serum 25D levels associated with incrased peripheral arterial disease risk.
A15 Archives Int Med: Loop diuretics associated with lower bone density in men.
A15 Nurses' Health Study shows that women who follow DASH - type diet have lower risk of heart attack.
A09 NEJM: ACEI = ARB, and ACEI + ARB no better than either ACEI or ARB, in high risk patients with diabetes or vascular disease.
A09 Two enzymes associated with acetylation linked to heart muscle contraction.
A09 New Lifton study shows that some Bartter and Gitelman mutation heterozygotes are not rare, and are protected against hypertension.
A09 JAMA RCT shows American Indian tye 2 diabetics with LDL lowered to 70 have lower carotid IMT and LV mass than those with LDL lowered to 100.
A08 Slight modification to atrial fibrillation surgery improves the results.
A08 American Heart Association issues new guidelines for treatment of resistant hypertension.
A03 Daily dose of caffeine protects rabbit brains from high serum cholesterol.
A03 New Merck heart failure drug rolofylline gives encouraging results in Phase III trial.
A02 Treating hypertension in patients more than 80 years of age reduces death rate by 20%.
A02 Adenosine receptor antagonist shows promise in heart failure.
M30 NEJM: Ezetemibe lowers LDL cholesterol when added to simvastatin, but no effects on carotid artery thickness.
M27 Pretreating animals with high-dose folate lowers infarct size.
M27 NEJM: Prognostic value of coronary artery calcium content confirmed in large study.
M25 Archives study emphasizes heritability of early-onset hypertension in men.
M16 Blood vessel protein Robo4 reverses diabetic and age-related macular degeneration in mouse model.
M15 PR, QRS, and QT intervals on ECG are increased in apparently normal elderly persons over age 80.
M13 CMS: Medicare will continue to pay for CT cardiac scans for coronary artery calcification detection.
M12 New macrophage-related protein implicated in inflammatory disease.
M10 Mutated thrombin enzyme may be useful to treat heart attacks and strokes.
M07 Angiotensin vaccine moderately effective in lowering blood pressure
M06 7th Annual Prevention in Renal Disease Conference, Toronto, Sept. 19-20, 2008.
M04 Activating PPAR-delta suppresses inflammation in vascular tissues.
M04 Retinopathy may begin at lower blood glucose levels than expected.
M04 CAPON gene linked to QT interval and heart rhythm abnormalities.
F27 African American teenagers show a high prevalence of microalbuminuria.
F27 Up to 20% of persons taking aspirin show no effect on their platelet function.
F26 Heart attack rates fall in France following institution of national smoking ban in public places.
F26 FDA: Medication guide must be given to patients with each rosiglitazone (Avandia) prescription.
F23 New techniques for detecting air bubbles in blood vessels.
F21 Study suggests that Medicare part D patients use more cardioprotective drugs after MI and live longer.
F21 Salt-rich diet linked to obesity in children via sugar-containing soft drink consumption.
F20 New study confirms increased risk of kidney failure and mortality with aprotinin.
F15 Level of airborne particulates affects microvascular function.
F13 India in the middle of a catastrophic smoking epidemic
F13 University of Groningen study (PREVEND) emphasizes utility of treating hypertension in proteinuric patients.
F13 Genomic studies suggest that CETP (cholesteryl ester transferase protein) mutants protected against coronary effects of cigarette smoking.
F12 New blood test claims to identify pre-eclampsia reliably.
F12 Nocturnal noises raise blood pressure in sleeping subjects.
F11 Declining coronary artery disease rates made a U-turn in 2000, and now are rising.
F11 Reversible, but substantial, memory problems in a subset of women taking Lipitor.
F11 Very high Ang II levels found in chorionic villi of women with pre-eclampsia.
F09 Paradigm shift: Non-osmotic, inflammation-generating accumulation of sodium in the skin
F09 Death of waitress after acute asthmatic attack on entering workplace full of cigarette smoke.
F09 Calcium channel blocker treatment for HTN associated with 23% lower risk of Parkinson's disease.
F06 More on the halted NHLBI diabetes trial arm. Role of rosiglitazone use in the intensive treatment arm unclear.
F06 Beetroot juice found to lower blood pressure because of its high nitrate content.
F05 Richard Lifton, pioneer in the genetics of hypertension, receives Wiley Prize
F01 FDA warns about depressed mood, suicidal ideation in patients taking smoking cessation drug Chantix (varenicline)
J31 Sweetened soft drinks and fruit juices linked to increased risk of gout in men.
J29 Intravascular thrombolytic therapy effective against deep vein thrombosis.
J29 Diuretics produce better outcomes than other anti-hypertensive drugs in treating metabolic syndrome.
J25 Cox-2 inhibitors can cause arrhythmias by affecting potassium channels in the heart.
J22 Aspirin resistance increases risk of heart attack or stroke.
J16 Calcium supplements raise risk of heart attacks and stroke in elderly women.
J13 Pumping rat heart created by seeding a scaffolding with baby rat myocytes.
J09 Higher cholesterol levels linked to improved muscle mass with exercise in the elderly.
J09 Cannabinoid receptor blocking drug effective in causing weight loss.
J08 Risk of cardiovascular events markedly increased when 25-D levels below 15 ng/mL.
J07 Oxygen meter molecule, PHD1 knockouts survive hypoxia - potential application to early transplant viability, heart disease
D27 Aspirin increases liver enzymes in patients taking flutamide for prostate cancer.
D26 Triglycerids and non-HDL cholesterol linked to risk of stroke.
D25 Higher levels of HDL in diabetes may inhibit NO via myristic acid binding - outcome effects unknown.
D17 Drug that stimulates thyroid hormone beta receptors effective in lowering LDL cholesterol
D14 January JASN paper reports that PROActive (pioglitazone) associated with lower CV mortality in diabetics.
D12 More heart risks identified for Avandia.
D11 Physicians unaware of guidelines to treat patients with CV risk factors and metabolic syndrome.
D04 Different anticoagulant regimens after percutaneous coronary intervention yield identical results.
D04 Waistline growth on high-carb diets linked to liver gene.
D04 Renin-angiotensin linked to obesity and insulin-resistance in a gene knockout animal model.
N27 Glucose-insulin-potassium infusion after ST-elevated MI increases risk of heart failure.
N26 MRI documents second-hand smoke injury to the lungs.
N26 Nitrosyl cobamide shows promise as an NO-donor type of drug for hypertension or heart disease.
N12 Interleukin-1 receptor blocker rilonacept effective in treating chronic gouty arthritis.
N09 Simplified anti-hypertensive drug protocol seems to be more effective than more complex approach.
N08 MMWR: CDC reviews smoking prevalence in the U.S., and the results are not good.
N08 Skeletal muscle damage due to statins may operate through atrogin-1 and thus may be preventable.
N08 New nonsteroidal natriuretic hormone identified in human urine.
N07 Perioperative beta-blocker therapy shows mixed results in large RCT.
N07 Simvastatin, but not pravastatin, associated with sleep disturbances.
N07 Prazosin appears to block some glucocorticoid effects.
N07 AHA 2007 Scientific Sessions newsletter - Nov 7th.
N06 AHA 2007 Scientific Sessions Newsletter - Nov 6th.
N06 AHA 2007 Scientific Sessions Newsletter - Nov 5th.
N06 AHA 2007 Scientific Sessions Newsletter - Nov 4th.
N05 Large VA study identifies seasonal difference in blood pressure.
N03 Metabolites of flavonoid (quercetin) present in onions found to be anti-inflammatory.
N02 U.S. AHRQ releases report claiming equal efficacy for ACE-I vs. ARB in controlling blood pressure.
N02 WNK kinases identified as key regulators of blood pressure.
O25 Bayer issues additional guidance to physicians about Trasylol (aprotinin).
O25 Genzyme launches cholesterol-binding drug (Cholestagel) in Europe for patients with primary hypercholesterolemia.
O25 Uvulopalatopharyngoplasty may help some patients with obstructive sleep apnea.
O23 Global extent of obesity epidemic in the news.
O22 Chewing gum shown to help curb appetite and reduce cravings.
O19 Sudden hearing loss associated with erectile dysfunction drugs.
O12 Is fructose really that bad?
O12 Statins help preserve lung function during aging.
O08 FDA to warn of ultrasound cardiac imaging drug risks
O03 Mini-strokes (MRI study) linked to higher uric acid levels.
S25 New, synthetic version of heparin is patented.
S21 Study links TGF-beta and cholesterol to progression of atherosclerosis.
S20 Thiazide diuretics exacerbate fructose-induced metabolic syndrome.
S20 Post-reperfusion heart damage largely prevented by hydrogen sulfide.
S12 JAMA paper shows no benefit of lowering homocysteine in CKD
S10 Protein carbamylation, reflected by homocitrulline levels, strongly associated with atherosclerosis.
S07 Low vitamin D levels during early pregnancy associated with a fivefold increase in risk of pre-eclampsia.
S06 FDA approves first generic versions of carvedilol (Coreg).
S05 New ESC-ESH hypertension treatment guidelines from ESC 2007 (webcast)
S03 European Society of Cardiology 2007 meeting: Clinical Trials Updates
A27 Obesity rates climb in most states.
A27 Patient implanted with baroreceptor stimulating devise to treat refractory hypertension.
A22 Celecoxib - may reduce stent restenosis - overall safety in heart disease still remains to be deteremined.
A22 Hypertension frequently underdiagnosed in adolescents.
A22 Lack of benefit of vitamin E on heart disease may have been due to underdosing.
A20 Mechanism of adenovirus-induced obesity clarified.
A17 FDA warning letter issued emphasizing pharmacogenomic variability in warfarin metabolism among patients.
A13 New study confirms that vitamin C, E, and beta carotene, singly or in combination, of no benefit in heart disease patients.
A10 New research shows skeleton to be an endocrine organ via osteocalcin.
A08 Annals: New study questions the increased heart attack risk with Avandia; original NEJM meta-analysis claimed to have been flawed.
A06 Trial of anti-hypertensive therapy in the very elderly, more than 80 years of age, stopped early because of positive results.
J26 Diesel fume pollution linked to arterial inflammation and atherosclerosis.
J25 Obesity spreads among friends, study concludes.
J24 Soft drinks, including diet soft drinks, linked to 50% higher risk of metabolic syndrome.
J20 Cancer risk linked to CT scan for cardiac calcification (JAMA paper) in the news.
J19 Large VA study shows 50% reduction in Alzheimer / Parkinson risk with simvastatin, but not other drugs in the same class.
J19 Weight loss pill rimonabant associated with increased suicide risk.
J13 Scleroderma Outlook Improves as Survival Increases
J12 Hydroxychloroquine (Plaquenil) may be protective against developing type 2 diabetes.
J12 Serum levels of retinol-binding programs indicate level of visceral fat.
J12 Viagra may save lives in patients with pulmonary hypertension.
J11 Modified herpes virus keeps arteries free-flowing following procedures
J09 CCJM: A different approach to resistant hypertension, emphasizing hemodynamics and the physical examination.
J05 Alteplase may have pro-inflammatory effects - mitigated by cromoglycate.
J05 High sodium in many sandwiches in the news.
J05 Dark chocolate lowers BP slightly, raises levels of nitric oxide.
J02 How stress and high-calorie intact interact to increase weight and change body fat distribution.
J29 Particulates released during renal artery angioplasty can impair kidney function.
J22 FDA clears "computerized medication box" (EMMA) for U.S. market.
J19 FDA approves ambrisentan for treatment of pulmonary artery hypertension.
J19 Hypertension vaccine against angiotensin II shows positive results.
J15 Europ Soc Hypertens releases new, updated hypertension treatment guidelines.
J13 Link between restless legs syndrome and hypertension discovered.
J11 Isradipine slows Parkinson's disease development in mice
J07 New compound similar to aMSH, causing satiety, may be effective in controlling weight in the obese.
J07 Lipid chaperone protein ap2 may be a key to type 2 diabetes and its complications.
M31 Link between mercury and vascular disease involves phospholipase D.
M25 NEJM: Full text of meta-analysis that found an increased risk of myocardial infarction with rosiglitazone.
M25 Non-caffeine components of coffee lower serum uric acid levels.
M21 FDA issues safety alert for Avandia (rosiglitazone) over possible increased heart attack risk.
M21 Statins might have a role in management of hepatitis C.
M17 MMWR publishes regional stroke incidence data for the United States (2005)
M17 Debunking the slavery hypothesis of African American hypertension
M14 Effect of polyphenols (from apples, onions, green tea) on fat catabolism.
M14 Study shows unsuspected immunomodulatory effects of glucosamine.
M07 Liver, kidney damage in people taking large amount of green tea polyphenol supplements.
M07 Centrally acting ACE inhibitors may cut dementia risk in the elderly.
M07 Inactivation of ACAT2 enzyme protects fat-eating mice from atherosclerosis.
M04 Common gene variation associated with markedly increased risk of heart attack.
M03 Nicotinamide riboside, found naturally in milk, dramatically extends lifespan in yeast via sirtuins.
M02 Study highlights gender differences in susceptibility to kidney injury.
M01 Antithrombotics (e.g., aspirin) increase hemorrhagic stroke risk in the elderly.
A30 Activating PPAR-delta may burn fat and reduce metabolic syndrome risk.
A24 AGEs and food preparation may play an important role in chronic disease.
A20 New BMJ study on adverse effects of higher salt intake in the news.
A19 Fewer heart patients need antibiotics prior to dental procedures.
A18 Animal study suggests that changing to a low-fat diet can induce stress.
A15 JAM-1 protein acts in the brain to cause hypertension.
A07 Arthritis patients with CVD who take ibuprofen plus aspirin may greatly increase their cardiac risk.
A05 Think that eating only once a day will make you lose weight? Nope.
A05 Hatfield-McCoy family feud may be linked to bad temper due to heritable pheochomocytomas.
A02 High-prevalence hemachromatosis gene linked to increased risk of stroke.
M30 NEJM: Torcetrapib markedly elevates HDL cholesterol, but shows no benefit
M27 Implanted carotid artery baroreflex stimulator lowers BP by 16-20 mm Hg.
M27 New blood thinner may work without bleeding risk
M26 Drugs work as well as stents, study finds.
M26 Tolvatptan improves signs and symptoms in patients with CHF.
M26 Nesiritide safety trial shows neutral effect on mortality in CHF patients
M26 American College of Cardiology Annual Meeting March 24-27: Monday (26) Newsletter (.pdf)
M26 American College of Cardiology Annual Meeting March 24-27: Sunday (25) Newsletter (.pdf)
M26 American College of Cardiology Annual Meeting March 24-27: Saturday (24) Newsletter (.pdf)
M21 Long-term cessation of smoking may reverse arterial stiffness.
M19 Minisub developed to explore the interior of an arterial blood vessel.
M16 Fructose linked to deranged liver metabolism in rats, involving PPARs, leptin, and metabolic syndrome.
M16 Phthalate exposure linked to metabolic syndrome
M16 Chiropractic adjustment of C1 (atlas) markedly lowers blood pressure in randomized controlled trial
M16 Increased angiotensin 1-7 levels after ACE-I treatment may inhibit lung cancer
M16 Chest compressions without mouth-to-mouth better for out-of-hospital cardiac arrest
M16 An apple a day really does keep the doctor away.
M06 FDA approves aliskiren for treatment of hypertension.
M05 Dietary copper in the news after copper supplementation helps prevent heart failure in stressed rodents.
M05 Atkins diet may be the most effective with few obvious adverse effects
F28 Nifedipine found to mobilize liver iron stores in an animal model of hemochromatosis.
F26 Garlic powerless against cholesterol.
F22 Blood pressure across countries linked to level of happiness of its inhabitants.
F21 Apolipoprotein C1 linked to obesity and type 2 diabetes in American Indians.
F19 Relationship between circadian rhythm clock and blood pressure identified.
F19 CRP liver protein induces hypertension.
F16 MMWR reports on geographic variation in prevalence of heart disease in the U.S.
F14 Neutrophil-derived peptidase enzyme found to be a key player in development of aortic aneurysms.
J30 Need a new aortic valve? No problem. We'll put one in percutaneously.
J30 One third of young people who died suddenly and inexplicably had genetic arrhythmic heart defects.
J29 Health benefits of fruits and vegetables apply to their juices as well.
J29 Major link in brain-obesity puzzle found.
J27 Stroke victims who suddenly lost the urge to smoke identify brain addiction region.
J22 Surprising beneficial effects of losartan on muscle in mouse models of muscular dystrophy or Marfan syndrome
J19 Nintendo Wii videogame use promotes weight loss (n=1).
J17 Strong association between low LDL levels and Parkinson disease identified in small study.
J17 Interesterified fats being used to substitute for trans-fats, but new study shows that they are unhealthy, also.
J16 DNA test to be used to determine warfarin dose.
J15 Pancreatic-polypeptide containing chewing gum - a new potential weapon against obesity
J15 New gene linked to Alzheimer disease
J09 Milk appears to eliminate the cardiovascular benefits of tea
J02 Higher serum uric acid levels associated with cognifitve impairment in the elderly.
J02 Twenty-five best dieting tips ever
J02 Moderate alcohol consumption in hypertensive men associated with lower risk of heart attack.
D27 Green vegetables may lower blood pressure via nitrates.
D20 Friendly microbes could make you fat: Bacteroides vs. Firmicutes
D13 Garlic: Good against vampires, but little protection against cardiovascular risk.
D12 Diet resulting in 10% body weight loss leads to measurable loss in bone density over 1-year period.
D12 Man eats pastrami and cheesecake, has heart attack, sues Atkins company, unsuccessfully.
D11 FDA proposes rules overhaul to expand access to experimental drugs.
D10 MRI scan used to quantify visceral fat.
N29 Procyanidins identified as cardiovascular protective agents in wines; French, Sardinian wines have the most.
N28 Folic acid, homocysteine, and cardiovascular disease: (Full text article in BMJ)
N28 Meta-analysis published in BMJ supports folate supplementation to reduce heart disease risk.
N27 Statin use in otherwise healthy people of dubious benefit.
N27 Richard Lifton honored by two medical societies for work on hypertension.
N27 Gene linked to wet form of macular degeneration.
N26 HDCN: Search index updated for audiofiles, slide/audio talks, articles, and abstracts
N16 Reanalysis of TNT study presented at AHA: Suggests high-dose atorvastatin lowers stroke, CV risk in CKD patients.
N14 Results of TROPHY prehypertension study suggesting benefit of candesartan are questioned.
N14 Fat cells stimulate the adrenal glands to secrete aldosterone: obesity - hypertension link?
N14 NEJM: No survival benefit to angioplasty done 24 hours after myocardial infarction.
N13 American Heart Association Scientific Sessions daily news: Tuesday, Nov 14
N13 American Heart Association meets in Chicago: Monday, Nov. 13 news (pdf)
N13 American Heart Association meets in Chicago: Sunday, Nov. 12 news (pdf)
N13 Pioglitazone reduces progression of atherosclerosis in diabetics
N11 Link between low systolic blood pressure and poor outcome in heart failure patients highlighted in nonuremics.
N07 Why do we eat mindlessly and what would induce us to stop?
N06 Lipoic acid may retard vascular stiffening, aging, via ceramide and phosphatases.
N06 Children's belly fat increases by more than 65% since 1990.
N02 Study shows strong link between serum uric acid levels and hypertension in African Americans
N02 Life saving pump lets heart heal
O30 UT Southwestern looking for patients with severe CHF for optimizer device study.
O25 Human tests underway on intravascular stents that dissolve.
O23 FDA approves once-a-day Coreg (carvedilol) CR for 3 cardiovascular indications
O18 Benefits of eating fish outweigh the risks
O12 Get on scale daily to keep off lost pounds.
O11 Most decaffeinated coffee contains substantial amounts of caffeine
O03 Benefits of ultralow LDL cholesterol targets (70 mg/dL) questioned.
S26 H2-blocker (famotidine) appears to have a beneficial effect in heart failure.
S18 Low blood levels previously thought to be safe linked to risk of CV death
S18 ESRD patients with implantable defibrillators at higher risk of arrhythmia.
S14 MMWR documents rising tide of obesity in the United States.
S14 Pioglitazone shows benefits in terms of cardiovascular outcomes.
S13 More bad news in JAMA paper about CV and kidney risks of COX-2 inhibitors and NSAIDS
S12 New class of pain relievers may help, not hurt, the heart
S11 Want to fight fat? Eat brown seaweed!
S07 Pre-eclampsia breakthrough hope (NEJM)
S05 Pioglitazone reduces secondary stroke risk by 50%.
S05 Carbon monoxide cytoprotective effect may explain lower risk of pre-eclampsia in smoking moms.
S05 U.S approves humanitarian use of Abiocor permanently implanted total artificial heart.
S05 Good one-year control of BP with aliskiren (Rasilez) presented at World Congress of Cardiology
A21 Red and white wine may be equally good for the heart
A18 Role of BMI as a measure of obesity and cardiovascular risk questioned.
A18 Genetic clues to cardiomyopathy and sudden death found in mice - emphasis on the right ventricle
A18 CDC: New U.S. blood lead survey data results: prevalence of elevated blood lead levels slowly improving.
A17 FDA approves use of clopidogrel for ST-segment elevating MI treated medically.
A08 Duke randomized trial favors Atkins style diet over low-fat diet.
A02 Gout increases the risk of heart attack
J31 Scripps research scientists test anti-obesity vaccine
J28 Nanotech used to concentrate angiostatin-like drugs in vascular plaques.
J25 Digitalis relatively safe treatment for diastolic heart failure.
J20