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HDCN News Archive -- Hypertension, CV Disease
M16	Small molecule found that can disassemble amyloid proteins associated with Alzheimer's disease.
M16	New NHANES analysis finds CV mortality increased in patients following a lower salt intake.
M15	Lower-dose tissue plasminogen activator treatment improves survival in patients with hemorrhagic stroke.
M15	Biopterin derivative may be effective treatment for severe heart failure.
M13	Preop beta blockers reduce heart attack risk but markedly increase total mortality.
M13	Prism eyeglasses expand view for patients with stroke-induced hemianopia.
M12	CPR rescuers do not need to stop compression while administering defibrillator shocks.
M12	Preeclampsia-like condition develops in mice with knockout of catechol-O-methyltransferase (COMT) gene
M09	Darapladib lowers the activity of inflammatory enzyme associated with vascular plaque.
M07	S100A1 protein found in heart, blood vessels; linked to heart damage and to hypertension.
M07	Women at high risk for CV events are not benefitted by homocysteine-lowering regimen of B vitamins (JAMA).
M05	ASN Renal Week abstract archives 2003-2006 now available on-line in .pdf format.
M04	Nature genetics: More obesity genes found
M02	New ACE 2 activator compounds lower blood pressure in rats and also reduce cardiac and renal fibrosis.
M01	Obesity linked to heart failure and inflammatory mediator elevation in observational study.
A30	Scientists synthesize molecule capable of releasing hydrogen sulfide over extended periods - possible role in donor organ preservation?
A29	High blood theobromine levels (presumably from eating chocolate) may protect against pre-eclampsia.
A28	Hypertension seen in the emergency department frequently misattributed to trauma, stress, and not followed up.
A25	First ever activator of ENAC sodium channel developed.
A23	High adiponectin levels linked to kidney dysfunction and albuminuria.
A22	FDA approves compact heart assist device from Thoratec.
A21	International study of chemicals in urine links blood pressure to diet and gut bacteria.
A21	Chocolate lowers LDL cholesterol by 5% in RCT.
A17	Low serum 25D levels associated with incrased peripheral arterial disease risk.
A15	Archives Int Med: Loop diuretics associated with lower bone density in men.
A15	Nurses' Health Study shows that women who follow DASH - type diet have lower risk of heart attack.
A09	NEJM: ACEI = ARB, and ACEI + ARB no better than either ACEI or ARB, in high risk patients with diabetes or vascular disease.
A09	Two enzymes associated with acetylation linked to heart muscle contraction.
A09	New Lifton study shows that some Bartter and Gitelman mutation heterozygotes are not rare, and are protected against hypertension.
A09	JAMA RCT shows American Indian tye 2 diabetics with LDL lowered to 70 have lower carotid IMT and LV mass than those with LDL lowered to 100.
A08	Slight modification to atrial fibrillation surgery improves the results.
A08	American Heart Association issues new guidelines for treatment of resistant hypertension.
A03	Daily dose of caffeine protects rabbit brains from high serum cholesterol.
A03	New Merck heart failure drug rolofylline gives encouraging results in Phase III trial.
A02	Treating hypertension in patients more than 80 years of age reduces death rate by 20%.
A02	Adenosine receptor antagonist shows promise in heart failure.
M30	NEJM: Ezetemibe lowers LDL cholesterol when added to simvastatin, but no effects on carotid artery thickness.
M27	Pretreating animals with high-dose folate lowers infarct size.
M27	NEJM: Prognostic value of coronary artery calcium content confirmed in large study.
M25	Archives study emphasizes heritability of early-onset hypertension in men.
M16	Blood vessel protein Robo4 reverses diabetic and age-related macular degeneration in mouse model.
M15	PR, QRS, and QT intervals on ECG are increased in apparently normal elderly persons over age 80.
M13	CMS: Medicare will continue to pay for CT cardiac scans for coronary artery calcification detection.
M12	New macrophage-related protein implicated in inflammatory disease.
M10	Mutated thrombin enzyme may be useful to treat heart attacks and strokes.
M07	Angiotensin vaccine moderately effective in lowering blood pressure
M06	7th Annual Prevention in Renal Disease Conference, Toronto, Sept. 19-20, 2008.
M04	Activating PPAR-delta suppresses inflammation in vascular tissues.
M04	Retinopathy may begin at lower blood glucose levels than expected.
M04	CAPON gene linked to QT interval and heart rhythm abnormalities.
F27	African American teenagers show a high prevalence of microalbuminuria.
F27	Up to 20% of persons taking aspirin show no effect on their platelet function.
F26	Heart attack rates fall in France following institution of national smoking ban in public places.
F26	FDA: Medication guide must be given to patients with each rosiglitazone (Avandia) prescription.
F23	New techniques for detecting air bubbles in blood vessels.
F21	Study suggests that Medicare part D patients use more cardioprotective drugs after MI and live longer.
F21	Salt-rich diet linked to obesity in children via sugar-containing soft drink consumption.
F20	New study confirms increased risk of kidney failure and mortality with aprotinin.
F15	Level of airborne particulates affects microvascular function.
F13	India in the middle of a catastrophic smoking epidemic
F13	University of Groningen study (PREVEND) emphasizes utility of treating hypertension in proteinuric patients.
F13	Genomic studies suggest that CETP (cholesteryl ester transferase protein) mutants protected against coronary effects of cigarette smoking.
F12	New blood test claims to identify pre-eclampsia reliably.
F12	Nocturnal noises raise blood pressure in sleeping subjects.
F11	Declining coronary artery disease rates made a U-turn in 2000, and now are rising.
F11	Reversible, but substantial, memory problems in a subset of women taking Lipitor.
F11	Very high Ang II levels found in chorionic villi of women with pre-eclampsia.
F09	Paradigm shift: Non-osmotic, inflammation-generating accumulation of sodium in the skin
F09	Death of waitress after acute asthmatic attack on entering workplace full of cigarette smoke.
F09	Calcium channel blocker treatment for HTN associated with 23% lower risk of Parkinson's disease.
F06	More on the halted NHLBI diabetes trial arm. Role of rosiglitazone use in the intensive treatment arm unclear.
F06	Beetroot juice found to lower blood pressure because of its high nitrate content.
F05	Richard Lifton, pioneer in the genetics of hypertension, receives Wiley Prize
F01	FDA warns about depressed mood, suicidal ideation in patients taking smoking cessation drug Chantix (varenicline)
J31	Sweetened soft drinks and fruit juices linked to increased risk of gout in men.
J29	Intravascular thrombolytic therapy effective against deep vein thrombosis.
J29	Diuretics produce better outcomes than other anti-hypertensive drugs in treating metabolic syndrome.
J25	Cox-2 inhibitors can cause arrhythmias by affecting potassium channels in the heart.
J22	Aspirin resistance increases risk of heart attack or stroke.
J16	Calcium supplements raise risk of heart attacks and stroke in elderly women.
J13	Pumping rat heart created by seeding a scaffolding with baby rat myocytes.
J09	Higher cholesterol levels linked to improved muscle mass with exercise in the elderly.
J09	Cannabinoid receptor blocking drug effective in causing weight loss.
J08	Risk of cardiovascular events markedly increased when 25-D levels below 15 ng/mL.
J07	Oxygen meter molecule, PHD1 knockouts survive hypoxia - potential application to early transplant viability, heart disease
D27	Aspirin increases liver enzymes in patients taking flutamide for prostate cancer.
D26	Triglycerids and non-HDL cholesterol linked to risk of stroke.
D25	Higher levels of HDL in diabetes may inhibit NO via myristic acid binding - outcome effects unknown.
D17	Drug that stimulates thyroid hormone beta receptors effective in lowering LDL cholesterol
D14	January JASN paper reports that PROActive (pioglitazone) associated with lower CV mortality in diabetics.
D12	More heart risks identified for Avandia.
D11	Physicians unaware of guidelines to treat patients with CV risk factors and metabolic syndrome.
D04	Different anticoagulant regimens after percutaneous coronary intervention yield identical results.
D04	Waistline growth on high-carb diets linked to liver gene.
D04	Renin-angiotensin linked to obesity and insulin-resistance in a gene knockout animal model.
N27	Glucose-insulin-potassium infusion after ST-elevated MI increases risk of heart failure.
N26	MRI documents second-hand smoke injury to the lungs.
N26	Nitrosyl cobamide shows promise as an NO-donor type of drug for hypertension or heart disease.
N12	Interleukin-1 receptor blocker rilonacept effective in treating chronic gouty arthritis.
N09	Simplified anti-hypertensive drug protocol seems to be more effective than more complex approach.
N08	MMWR: CDC reviews smoking prevalence in the U.S., and the results are not good.
N08	Skeletal muscle damage due to statins may operate through atrogin-1 and thus may be preventable.
N08	New nonsteroidal natriuretic hormone identified in human urine.
N07	Perioperative beta-blocker therapy shows mixed results in large RCT.
N07	Simvastatin, but not pravastatin, associated with sleep disturbances.
N07	Prazosin appears to block some glucocorticoid effects.
N07	AHA 2007 Scientific Sessions newsletter - Nov 7th.
N06	AHA 2007 Scientific Sessions Newsletter - Nov 6th.
N06	AHA 2007 Scientific Sessions Newsletter - Nov 5th.
N06	AHA 2007 Scientific Sessions Newsletter - Nov 4th.
N05	Large VA study identifies seasonal difference in blood pressure.
N03	Metabolites of flavonoid (quercetin) present in onions found to be anti-inflammatory.
N02	U.S. AHRQ releases report claiming equal efficacy for ACE-I vs. ARB in controlling blood pressure.
N02	WNK kinases identified as key regulators of blood pressure.
O25	Bayer issues additional guidance to physicians about Trasylol (aprotinin).
O25	Genzyme launches cholesterol-binding drug (Cholestagel) in Europe for patients with primary hypercholesterolemia.
O25	Uvulopalatopharyngoplasty may help some patients with obstructive sleep apnea.
O23	Global extent of obesity epidemic in the news.
O22	Chewing gum shown to help curb appetite and reduce cravings.
O19	Sudden hearing loss associated with erectile dysfunction drugs.
O12	Is fructose really that bad?
O12	Statins help preserve lung function during aging.
O08	FDA to warn of ultrasound cardiac imaging drug risks
O03	Mini-strokes (MRI study) linked to higher uric acid levels.
S25	New, synthetic version of heparin is patented.
S21	Study links TGF-beta and cholesterol to progression of atherosclerosis.
S20	Thiazide diuretics exacerbate fructose-induced metabolic syndrome.
S20	Post-reperfusion heart damage largely prevented by hydrogen sulfide.
S12	JAMA paper shows no benefit of lowering homocysteine in CKD
S10	Protein carbamylation, reflected by homocitrulline levels, strongly associated with atherosclerosis.
S07	Low vitamin D levels during early pregnancy associated with a fivefold increase in risk of pre-eclampsia.
S06	FDA approves first generic versions of carvedilol (Coreg).
S05	New ESC-ESH hypertension treatment guidelines from ESC 2007 (webcast)
S03	European Society of Cardiology 2007 meeting: Clinical Trials Updates
A27	Obesity rates climb in most states.
A27	Patient implanted with baroreceptor stimulating devise to treat refractory hypertension.
A22	Celecoxib - may reduce stent restenosis - overall safety in heart disease still remains to be deteremined.
A22	Hypertension frequently underdiagnosed in adolescents.
A22	Lack of benefit of vitamin E on heart disease may have been due to underdosing.
A20	Mechanism of adenovirus-induced obesity clarified.
A17	FDA warning letter issued emphasizing pharmacogenomic variability in warfarin metabolism among patients.
A13	New study confirms that vitamin C, E, and beta carotene, singly or in combination, of no benefit in heart disease patients.
A10	New research shows skeleton to be an endocrine organ via osteocalcin.
A08	Annals: New study questions the increased heart attack risk with Avandia; original NEJM meta-analysis claimed to have been flawed.
A06	Trial of anti-hypertensive therapy in the very elderly, more than 80 years of age, stopped early because of positive results.
J26	Diesel fume pollution linked to arterial inflammation and atherosclerosis.
J25	Obesity spreads among friends, study concludes.
J24	Soft drinks, including diet soft drinks, linked to 50% higher risk of metabolic syndrome.
J20	Cancer risk linked to CT scan for cardiac calcification (JAMA paper) in the news.
J19	Large VA study shows 50% reduction in Alzheimer / Parkinson risk with simvastatin, but not other drugs in the same class.
J19	Weight loss pill rimonabant associated with increased suicide risk.
J13	Scleroderma Outlook Improves as Survival Increases
J12	Hydroxychloroquine (Plaquenil) may be protective against developing type 2 diabetes.
J12	Serum levels of retinol-binding programs indicate level of visceral fat.
J12	Viagra may save lives in patients with pulmonary hypertension.
J11	Modified herpes virus keeps arteries free-flowing following procedures
J09	CCJM: A different approach to resistant hypertension, emphasizing hemodynamics and the physical examination.
J05	Alteplase may have pro-inflammatory effects - mitigated by cromoglycate.
J05	High sodium in many sandwiches in the news.
J05	Dark chocolate lowers BP slightly, raises levels of nitric oxide.
J02	How stress and high-calorie intact interact to increase weight and change body fat distribution.
J29	Particulates released during renal artery angioplasty can impair kidney function.
J22	FDA clears "computerized medication box" (EMMA) for U.S. market.
J19	FDA approves ambrisentan for treatment of pulmonary artery hypertension.
J19	Hypertension vaccine against angiotensin II shows positive results.
J15	Europ Soc Hypertens releases new, updated hypertension treatment guidelines.
J13	Link between restless legs syndrome and hypertension discovered.
J11	Isradipine slows Parkinson's disease development in mice
J07	New compound similar to aMSH, causing satiety, may be effective in controlling weight in the obese.
J07	Lipid chaperone protein ap2 may be a key to type 2 diabetes and its complications.
M31	Link between mercury and vascular disease involves phospholipase D.
M25	NEJM: Full text of meta-analysis that found an increased risk of myocardial infarction with rosiglitazone.
M25	Non-caffeine components of coffee lower serum uric acid levels.
M21	FDA issues safety alert for Avandia (rosiglitazone) over possible increased heart attack risk.
M21	Statins might have a role in management of hepatitis C.
M17	MMWR publishes regional stroke incidence data for the United States (2005)
M17	Debunking the slavery hypothesis of African American hypertension
M14	Effect of polyphenols (from apples, onions, green tea) on fat catabolism.
M14	Study shows unsuspected immunomodulatory effects of glucosamine.
M07	Liver, kidney damage in people taking large amount of green tea polyphenol supplements.
M07	Centrally acting ACE inhibitors may cut dementia risk in the elderly.
M07	Inactivation of ACAT2 enzyme protects fat-eating mice from atherosclerosis.
M04	Common gene variation associated with markedly increased risk of heart attack.
M03	Nicotinamide riboside, found naturally in milk, dramatically extends lifespan in yeast via sirtuins.
M02	Study highlights gender differences in susceptibility to kidney injury.
M01	Antithrombotics (e.g., aspirin) increase hemorrhagic stroke risk in the elderly.
A30	Activating PPAR-delta may burn fat and reduce metabolic syndrome risk.
A24	AGEs and food preparation may play an important role in chronic disease.
A20	New BMJ study on adverse effects of higher salt intake in the news.
A19	Fewer heart patients need antibiotics prior to dental procedures.
A18	Animal study suggests that changing to a low-fat diet can induce stress.
A15	JAM-1 protein acts in the brain to cause hypertension.
A07	Arthritis patients with CVD who take ibuprofen plus aspirin may greatly increase their cardiac risk.
A05	Think that eating only once a day will make you lose weight? Nope.
A05	Hatfield-McCoy family feud may be linked to bad temper due to heritable pheochomocytomas.
A02	High-prevalence hemachromatosis gene linked to increased risk of stroke.
M30	NEJM: Torcetrapib markedly elevates HDL cholesterol, but shows no benefit
M27	Implanted carotid artery baroreflex stimulator lowers BP by 16-20 mm Hg.
M27	New blood thinner may work without bleeding risk
M26	Drugs work as well as stents, study finds.
M26	Tolvatptan improves signs and symptoms in patients with CHF.
M26	Nesiritide safety trial shows neutral effect on mortality in CHF patients
M26	American College of Cardiology Annual Meeting March 24-27: Monday (26) Newsletter (.pdf)
M26	American College of Cardiology Annual Meeting March 24-27: Sunday (25) Newsletter (.pdf)
M26	American College of Cardiology Annual Meeting March 24-27: Saturday (24) Newsletter (.pdf)
M21	Long-term cessation of smoking may reverse arterial stiffness.
M19	Minisub developed to explore the interior of an arterial blood vessel.
M16	Fructose linked to deranged liver metabolism in rats, involving PPARs, leptin, and metabolic syndrome.
M16	Phthalate exposure linked to metabolic syndrome
M16	Chiropractic adjustment of C1 (atlas) markedly lowers blood pressure in randomized controlled trial
M16	Increased angiotensin 1-7 levels after ACE-I treatment may inhibit lung cancer
M16	Chest compressions without mouth-to-mouth better for out-of-hospital cardiac arrest
M16	An apple a day really does keep the doctor away.
M06	FDA approves aliskiren for treatment of hypertension.
M05	Dietary copper in the news after copper supplementation helps prevent heart failure in stressed rodents.
M05	Atkins diet may be the most effective with few obvious adverse effects
F28	Nifedipine found to mobilize liver iron stores in an animal model of hemochromatosis.
F26	Garlic powerless against cholesterol.
F22	Blood pressure across countries linked to level of happiness of its inhabitants.
F21	Apolipoprotein C1 linked to obesity and type 2 diabetes in American Indians.
F19	Relationship between circadian rhythm clock and blood pressure identified.
F19	CRP liver protein induces hypertension.
F16	MMWR reports on geographic variation in prevalence of heart disease in the U.S.
F14	Neutrophil-derived peptidase enzyme found to be a key player in development of aortic aneurysms.
J30	Need a new aortic valve? No problem. We'll put one in percutaneously.
J30	One third of young people who died suddenly and inexplicably had genetic arrhythmic heart defects.
J29	Health benefits of fruits and vegetables apply to their juices as well.
J29	Major link in brain-obesity puzzle found.
J27	Stroke victims who suddenly lost the urge to smoke identify brain addiction region.
J22	Surprising beneficial effects of losartan on muscle in mouse models of muscular dystrophy or Marfan syndrome
J19	Nintendo Wii videogame use promotes weight loss (n=1).
J17	Strong association between low LDL levels and Parkinson disease identified in small study.
J17	Interesterified fats being used to substitute for trans-fats, but new study shows that they are unhealthy, also.
J16	DNA test to be used to determine warfarin dose.
J15	Pancreatic-polypeptide containing chewing gum - a new potential weapon against obesity
J15	New gene linked to Alzheimer disease
J09	Milk appears to eliminate the cardiovascular benefits of tea
J02	Higher serum uric acid levels associated with cognifitve impairment in the elderly.
J02	Twenty-five best dieting tips ever
J02	Moderate alcohol consumption in hypertensive men associated with lower risk of heart attack.
D27	Green vegetables may lower blood pressure via nitrates.
D20	Friendly microbes could make you fat: Bacteroides vs. Firmicutes
D13	Garlic: Good against vampires, but little protection against cardiovascular risk.
D12	Diet resulting in 10% body weight loss leads to measurable loss in bone density over 1-year period.
D12	Man eats pastrami and cheesecake, has heart attack, sues Atkins company, unsuccessfully.
D11	FDA proposes rules overhaul to expand access to experimental drugs.
D10	MRI scan used to quantify visceral fat.
N29	Procyanidins identified as cardiovascular protective agents in wines; French, Sardinian wines have the most.
N28	Folic acid, homocysteine, and cardiovascular disease: (Full text article in BMJ)
N28	Meta-analysis published in BMJ supports folate supplementation to reduce heart disease risk.
N27	Statin use in otherwise healthy people of dubious benefit.
N27	Richard Lifton honored by two medical societies for work on hypertension.
N27	Gene linked to wet form of macular degeneration.
N26	HDCN: Search index updated for audiofiles, slide/audio talks, articles, and abstracts
N16	Reanalysis of TNT study presented at AHA: Suggests high-dose atorvastatin lowers stroke, CV risk in CKD patients.
N14	Results of TROPHY prehypertension study suggesting benefit of candesartan are questioned.
N14	Fat cells stimulate the adrenal glands to secrete aldosterone: obesity - hypertension link?
N14	NEJM: No survival benefit to angioplasty done 24 hours after myocardial infarction.
N13	American Heart Association Scientific Sessions daily news: Tuesday, Nov 14
N13	American Heart Association meets in Chicago: Monday, Nov. 13 news (pdf)
N13	American Heart Association meets in Chicago: Sunday, Nov. 12 news (pdf)
N13	Pioglitazone reduces progression of atherosclerosis in diabetics
N11	Link between low systolic blood pressure and poor outcome in heart failure patients highlighted in nonuremics.
N07	Why do we eat mindlessly and what would induce us to stop?
N06	Lipoic acid may retard vascular stiffening, aging, via ceramide and phosphatases.
N06	Children's belly fat increases by more than 65% since 1990.
N02	Study shows strong link between serum uric acid levels and hypertension in African Americans
N02	Life saving pump lets heart heal
O30	UT Southwestern looking for patients with severe CHF for optimizer device study.
O25	Human tests underway on intravascular stents that dissolve.
O23	FDA approves once-a-day Coreg (carvedilol) CR for 3 cardiovascular indications
O18	Benefits of eating fish outweigh the risks
O12	Get on scale daily to keep off lost pounds.
O11	Most decaffeinated coffee contains substantial amounts of caffeine
O03	Benefits of ultralow LDL cholesterol targets (70 mg/dL) questioned.
S26	H2-blocker (famotidine) appears to have a beneficial effect in heart failure.
S18	Low blood levels previously thought to be safe linked to risk of CV death
S18	ESRD patients with implantable defibrillators at higher risk of arrhythmia.
S14	MMWR documents rising tide of obesity in the United States.
S14	Pioglitazone shows benefits in terms of cardiovascular outcomes.
S13	More bad news in JAMA paper about CV and kidney risks of COX-2 inhibitors and NSAIDS
S12	New class of pain relievers may help, not hurt, the heart
S11	Want to fight fat? Eat brown seaweed!
S07	Pre-eclampsia breakthrough hope (NEJM)
S05	Pioglitazone reduces secondary stroke risk by 50%.
S05	Carbon monoxide cytoprotective effect may explain lower risk of pre-eclampsia in smoking moms.
S05	U.S approves humanitarian use of Abiocor permanently implanted total artificial heart.
S05	Good one-year control of BP with aliskiren (Rasilez) presented at World Congress of Cardiology
A21	Red and white wine may be equally good for the heart
A18	Role of BMI as a measure of obesity and cardiovascular risk questioned.
A18	Genetic clues to cardiomyopathy and sudden death found in mice - emphasis on the right ventricle
A18	CDC: New U.S. blood lead survey data results: prevalence of elevated blood lead levels slowly improving.
A17	FDA approves use of clopidogrel for ST-segment elevating MI treated medically.
A08	Duke randomized trial favors Atkins style diet over low-fat diet.
A02	Gout increases the risk of heart attack
J31	Scripps research scientists test anti-obesity vaccine
J28	Nanotech used to concentrate angiostatin-like drugs in vascular plaques.
J25	Digitalis relatively safe treatment for diastolic heart failure.
J20